Sex-specific reproductive impairment in Pacific oysters (Magallana gigas) exposed to TiO NPs: A focus on gonadal status.
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| Format: | Artículo científico |
| Sprache: | en |
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Marine environmental research
2025
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| author | Fernández-García, F Marques, A Jerónimo, S Oliveira, I B Carvalhais, A Pereira, V Asturiano, J F Pacheco, M Mieiro, C |
| author_facet | Fernández-García, F Marques, A Jerónimo, S Oliveira, I B Carvalhais, A Pereira, V Asturiano, J F Pacheco, M Mieiro, C Fernández-García, F Marques, A Jerónimo, S Oliveira, I B Carvalhais, A Pereira, V Asturiano, J F Pacheco, M Mieiro, C |
| collection | PubMed - marine biology |
| contents | Sex-specific reproductive impairment in Pacific oysters (Magallana gigas) exposed to TiO NPs: A focus on gonadal status. Fernández-García, F Marques, A Jerónimo, S Oliveira, I B Carvalhais, A Pereira, V Asturiano, J F Pacheco, M Mieiro, C Animals Titanium Water Pollutants, Chemical Female Male Reproduction Gonads Oxidative Stress Ostreidae Metal Nanoparticles Environmentally realistic concentrations of titanium dioxide nanoparticles (TiO NPs) are considered reprotoxic for marine bivalves. However, further investigation is needed to understand their impact on gonadal health, particularly concerning sex-specific responses. Thus, this study aimed to understand sex-based effects of TiO NPs environmentally realistic concentrations in the gonad of Pacific oysters (Magallana gigas). Oysters were exposed to 10 and 100 μg·L of TiO NPs for 3 and 7 days. Morphological parameters (condition index, sex and gametogenic stage), energy-related responses (carbohydrates, lipids, proteins, and electron transport system (ETS) activity), digestive function (alpha-amylase activity), and oxidative stress profile (antioxidants and damage) were assessed to address gonadal status. The results revealed sex-specific responses based on duration and concentration. Females reflected a drop in carbohydrate levels after 3 days at 100 μg·L, suggesting mobilization of this energy reserve to counteract TiO NP effects, followed by recovery after 7 days. Males showed reduced metabolic activity after 3 days at 10 μg·L, marked by ETS depletion, independently of oxidative stress demonstrating a compensatory response to TiO NP exposure. After 7 days, both concentrations triggered male lipid peroxidation despite carbohydrate mobilization at 10 μg·L, indicating oxidative damage in testes. These findings revealed that TiO NPs are reprotoxic for male oysters at 10 μg·L, through oxidative stress pathways, while females reflected vulnerability to 100 μg·L. This study provides valuable insights into understanding TiO NP's reprotoxicity at environmental concentrations, highlighting gonads as a target for these NPs, and their potential risks to marine bivalves. |
| format | Artículo científico |
| id | pubmed_39983464 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Marine environmental research |
| record_format | pubmed |
| spellingShingle | Sex-specific reproductive impairment in Pacific oysters (Magallana gigas) exposed to TiO NPs: A focus on gonadal status. Fernández-García, F Marques, A Jerónimo, S Oliveira, I B Carvalhais, A Pereira, V Asturiano, J F Pacheco, M Mieiro, C Animals Titanium Water Pollutants, Chemical Female Male Reproduction Gonads Oxidative Stress Ostreidae Metal Nanoparticles Sex-specific reproductive impairment in Pacific oysters (Magallana gigas) exposed to TiO NPs: A focus on gonadal status. Fernández-García, F Marques, A Jerónimo, S Oliveira, I B Carvalhais, A Pereira, V Asturiano, J F Pacheco, M Mieiro, C Animals Titanium Water Pollutants, Chemical Female Male Reproduction Gonads Oxidative Stress Ostreidae Metal Nanoparticles Environmentally realistic concentrations of titanium dioxide nanoparticles (TiO NPs) are considered reprotoxic for marine bivalves. However, further investigation is needed to understand their impact on gonadal health, particularly concerning sex-specific responses. Thus, this study aimed to understand sex-based effects of TiO NPs environmentally realistic concentrations in the gonad of Pacific oysters (Magallana gigas). Oysters were exposed to 10 and 100 μg·L of TiO NPs for 3 and 7 days. Morphological parameters (condition index, sex and gametogenic stage), energy-related responses (carbohydrates, lipids, proteins, and electron transport system (ETS) activity), digestive function (alpha-amylase activity), and oxidative stress profile (antioxidants and damage) were assessed to address gonadal status. The results revealed sex-specific responses based on duration and concentration. Females reflected a drop in carbohydrate levels after 3 days at 100 μg·L, suggesting mobilization of this energy reserve to counteract TiO NP effects, followed by recovery after 7 days. Males showed reduced metabolic activity after 3 days at 10 μg·L, marked by ETS depletion, independently of oxidative stress demonstrating a compensatory response to TiO NP exposure. After 7 days, both concentrations triggered male lipid peroxidation despite carbohydrate mobilization at 10 μg·L, indicating oxidative damage in testes. These findings revealed that TiO NPs are reprotoxic for male oysters at 10 μg·L, through oxidative stress pathways, while females reflected vulnerability to 100 μg·L. This study provides valuable insights into understanding TiO NP's reprotoxicity at environmental concentrations, highlighting gonads as a target for these NPs, and their potential risks to marine bivalves. |
| title | Sex-specific reproductive impairment in Pacific oysters (Magallana gigas) exposed to TiO NPs: A focus on gonadal status. |
| topic | Animals Titanium Water Pollutants, Chemical Female Male Reproduction Gonads Oxidative Stress Ostreidae Metal Nanoparticles |
| url | https://pubmed.ncbi.nlm.nih.gov/39983464/ |