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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
ACS applied materials & interfaces
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40025822/ |
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| _version_ | 1868266237308436480 |
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| author | Hu, Le Liu, Qing Wang, Yuxin Wang, Chunxiao Fan, Yinuo Liu, Shuying Shi, Yujiao Jin, Kang Tan, Wei-Qiang Pan, Panpan Chen, Jingdi |
| author_facet | Hu, Le Liu, Qing Wang, Yuxin Wang, Chunxiao Fan, Yinuo Liu, Shuying Shi, Yujiao Jin, Kang Tan, Wei-Qiang Pan, Panpan Chen, Jingdi Hu, Le Liu, Qing Wang, Yuxin Wang, Chunxiao Fan, Yinuo Liu, Shuying Shi, Yujiao Jin, Kang Tan, Wei-Qiang Pan, Panpan Chen, Jingdi |
| collection | PubMed - marine biology |
| contents | A Semi-Interpenetrating Network Hydrogel with Excellent Photothermal Antibacterial and ROS Scavenging Activities for MRSA-Infected Wounds. Hu, Le Liu, Qing Wang, Yuxin Wang, Chunxiao Fan, Yinuo Liu, Shuying Shi, Yujiao Jin, Kang Tan, Wei-Qiang Pan, Panpan Chen, Jingdi Hydrogels Methicillin-Resistant Staphylococcus aureus Animals Anti-Bacterial Agents Rats Rats, Sprague-Dawley Reactive Oxygen Species Wound Healing Staphylococcal Infections Dopamine Wound Infection Polysaccharides, Bacterial Free Radical Scavengers Nanoparticles Male Microbial Sensitivity Tests Ferrocyanides The prolonged infection of bacteria at the wound site may lead to serious physical problems. Herein, a multifunctional macroporous hydrogel with superior photothermal antibacterial and ROS scavenging activity (denoted as M-XG gel) was designed for the treatment of MRSA-infected wounds. The M-XG gels are composed of embedding Prussian blue nanoparticles (PBNPs) as photothermal converters and chelating ferric ions with xanthan gum (XG) and dopamine (DA) to form a semipermeable network. The introduction of DA occupies the cross-link sites of ferric ions, further increasing the pore size (200-500 μm open macropores) and endowing the hydrogel with ideal adhesion. The increase of cross-link sites in PBNPs formed a promising equilibrium M-XG gel with identical macroporous structures and toughened mechanical performance. The metal ligands between ferric ions and catechols, as well as the unique photothermal response of PBNPs, endow the hydrogels with a fast and stable near-infrared (NIR) photothermal conversion efficiency (48%). In the MRSA-infected SD rat trauma model, wounds treated with the M-XG gel group had completely closed after 14 days, effectively controlling wound bacterial infection and accelerating angiogenesis and collagen deposition, synergistically promoting infected wound healing. Therefore, the photothermal hydrogel with a semi-interpenetrating network demonstrates its great potential for infected wound tissue engineering. |
| format | Artículo científico |
| id | pubmed_40025822 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | ACS applied materials & interfaces |
| record_format | pubmed |
| spellingShingle | A Semi-Interpenetrating Network Hydrogel with Excellent Photothermal Antibacterial and ROS Scavenging Activities for MRSA-Infected Wounds. Hu, Le Liu, Qing Wang, Yuxin Wang, Chunxiao Fan, Yinuo Liu, Shuying Shi, Yujiao Jin, Kang Tan, Wei-Qiang Pan, Panpan Chen, Jingdi Hydrogels Methicillin-Resistant Staphylococcus aureus Animals Anti-Bacterial Agents Rats Rats, Sprague-Dawley Reactive Oxygen Species Wound Healing Staphylococcal Infections Dopamine Wound Infection Polysaccharides, Bacterial Free Radical Scavengers Nanoparticles Male Microbial Sensitivity Tests Ferrocyanides A Semi-Interpenetrating Network Hydrogel with Excellent Photothermal Antibacterial and ROS Scavenging Activities for MRSA-Infected Wounds. Hu, Le Liu, Qing Wang, Yuxin Wang, Chunxiao Fan, Yinuo Liu, Shuying Shi, Yujiao Jin, Kang Tan, Wei-Qiang Pan, Panpan Chen, Jingdi Hydrogels Methicillin-Resistant Staphylococcus aureus Animals Anti-Bacterial Agents Rats Rats, Sprague-Dawley Reactive Oxygen Species Wound Healing Staphylococcal Infections Dopamine Wound Infection Polysaccharides, Bacterial Free Radical Scavengers Nanoparticles Male Microbial Sensitivity Tests Ferrocyanides The prolonged infection of bacteria at the wound site may lead to serious physical problems. Herein, a multifunctional macroporous hydrogel with superior photothermal antibacterial and ROS scavenging activity (denoted as M-XG gel) was designed for the treatment of MRSA-infected wounds. The M-XG gels are composed of embedding Prussian blue nanoparticles (PBNPs) as photothermal converters and chelating ferric ions with xanthan gum (XG) and dopamine (DA) to form a semipermeable network. The introduction of DA occupies the cross-link sites of ferric ions, further increasing the pore size (200-500 μm open macropores) and endowing the hydrogel with ideal adhesion. The increase of cross-link sites in PBNPs formed a promising equilibrium M-XG gel with identical macroporous structures and toughened mechanical performance. The metal ligands between ferric ions and catechols, as well as the unique photothermal response of PBNPs, endow the hydrogels with a fast and stable near-infrared (NIR) photothermal conversion efficiency (48%). In the MRSA-infected SD rat trauma model, wounds treated with the M-XG gel group had completely closed after 14 days, effectively controlling wound bacterial infection and accelerating angiogenesis and collagen deposition, synergistically promoting infected wound healing. Therefore, the photothermal hydrogel with a semi-interpenetrating network demonstrates its great potential for infected wound tissue engineering. |
| title | A Semi-Interpenetrating Network Hydrogel with Excellent Photothermal Antibacterial and ROS Scavenging Activities for MRSA-Infected Wounds. |
| topic | Hydrogels Methicillin-Resistant Staphylococcus aureus Animals Anti-Bacterial Agents Rats Rats, Sprague-Dawley Reactive Oxygen Species Wound Healing Staphylococcal Infections Dopamine Wound Infection Polysaccharides, Bacterial Free Radical Scavengers Nanoparticles Male Microbial Sensitivity Tests Ferrocyanides |
| url | https://pubmed.ncbi.nlm.nih.gov/40025822/ |