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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of hazardous materials
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39983645/ |
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Table of Contents:
- Studying mercury and polymethyl methacrylate joint effects on endogenous hydrogen polysulfides via fluorescence imaging. Zhang, Li Zhang, Liangwei Yang, Yang Zhang, Xia Fang, Shujing Zhao, Yang Yang, Xintong Wang, Xiaoyan Chen, Lingxin Mercury Polymethyl Methacrylate Humans Fluorescent Dyes Sulfides Optical Imaging Oxidation-Reduction Heavy metal ions and micro(nano)plastic pollution have attracted increasing attention. However, their toxicological effects on endogenous reactive species at molecular level are unclear, especially their joint effects. Hence, two typical environmental poisons, mercury (Hg) and polymethyl methacrylate (PMMA), posing significant risks to both human health and ecosystems, are selected as pollution models for studying joint effects. Hydrogen polysulfides (HS, n > 1) play crucial roles in removing oxidants and intracellular electrophilic reagents, involved in regulating intracellular redox state. The understanding of its precise biological role and intricate mechanism action remains limited, especially suffering from exogenous environmental stress. Herein, we have developed a novel HS- responsive fluorescence probe P-Y with outstanding performance. Moreover, probe P-Y could image endogenous HS levels in cells, and was successfully applied for monitoring the fluctuations of endogenous HS levels to investigate their effects on redox homeostasis under Hg and PMMA single and combined exposure. This study provided imaging evidences and an absorbing insight for understanding HS function under Hg and PMMA single and joint effects in living organisms.