RNA Editing Analysis Reveals Methyl Jasmonic Acid Regulation of Fucoxanthin and Fatty Acid Metabolism in .
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| Autori principali: | , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
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Marine drugs
2025
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| _version_ | 1868266239812435969 |
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| author | Huang, Sihui Liu, Hao Xu, Ruihao Li, Wangchang Yang, Han Bao, Xinlei Hang, Yuqing Gong, Yifu Zhao, Yuxiang |
| author_facet | Huang, Sihui Liu, Hao Xu, Ruihao Li, Wangchang Yang, Han Bao, Xinlei Hang, Yuqing Gong, Yifu Zhao, Yuxiang Huang, Sihui Liu, Hao Xu, Ruihao Li, Wangchang Yang, Han Bao, Xinlei Hang, Yuqing Gong, Yifu Zhao, Yuxiang |
| collection | PubMed - marine biology |
| contents | RNA Editing Analysis Reveals Methyl Jasmonic Acid Regulation of Fucoxanthin and Fatty Acid Metabolism in . Huang, Sihui Liu, Hao Xu, Ruihao Li, Wangchang Yang, Han Bao, Xinlei Hang, Yuqing Gong, Yifu Zhao, Yuxiang Oxylipins Cyclopentanes Diatoms Xanthophylls Acetates Fatty Acids RNA Editing is a marine diatom with significant biotechnological potential, particularly in producing high-value bioactive compounds such as fucoxanthin and unsaturated fatty acids, which possess significant pharmaceutical and nutraceutical properties. However, the naturally low yields of these compounds present a major challenge for large-scale production. Methyl jasmonic acid (MeJA), a plant-derived signaling molecule, has been shown to enhance the biosynthesis of these metabolites in . While transcriptional regulation has been extensively studied, the role of post-transcriptional modifications, such as RNA editing, in mediating MeJA-induced metabolic changes remains largely unexplored. RNA editing can alter nucleotide sequences, leading to functional changes in gene expression and protein activity, thus providing a potential regulatory mechanism for enhanced biosynthesis of target metabolites. In this study, we investigated the role of RNA editing in under methyl jasmonic acid (MeJA) treatment, focusing on its impact on the accumulation of bioactive compounds such as fucoxanthin and fatty acids. We conducted a comprehensive comparative analysis of RNA editing events across MeJA-treated and control groups. Our findings reveal that MeJA treatment induces significant variations in RNA editing levels, affecting key metabolic pathways. Notably, two genes, () and , were identified as potential contributors to increased RNA editing enzyme activity and to energy metabolism and fatty acid biosynthesis under MeJA treatment. These results provide a foundation for the discovery of molecular mechanisms underlying adaptive responses in and highlight RNA editing as a critical regulatory mechanism in MeJA-induced metabolic reprogramming. |
| format | Artículo científico |
| id | pubmed_39997190 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | RNA Editing Analysis Reveals Methyl Jasmonic Acid Regulation of Fucoxanthin and Fatty Acid Metabolism in . Huang, Sihui Liu, Hao Xu, Ruihao Li, Wangchang Yang, Han Bao, Xinlei Hang, Yuqing Gong, Yifu Zhao, Yuxiang Oxylipins Cyclopentanes Diatoms Xanthophylls Acetates Fatty Acids RNA Editing RNA Editing Analysis Reveals Methyl Jasmonic Acid Regulation of Fucoxanthin and Fatty Acid Metabolism in . Huang, Sihui Liu, Hao Xu, Ruihao Li, Wangchang Yang, Han Bao, Xinlei Hang, Yuqing Gong, Yifu Zhao, Yuxiang Oxylipins Cyclopentanes Diatoms Xanthophylls Acetates Fatty Acids RNA Editing is a marine diatom with significant biotechnological potential, particularly in producing high-value bioactive compounds such as fucoxanthin and unsaturated fatty acids, which possess significant pharmaceutical and nutraceutical properties. However, the naturally low yields of these compounds present a major challenge for large-scale production. Methyl jasmonic acid (MeJA), a plant-derived signaling molecule, has been shown to enhance the biosynthesis of these metabolites in . While transcriptional regulation has been extensively studied, the role of post-transcriptional modifications, such as RNA editing, in mediating MeJA-induced metabolic changes remains largely unexplored. RNA editing can alter nucleotide sequences, leading to functional changes in gene expression and protein activity, thus providing a potential regulatory mechanism for enhanced biosynthesis of target metabolites. In this study, we investigated the role of RNA editing in under methyl jasmonic acid (MeJA) treatment, focusing on its impact on the accumulation of bioactive compounds such as fucoxanthin and fatty acids. We conducted a comprehensive comparative analysis of RNA editing events across MeJA-treated and control groups. Our findings reveal that MeJA treatment induces significant variations in RNA editing levels, affecting key metabolic pathways. Notably, two genes, () and , were identified as potential contributors to increased RNA editing enzyme activity and to energy metabolism and fatty acid biosynthesis under MeJA treatment. These results provide a foundation for the discovery of molecular mechanisms underlying adaptive responses in and highlight RNA editing as a critical regulatory mechanism in MeJA-induced metabolic reprogramming. |
| title | RNA Editing Analysis Reveals Methyl Jasmonic Acid Regulation of Fucoxanthin and Fatty Acid Metabolism in . |
| topic | Oxylipins Cyclopentanes Diatoms Xanthophylls Acetates Fatty Acids RNA Editing |
| url | https://pubmed.ncbi.nlm.nih.gov/39997190/ |