Cover Image

PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer.

Fuente: PubMed

Saved in:

Bibliographic Details
Main Authors:	Fan, Yizeng, Wang, Yuzhao, Dan, Weichao, Zhang, Yilei, Nie, Li, Ma, Zhiqiang, Zhuang, Yanxin, Liu, Bo, Li, Mengxing, Liu, Tianjie, Wang, Zixi, Ye, Leihong, Wei, Yi, Lei, Yuzeshi, Guo, Chendong, An, Jiale, Wang, Chi, Zhang, Yulin, Zeng, Jin, Wei, Wenyi, Gan, Boyi, Li, Lei
Format:	Artículo científico
Language:	en
Published:	Nature cell biology 2025
Subjects:	Ferroptosis Protein-Arginine N-Methyltransferases Humans Animals Phospholipid Hydroperoxide Glutathione Peroxidase Methylation Arginine Mice Neoplasms F-Box-WD Repeat-Containing Protein 7 Cell Line, Tumor Female Ubiquitination Mice, Nude Mice, Inbred BALB C HEK293 Cells
Online Access:	Acceder al recurso
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.
by: Huang, Zhengyun, et al.
Published: (2026)

Secreted Apoe rewires melanoma cell state vulnerability to ferroptosis.
by: More, Sanket, et al.
Published: (2024)

Cereblon upregulation overcomes thalidomide resistance in multiple myeloma through mitochondrial functional reprogramming.
by: Marquez, Jubert, et al.
Published: (2026)

Targeted GPX4 Degradation Mediated by Hypoxia-Overcoming Nano-PDTACs for Synergistic Ferroptosis-Immunotherapy.
by: Ji, Rui, et al.
Published: (2026)

PSPC1 knockout promotes radiosensitivity, inhibits EMT, and metastasis of nasopharyngeal carcinoma cells.
by: He, Huocong, et al.
Published: (2025)

NQO1-Activatable Circular Antisense Oligonucleotides for Tumor-Cell-Specific Survivin Gene Silencing and Antitumor Therapy.
by: Zhao, Xiaoran, et al.
Published: (2025)

Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy.
by: Qiao, Ziwen, et al.
Published: (2025)

ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin-mediated degradation and facilitate viral replication.
by: Ren, Yingying, et al.
Published: (2024)

Designing a Hypoallergenic Mutant of Cra a 2 with T-Cell Reactivity.
by: Huan, Fei, et al.
Published: (2026)

MYLIP attenuates hypoxia tolerance by inducing K27-linked polyubiquitination and subsequent proteasomal degradation of HIF-α.
by: Li, Jun, et al.
Published: (2025)

Reduced myogenic differentiation capacity of satellite cell-derived myoblasts in male ICR mice compared with male C57BL/6 and BALB/c mice.
by: Suzuki, Takahiro, et al.
Published: (2026)

Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity.
by: Wang, Zixuan, et al.
Published: (2025)

The Inhibitory Effect and Mechanism of the Histidine-Rich Peptide rAj-HRP from on Human Colon Cancer HCT116 Cells.
by: Zhang, Yuebin, et al.
Published: (2024)

A T-Cell Epitope Tandem Peptide Designed from Two Major Allergens of Shows Potential for Inducing Dual Immune Tolerance.
by: Gu, Yi, et al.
Published: (2026)

Blocking RAN translation without altering repeat RNAs rescues -related ALS and FTD phenotypes.
by: Jiang, Xin, et al.
Published: (2026)

Epac (RAPGEF3) promotes betaglycan expression to mediate ciprofloxacin-induced suppression of cancer cell migration and metastasis: Mechanistic insights and drug repurposing potential.
by: Liu, Hui-Pu, et al.
Published: (2025)

KHSRP protects colorectal cancer cells against ferroptosis by regulating GPX4 expression through interaction with hnRNPM.
by: Ding, Xia, et al.
Published: (2025)

Mouse Brain Lymphatic Vessels.
by: Tamadon, Amin, et al.
Published: (2025)

Grouped immunogens are hierarchically recognized by host to generate antibodies.
by: Liu, Xiang, et al.
Published: (2026)

E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat.
by: Yu, Jian, et al.
Published: (2025)

Non-allergenic mixed T cell epitope peptides for preventing Scy p 9 allergic reactions.
by: He, Xinrong, et al.
Published: (2025)

Lamprey rescues the block of thymic epithelial cell development in the mouse -deficient thymic rudiment.
by: Morimoto, Ryo, et al.
Published: (2025)

The GPX1-OSBPL8 axis: integrating ER ferroptosis and apoptotic signaling.
by: Chang, Renin, et al.
Published: (2026)

Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer.
by: Fang, Zhangyun, et al.
Published: (2026)

Human OCEL1 senses bacterial infection to unlock inflammatory responses.
by: Li, Zhi, et al.
Published: (2025)

Activation of the γ-secretase/NICD-PXR/Notch pathway induces Taxol resistance in triple-negative breast cancer.
by: Wang, Zuo-Jun, et al.
Published: (2024)

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.
by: Cao, Yin, et al.
Published: (2025)

Synergistic induction of immunogenic cell death and tumor microenvironment remodeling by biotinylated marine polysaccharide nanoparticles for enhanced colorectal cancer therapy.
by: Wang, Hui, et al.
Published: (2026)

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C.
by: Han, Shanhao, et al.
Published: (2026)

Preliminary Insights Into the Combined Antitumor Efficacy of Onco-VV-TT and Natural Killer Cells in Glioblastoma.
by: Mirbahari, Seyedeh Nasim, et al.
Published: (2026)

Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning.
by: Pang, Yue, et al.
Published: (2025)

Functional characterization of MMAR_1296 in Mycobacterium marinum and its potential as a vaccine candidate.
by: Xie, Weile, et al.
Published: (2025)

Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury.
by: Zhan, Shuai, et al.
Published: (2025)

Inhibition of Na,K -ATPase enzyme by tetrodotoxin extract in the breast tumor xenograft Balb/c nu mouse model.
by: Ahrari, Ameneh, et al.
Published: (2025)

ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition.
by: He, Jianfeng, et al.
Published: (2025)

LECT2 promotes liver regeneration across developmental stages by activating the ADAM10-NOTCH signaling pathway.
by: Zhang, Hui, et al.
Published: (2025)

The peptide from C- Phycocyanin alleviates myocardial ischemia-reperfusion injury by suppressing ferroptosis via upregulating UCHL3.
by: Li, Zhaoqing, et al.
Published: (2025)

Dpcd Induces Hydrocephalus Because of Partial Defects in the Inner Dynein Arms, With Abnormal Ciliary Motility.
by: Yamamoto, Taiki, et al.
Published: (2026)

Phosphoethanolamine cytidylyltransferase 2 integrates DAG metabolism and TBK1 activation to regulate antiviral innate immunity.
by: Lai, Wencong, et al.
Published: (2026)

Self-Carrier Nanoagonist Enabling Positive Feedback Regulation of Cuproptosis-Immunity for Potent Antitumor Therapy.
by: Jiang, Minhao, et al.
Published: (2026)