Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging.
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
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BMC biology
2025
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| author | Roux, Natacha Delannoy, Clément Yu, Shin-Yi Miura, Saori Carlu, Lilian Besseau, Laurence Nakagawa, Takahiro Sato, Chihiro Kitajima, Ken Guerardel, Yann Laudet, Vincent |
| author_facet | Roux, Natacha Delannoy, Clément Yu, Shin-Yi Miura, Saori Carlu, Lilian Besseau, Laurence Nakagawa, Takahiro Sato, Chihiro Kitajima, Ken Guerardel, Yann Laudet, Vincent Roux, Natacha Delannoy, Clément Yu, Shin-Yi Miura, Saori Carlu, Lilian Besseau, Laurence Nakagawa, Takahiro Sato, Chihiro Kitajima, Ken Guerardel, Yann Laudet, Vincent |
| collection | PubMed - marine biology |
| contents | Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging. Roux, Natacha Delannoy, Clément Yu, Shin-Yi Miura, Saori Carlu, Lilian Besseau, Laurence Nakagawa, Takahiro Sato, Chihiro Kitajima, Ken Guerardel, Yann Laudet, Vincent Animals Sea Anemones N-Acetylneuraminic Acid Mucus Symbiosis Perciformes Anemonefish association with sea anemones is a prime example of mutualistic symbiosis. These fish live inside the sea anemone, benefitting from the protection of its toxic nematocysts, and in return, protect the anemone from its own predators. How anemonefish manage to avoid their host toxic stings remains unclear. One hypothesis suggests that low levels of sialic acids in anemonefish mucus prevent nematocyst discharge. This study verified four predictions: (i) anemonefish mucus has lower sialic acid levels than non-symbiotic damselfish; (ii) this reduction is specific to mucus; (iii) during development, sialic acid levels inversely correlate with protection; (iv) sea anemone mucus has minimal sialic acids. We conclude that anemonefish regulates the level of sialic acids in their mucus to avoid nematocyst discharge. We also highlight several genes implicated in sialic acid removal that could explain the protection mechanisms in place. This mechanism, potentially used by Dascyllus trimaculatus juveniles, suggests a convergent strategy for mutualistic associations with sea anemones. |
| format | Artículo científico |
| id | pubmed_39953546 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | BMC biology |
| record_format | pubmed |
| spellingShingle | Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging. Roux, Natacha Delannoy, Clément Yu, Shin-Yi Miura, Saori Carlu, Lilian Besseau, Laurence Nakagawa, Takahiro Sato, Chihiro Kitajima, Ken Guerardel, Yann Laudet, Vincent Animals Sea Anemones N-Acetylneuraminic Acid Mucus Symbiosis Perciformes Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging. Roux, Natacha Delannoy, Clément Yu, Shin-Yi Miura, Saori Carlu, Lilian Besseau, Laurence Nakagawa, Takahiro Sato, Chihiro Kitajima, Ken Guerardel, Yann Laudet, Vincent Animals Sea Anemones N-Acetylneuraminic Acid Mucus Symbiosis Perciformes Anemonefish association with sea anemones is a prime example of mutualistic symbiosis. These fish live inside the sea anemone, benefitting from the protection of its toxic nematocysts, and in return, protect the anemone from its own predators. How anemonefish manage to avoid their host toxic stings remains unclear. One hypothesis suggests that low levels of sialic acids in anemonefish mucus prevent nematocyst discharge. This study verified four predictions: (i) anemonefish mucus has lower sialic acid levels than non-symbiotic damselfish; (ii) this reduction is specific to mucus; (iii) during development, sialic acid levels inversely correlate with protection; (iv) sea anemone mucus has minimal sialic acids. We conclude that anemonefish regulates the level of sialic acids in their mucus to avoid nematocyst discharge. We also highlight several genes implicated in sialic acid removal that could explain the protection mechanisms in place. This mechanism, potentially used by Dascyllus trimaculatus juveniles, suggests a convergent strategy for mutualistic associations with sea anemones. |
| title | Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging. |
| topic | Animals Sea Anemones N-Acetylneuraminic Acid Mucus Symbiosis Perciformes |
| url | https://pubmed.ncbi.nlm.nih.gov/39953546/ |