Dynamics of infection and immunity over 50 years as marine stickleback adapt to freshwater.
Fuente:
PubMed
Enregistré dans:
| Auteurs principaux: | , , |
|---|---|
| Format: | Artículo científico |
| Langue: | en |
| Publié: |
bioRxiv : the preprint server for biology
2025
|
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1868266242321678337 |
|---|---|
| author | Sriramulu, Pranav Schluter, Dolph Bolnick, Daniel I |
| author_facet | Sriramulu, Pranav Schluter, Dolph Bolnick, Daniel I Sriramulu, Pranav Schluter, Dolph Bolnick, Daniel I |
| collection | PubMed - marine biology |
| contents | Dynamics of infection and immunity over 50 years as marine stickleback adapt to freshwater. Sriramulu, Pranav Schluter, Dolph Bolnick, Daniel I When a species colonizes a new environment, it may encounter new parasites to which its immune system is poorly adapted. After an initial spike in infection rates in the naïve founder population, the host may subsequently evolve increased immunity thereby reducing infection rates. Here, we present an example of this eco-evolutionary process, in a population of threespine stickleback () that was founded in Heisholt Quarry, a man-made quarry pond, in 1967. Marine stickleback rarely encounter tapeworms (which require freshwater to hatch), and so remain highly susceptible to infection. Initially, introduced marine fish were heavily infected by . They exhibited low levels of fibrosis, a heritable immune trait which some genotypes activate in response to infection, thereby suppressing tapeworm growth and viability. By the 1990's, the Heisholt Quarry population exhibited high rates of fibrosis, which partly suppressed infection. This increased immune response led to reduced infection rates and the tapeworm was apparently extirpated by 2021. Because fibrosis has a strong genetic basis in other stickleback populations, we infer that the newly founded stickleback-parasite interaction exhibit an eco-evolutionary process of increased immunity that effectively reduced infection. The infection and immune dynamics documented here closely match those expected from a simple eco-evo dynamic model presented here. |
| format | Artículo científico |
| id | pubmed_39975206 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | bioRxiv : the preprint server for biology |
| record_format | pubmed |
| spellingShingle | Dynamics of infection and immunity over 50 years as marine stickleback adapt to freshwater. Sriramulu, Pranav Schluter, Dolph Bolnick, Daniel I Dynamics of infection and immunity over 50 years as marine stickleback adapt to freshwater. Sriramulu, Pranav Schluter, Dolph Bolnick, Daniel I When a species colonizes a new environment, it may encounter new parasites to which its immune system is poorly adapted. After an initial spike in infection rates in the naïve founder population, the host may subsequently evolve increased immunity thereby reducing infection rates. Here, we present an example of this eco-evolutionary process, in a population of threespine stickleback () that was founded in Heisholt Quarry, a man-made quarry pond, in 1967. Marine stickleback rarely encounter tapeworms (which require freshwater to hatch), and so remain highly susceptible to infection. Initially, introduced marine fish were heavily infected by . They exhibited low levels of fibrosis, a heritable immune trait which some genotypes activate in response to infection, thereby suppressing tapeworm growth and viability. By the 1990's, the Heisholt Quarry population exhibited high rates of fibrosis, which partly suppressed infection. This increased immune response led to reduced infection rates and the tapeworm was apparently extirpated by 2021. Because fibrosis has a strong genetic basis in other stickleback populations, we infer that the newly founded stickleback-parasite interaction exhibit an eco-evolutionary process of increased immunity that effectively reduced infection. The infection and immune dynamics documented here closely match those expected from a simple eco-evo dynamic model presented here. |
| title | Dynamics of infection and immunity over 50 years as marine stickleback adapt to freshwater. |
| url | https://pubmed.ncbi.nlm.nih.gov/39975206/ |