Histological and biochemical evidence of CrO and AlO nanoparticles toxicity in the marine gastropod Stramonita haemastoma: A preliminary application of integrated biomarker response (IBR).
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
2025
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| author | Sedrati, Fateh Bouzahouane, Hana Menaa, Mohcen Khaldi, Fadila Bouarroudj, Tayeb Gzara, Lassaad Bensalem, Mounira Laouar, Omar Sleimi, Noomene Nasri, Hichem Silva, Carla O Ouali, Kheireddine |
| author_facet | Sedrati, Fateh Bouzahouane, Hana Menaa, Mohcen Khaldi, Fadila Bouarroudj, Tayeb Gzara, Lassaad Bensalem, Mounira Laouar, Omar Sleimi, Noomene Nasri, Hichem Silva, Carla O Ouali, Kheireddine Sedrati, Fateh Bouzahouane, Hana Menaa, Mohcen Khaldi, Fadila Bouarroudj, Tayeb Gzara, Lassaad Bensalem, Mounira Laouar, Omar Sleimi, Noomene Nasri, Hichem Silva, Carla O Ouali, Kheireddine |
| collection | PubMed - marine biology |
| contents | Histological and biochemical evidence of CrO and AlO nanoparticles toxicity in the marine gastropod Stramonita haemastoma: A preliminary application of integrated biomarker response (IBR). Sedrati, Fateh Bouzahouane, Hana Menaa, Mohcen Khaldi, Fadila Bouarroudj, Tayeb Gzara, Lassaad Bensalem, Mounira Laouar, Omar Sleimi, Noomene Nasri, Hichem Silva, Carla O Ouali, Kheireddine Animals Biomarkers Water Pollutants, Chemical Gastropoda Aluminum Oxide Oxidative Stress Metal Nanoparticles Chromium Compounds Gills Nanoparticles Nanoparticles (NPs) have actively contributed to nanotechnologies advancement over the last years, due to the unique properties they possess compared to their pristine counterparts. Consequently, NPs found wide applications in various fields such as the medical, biomedical, chemical, agro-food industries, and cosmetology. NP's extensive uses could lead to their release into the environment, especially in the marine ecosystems, considered as NPs sink, resulting in harmful effects on organisms. Concerns regarding NPs' toxicity in aquatic organisms have emerged, however, several points remain unexplored. In the present study, the toxicity of chromium oxide (CrO = 42 nm) and aluminum oxide (AlO = 38 nm) NPs (1 mg/L, 2.5 mg/L, and 5 mg/L) in the gills of the marine gastropod Stramonita haemastoma was assessed through time (7, 14, and 28 days) by a multi-biomarker, Integrated biomarkers response (IBR), and Histological analysis. Both NPs induced varied changes in the antioxidant system, suggesting the onset of oxidative stress marked by superoxide dismutase (SOD), catalase (CAT), acetylcholinesterase (AChE), metallothionein (MT), and malondialdehyde (MDA) levels imbalance. Varied histological alterations in the gills of S. haemastoma were also observed including inflammation, hypertrophy, and lamellar fusion, IBR proved to be a promising tool for assessing NPs toxicity in gastropods. In this study results indicated the co-response of reduced glutathione (GSH), glutathione S-transferase (GST), glutathione peroxidase (GPx), CAT, SOD, and MT after 28 days of exposure. S. haemastoma showed sensitivity to all exposure concentrations of NPs thus validating this species as a suitable indicator of NPs contamination and toxicity. |
| format | Artículo científico |
| id | pubmed_40010532 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP |
| record_format | pubmed |
| spellingShingle | Histological and biochemical evidence of CrO and AlO nanoparticles toxicity in the marine gastropod Stramonita haemastoma: A preliminary application of integrated biomarker response (IBR). Sedrati, Fateh Bouzahouane, Hana Menaa, Mohcen Khaldi, Fadila Bouarroudj, Tayeb Gzara, Lassaad Bensalem, Mounira Laouar, Omar Sleimi, Noomene Nasri, Hichem Silva, Carla O Ouali, Kheireddine Animals Biomarkers Water Pollutants, Chemical Gastropoda Aluminum Oxide Oxidative Stress Metal Nanoparticles Chromium Compounds Gills Nanoparticles Histological and biochemical evidence of CrO and AlO nanoparticles toxicity in the marine gastropod Stramonita haemastoma: A preliminary application of integrated biomarker response (IBR). Sedrati, Fateh Bouzahouane, Hana Menaa, Mohcen Khaldi, Fadila Bouarroudj, Tayeb Gzara, Lassaad Bensalem, Mounira Laouar, Omar Sleimi, Noomene Nasri, Hichem Silva, Carla O Ouali, Kheireddine Animals Biomarkers Water Pollutants, Chemical Gastropoda Aluminum Oxide Oxidative Stress Metal Nanoparticles Chromium Compounds Gills Nanoparticles Nanoparticles (NPs) have actively contributed to nanotechnologies advancement over the last years, due to the unique properties they possess compared to their pristine counterparts. Consequently, NPs found wide applications in various fields such as the medical, biomedical, chemical, agro-food industries, and cosmetology. NP's extensive uses could lead to their release into the environment, especially in the marine ecosystems, considered as NPs sink, resulting in harmful effects on organisms. Concerns regarding NPs' toxicity in aquatic organisms have emerged, however, several points remain unexplored. In the present study, the toxicity of chromium oxide (CrO = 42 nm) and aluminum oxide (AlO = 38 nm) NPs (1 mg/L, 2.5 mg/L, and 5 mg/L) in the gills of the marine gastropod Stramonita haemastoma was assessed through time (7, 14, and 28 days) by a multi-biomarker, Integrated biomarkers response (IBR), and Histological analysis. Both NPs induced varied changes in the antioxidant system, suggesting the onset of oxidative stress marked by superoxide dismutase (SOD), catalase (CAT), acetylcholinesterase (AChE), metallothionein (MT), and malondialdehyde (MDA) levels imbalance. Varied histological alterations in the gills of S. haemastoma were also observed including inflammation, hypertrophy, and lamellar fusion, IBR proved to be a promising tool for assessing NPs toxicity in gastropods. In this study results indicated the co-response of reduced glutathione (GSH), glutathione S-transferase (GST), glutathione peroxidase (GPx), CAT, SOD, and MT after 28 days of exposure. S. haemastoma showed sensitivity to all exposure concentrations of NPs thus validating this species as a suitable indicator of NPs contamination and toxicity. |
| title | Histological and biochemical evidence of CrO and AlO nanoparticles toxicity in the marine gastropod Stramonita haemastoma: A preliminary application of integrated biomarker response (IBR). |
| topic | Animals Biomarkers Water Pollutants, Chemical Gastropoda Aluminum Oxide Oxidative Stress Metal Nanoparticles Chromium Compounds Gills Nanoparticles |
| url | https://pubmed.ncbi.nlm.nih.gov/40010532/ |