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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
BMC microbiology
2025
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/40021993/ |
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| _version_ | 1868266237312630785 |
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| author | Ding, Huiyu Shi, Keming Hsiao, Min Li, Wenqing Liu, Xin Xu, Jie Yang, Yunlan Zhang, Rui |
| author_facet | Ding, Huiyu Shi, Keming Hsiao, Min Li, Wenqing Liu, Xin Xu, Jie Yang, Yunlan Zhang, Rui Ding, Huiyu Shi, Keming Hsiao, Min Li, Wenqing Liu, Xin Xu, Jie Yang, Yunlan Zhang, Rui |
| collection | PubMed - marine biology |
| contents | Two virulent Vibrio campbellii phages with potential for phage therapy in aquaculture. Ding, Huiyu Shi, Keming Hsiao, Min Li, Wenqing Liu, Xin Xu, Jie Yang, Yunlan Zhang, Rui Vibrio Aquaculture Phage Therapy Bacteriophages Vibrio Infections Animals Virulence Host Specificity Genome, Viral Podoviridae Fish Diseases As aquaculture continues to expand globally, diseases caused by Vibrio species are becoming increasingly prevalent. Vibriosis encompasses a range of infections, which can lead to symptoms such as skin lesions, hemorrhaging, and high mortality rates in fish and shellfish, especially in high-density farming systems, resulting in significant economic losses. Simultaneously, the extensive use of antibiotics has fostered the emergence of antibiotic-resistant bacteria, exacerbated disease outbreaks, and complicated control measures. Phage therapy, which leverages bacteriophages as natural antibacterial agents, offers a promising eco-friendly alternative to the antibiotics used in aquaculture. This study aimed to evaluate the potential of two vibriophages for phage therapy in aquaculture. Two virulent vibriophages, vB_VcaP_R24D and vB_VcaP_R25D, were isolated from aquaculture wastewater from seafood markets using Vibrio campbellii LMG 11216 as the host strain. The two vibriophages were identified based on their morphology, infection dynamics, host range, genomic features, lytic activity, and environmental stability. Both phages belong to the podovirus morphotype and exhibit a lytic life cycle characterised by a short latent period ( These biological and genomic characteristics highlight the potential of vB_VcaP_R24D and vB_VcaP_R25D as effective biocontrol agents for mitigating vibriosis in aquaculture. Although this study demonstrates their narrow host range, the possibility of phage infection in other untested hosts cannot be entirely excluded. Furthermore, the findings offer valuable insights for future research on phage-host interactions and the development of phage cocktails to improve disease management in aquaculture systems. |
| format | Artículo científico |
| id | pubmed_40021993 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | BMC microbiology |
| record_format | pubmed |
| spellingShingle | Two virulent Vibrio campbellii phages with potential for phage therapy in aquaculture. Ding, Huiyu Shi, Keming Hsiao, Min Li, Wenqing Liu, Xin Xu, Jie Yang, Yunlan Zhang, Rui Vibrio Aquaculture Phage Therapy Bacteriophages Vibrio Infections Animals Virulence Host Specificity Genome, Viral Podoviridae Fish Diseases Two virulent Vibrio campbellii phages with potential for phage therapy in aquaculture. Ding, Huiyu Shi, Keming Hsiao, Min Li, Wenqing Liu, Xin Xu, Jie Yang, Yunlan Zhang, Rui Vibrio Aquaculture Phage Therapy Bacteriophages Vibrio Infections Animals Virulence Host Specificity Genome, Viral Podoviridae Fish Diseases As aquaculture continues to expand globally, diseases caused by Vibrio species are becoming increasingly prevalent. Vibriosis encompasses a range of infections, which can lead to symptoms such as skin lesions, hemorrhaging, and high mortality rates in fish and shellfish, especially in high-density farming systems, resulting in significant economic losses. Simultaneously, the extensive use of antibiotics has fostered the emergence of antibiotic-resistant bacteria, exacerbated disease outbreaks, and complicated control measures. Phage therapy, which leverages bacteriophages as natural antibacterial agents, offers a promising eco-friendly alternative to the antibiotics used in aquaculture. This study aimed to evaluate the potential of two vibriophages for phage therapy in aquaculture. Two virulent vibriophages, vB_VcaP_R24D and vB_VcaP_R25D, were isolated from aquaculture wastewater from seafood markets using Vibrio campbellii LMG 11216 as the host strain. The two vibriophages were identified based on their morphology, infection dynamics, host range, genomic features, lytic activity, and environmental stability. Both phages belong to the podovirus morphotype and exhibit a lytic life cycle characterised by a short latent period ( These biological and genomic characteristics highlight the potential of vB_VcaP_R24D and vB_VcaP_R25D as effective biocontrol agents for mitigating vibriosis in aquaculture. Although this study demonstrates their narrow host range, the possibility of phage infection in other untested hosts cannot be entirely excluded. Furthermore, the findings offer valuable insights for future research on phage-host interactions and the development of phage cocktails to improve disease management in aquaculture systems. |
| title | Two virulent Vibrio campbellii phages with potential for phage therapy in aquaculture. |
| topic | Vibrio Aquaculture Phage Therapy Bacteriophages Vibrio Infections Animals Virulence Host Specificity Genome, Viral Podoviridae Fish Diseases |
| url | https://pubmed.ncbi.nlm.nih.gov/40021993/ |