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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40030089/ |
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| _version_ | 1868266234594721793 |
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| author | Zhang, Guo Dong Yang, Zhi Wei Yin, Fang Zhou Yan, Zhang Yuan Xiong, Zi Jun Ma, Shuai Guo, Zhi Kai Jiao, Rui Hua |
| author_facet | Zhang, Guo Dong Yang, Zhi Wei Yin, Fang Zhou Yan, Zhang Yuan Xiong, Zi Jun Ma, Shuai Guo, Zhi Kai Jiao, Rui Hua Zhang, Guo Dong Yang, Zhi Wei Yin, Fang Zhou Yan, Zhang Yuan Xiong, Zi Jun Ma, Shuai Guo, Zhi Kai Jiao, Rui Hua |
| collection | PubMed - marine biology |
| contents | LC-MS Guided Discovery and Biosynthetic Pathway of Coprisamides E-H, Cinnamic Acid-Containing Metabolites from the Marine Algae-Derived NAK03196. Zhang, Guo Dong Yang, Zhi Wei Yin, Fang Zhou Yan, Zhang Yuan Xiong, Zi Jun Ma, Shuai Guo, Zhi Kai Jiao, Rui Hua Streptomyces Staphylococcus aureus Molecular Structure Anti-Bacterial Agents Marine Biology Cinnamates Microbial Sensitivity Tests Chromatography, Liquid Nuclear Magnetic Resonance, Biomolecular Biosynthetic Pathways Multigene Family Liquid Chromatography-Mass Spectrometry Four cinnamoyl-containing nonribosomal peptides (CCNPs), coprisamides EH (-), were isolated from the marine algae-associated actinomycete strain NAK03196. Their structures were elucidated to be unreported coprisamides by comprehensive analyses of HRESIMS, 1D and 2D NMR spectroscopic data, Marfey's method, and MS/MS analysis. Coprisamides E () and F () bear a characteristic nonproteinogenic amino acid, 2,3-diaminopropanoic acid. The biosynthetic pathways for these isolates were proposed through a comparison of their biosynthetic gene clusters with reported homologous gene clusters. Coprisamide E () exhibited weak antibacterial activity against the Gram-positive strain . |
| format | Artículo científico |
| id | pubmed_40030089 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | LC-MS Guided Discovery and Biosynthetic Pathway of Coprisamides E-H, Cinnamic Acid-Containing Metabolites from the Marine Algae-Derived NAK03196. Zhang, Guo Dong Yang, Zhi Wei Yin, Fang Zhou Yan, Zhang Yuan Xiong, Zi Jun Ma, Shuai Guo, Zhi Kai Jiao, Rui Hua Streptomyces Staphylococcus aureus Molecular Structure Anti-Bacterial Agents Marine Biology Cinnamates Microbial Sensitivity Tests Chromatography, Liquid Nuclear Magnetic Resonance, Biomolecular Biosynthetic Pathways Multigene Family Liquid Chromatography-Mass Spectrometry LC-MS Guided Discovery and Biosynthetic Pathway of Coprisamides E-H, Cinnamic Acid-Containing Metabolites from the Marine Algae-Derived NAK03196. Zhang, Guo Dong Yang, Zhi Wei Yin, Fang Zhou Yan, Zhang Yuan Xiong, Zi Jun Ma, Shuai Guo, Zhi Kai Jiao, Rui Hua Streptomyces Staphylococcus aureus Molecular Structure Anti-Bacterial Agents Marine Biology Cinnamates Microbial Sensitivity Tests Chromatography, Liquid Nuclear Magnetic Resonance, Biomolecular Biosynthetic Pathways Multigene Family Liquid Chromatography-Mass Spectrometry Four cinnamoyl-containing nonribosomal peptides (CCNPs), coprisamides EH (-), were isolated from the marine algae-associated actinomycete strain NAK03196. Their structures were elucidated to be unreported coprisamides by comprehensive analyses of HRESIMS, 1D and 2D NMR spectroscopic data, Marfey's method, and MS/MS analysis. Coprisamides E () and F () bear a characteristic nonproteinogenic amino acid, 2,3-diaminopropanoic acid. The biosynthetic pathways for these isolates were proposed through a comparison of their biosynthetic gene clusters with reported homologous gene clusters. Coprisamide E () exhibited weak antibacterial activity against the Gram-positive strain . |
| title | LC-MS Guided Discovery and Biosynthetic Pathway of Coprisamides E-H, Cinnamic Acid-Containing Metabolites from the Marine Algae-Derived NAK03196. |
| topic | Streptomyces Staphylococcus aureus Molecular Structure Anti-Bacterial Agents Marine Biology Cinnamates Microbial Sensitivity Tests Chromatography, Liquid Nuclear Magnetic Resonance, Biomolecular Biosynthetic Pathways Multigene Family Liquid Chromatography-Mass Spectrometry |
| url | https://pubmed.ncbi.nlm.nih.gov/40030089/ |