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| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Nature ecology & evolution
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/39953253/ |
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| _version_ | 1868266242349989890 |
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| author | Li, Ye Hu, Mingliang Zhang, Zhigang Wu, Baosheng Zheng, Jiangmin Zhang, Fenghua Hao, Jiaqi Xue, Tingfeng Li, Zhaohong Zhu, Chenglong Liu, Yuxuan Zhao, Lei Xu, Wenjie Xin, Peidong Feng, Chenguang Wang, Wen Zhao, Yilin Qiu, Qiang Wang, Kun |
| author_facet | Li, Ye Hu, Mingliang Zhang, Zhigang Wu, Baosheng Zheng, Jiangmin Zhang, Fenghua Hao, Jiaqi Xue, Tingfeng Li, Zhaohong Zhu, Chenglong Liu, Yuxuan Zhao, Lei Xu, Wenjie Xin, Peidong Feng, Chenguang Wang, Wen Zhao, Yilin Qiu, Qiang Wang, Kun Li, Ye Hu, Mingliang Zhang, Zhigang Wu, Baosheng Zheng, Jiangmin Zhang, Fenghua Hao, Jiaqi Xue, Tingfeng Li, Zhaohong Zhu, Chenglong Liu, Yuxuan Zhao, Lei Xu, Wenjie Xin, Peidong Feng, Chenguang Wang, Wen Zhao, Yilin Qiu, Qiang Wang, Kun |
| collection | PubMed - marine biology |
| contents | Origin and stepwise evolution of vertebrate lungs. Li, Ye Hu, Mingliang Zhang, Zhigang Wu, Baosheng Zheng, Jiangmin Zhang, Fenghua Hao, Jiaqi Xue, Tingfeng Li, Zhaohong Zhu, Chenglong Liu, Yuxuan Zhao, Lei Xu, Wenjie Xin, Peidong Feng, Chenguang Wang, Wen Zhao, Yilin Qiu, Qiang Wang, Kun Animals Lung Biological Evolution Vertebrates Mice Fishes Lungs are essential respiratory organs in terrestrial vertebrates, present in most bony fishes but absent in cartilaginous fishes, making them an ideal model for studying organ evolution. Here we analysed single-cell RNA sequencing data from adult and developing lungs across vertebrate species, revealing significant similarities in cell composition, developmental trajectories and gene expression patterns. Surprisingly, a large proportion of lung-related genes, coexpression patterns and many lung enhancers are present in cartilaginous fishes despite their lack of lungs, suggesting that a substantial genetic foundation for lung development existed in the last common ancestor of jawed vertebrates. In addition, the 1,040 enhancers that emerged since the last common ancestor of bony fishes probably contain lung-specific elements that led to the development of lungs. We further identified alveolar type 1 cells as a mammal-specific alveolar cell type, along with several mammal-specific genes, including ager and sfta2, that are highly expressed in lungs. Functional validation showed that deletion of sfta2 in mice leads to severe respiratory defects, highlighting its critical role in mammalian lung features. Our study provides comprehensive insights into the evolution of vertebrate lungs, demonstrating how both regulatory network modifications and the emergence of new genes have shaped lung development and specialization across species. |
| format | Artículo científico |
| id | pubmed_39953253 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Nature ecology & evolution |
| record_format | pubmed |
| spellingShingle | Origin and stepwise evolution of vertebrate lungs. Li, Ye Hu, Mingliang Zhang, Zhigang Wu, Baosheng Zheng, Jiangmin Zhang, Fenghua Hao, Jiaqi Xue, Tingfeng Li, Zhaohong Zhu, Chenglong Liu, Yuxuan Zhao, Lei Xu, Wenjie Xin, Peidong Feng, Chenguang Wang, Wen Zhao, Yilin Qiu, Qiang Wang, Kun Animals Lung Biological Evolution Vertebrates Mice Fishes Origin and stepwise evolution of vertebrate lungs. Li, Ye Hu, Mingliang Zhang, Zhigang Wu, Baosheng Zheng, Jiangmin Zhang, Fenghua Hao, Jiaqi Xue, Tingfeng Li, Zhaohong Zhu, Chenglong Liu, Yuxuan Zhao, Lei Xu, Wenjie Xin, Peidong Feng, Chenguang Wang, Wen Zhao, Yilin Qiu, Qiang Wang, Kun Animals Lung Biological Evolution Vertebrates Mice Fishes Lungs are essential respiratory organs in terrestrial vertebrates, present in most bony fishes but absent in cartilaginous fishes, making them an ideal model for studying organ evolution. Here we analysed single-cell RNA sequencing data from adult and developing lungs across vertebrate species, revealing significant similarities in cell composition, developmental trajectories and gene expression patterns. Surprisingly, a large proportion of lung-related genes, coexpression patterns and many lung enhancers are present in cartilaginous fishes despite their lack of lungs, suggesting that a substantial genetic foundation for lung development existed in the last common ancestor of jawed vertebrates. In addition, the 1,040 enhancers that emerged since the last common ancestor of bony fishes probably contain lung-specific elements that led to the development of lungs. We further identified alveolar type 1 cells as a mammal-specific alveolar cell type, along with several mammal-specific genes, including ager and sfta2, that are highly expressed in lungs. Functional validation showed that deletion of sfta2 in mice leads to severe respiratory defects, highlighting its critical role in mammalian lung features. Our study provides comprehensive insights into the evolution of vertebrate lungs, demonstrating how both regulatory network modifications and the emergence of new genes have shaped lung development and specialization across species. |
| title | Origin and stepwise evolution of vertebrate lungs. |
| topic | Animals Lung Biological Evolution Vertebrates Mice Fishes |
| url | https://pubmed.ncbi.nlm.nih.gov/39953253/ |