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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Science advances
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40053579/ |
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| _version_ | 1868266234551730178 |
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| author | Wöhlbrand, Lars Dörries, Marvin Siani, Roberto Medrano-Soto, Arturo Schnaars, Vanessa Schumacher, Julian Hilbers, Christina Thies, Daniela Kube, Michael Reinhardt, Richard Schloter, Michael Saier, Milton H Winklhofer, Michael Rabus, Ralf |
| author_facet | Wöhlbrand, Lars Dörries, Marvin Siani, Roberto Medrano-Soto, Arturo Schnaars, Vanessa Schumacher, Julian Hilbers, Christina Thies, Daniela Kube, Michael Reinhardt, Richard Schloter, Michael Saier, Milton H Winklhofer, Michael Rabus, Ralf Wöhlbrand, Lars Dörries, Marvin Siani, Roberto Medrano-Soto, Arturo Schnaars, Vanessa Schumacher, Julian Hilbers, Christina Thies, Daniela Kube, Michael Reinhardt, Richard Schloter, Michael Saier, Milton H Winklhofer, Michael Rabus, Ralf |
| collection | PubMed - marine biology |
| contents | Key role of in C/S cycles of marine sediments is based on congeneric catabolic-regulatory networks. Wöhlbrand, Lars Dörries, Marvin Siani, Roberto Medrano-Soto, Arturo Schnaars, Vanessa Schumacher, Julian Hilbers, Christina Thies, Daniela Kube, Michael Reinhardt, Richard Schloter, Michael Saier, Milton H Winklhofer, Michael Rabus, Ralf Geologic Sediments Deltaproteobacteria Gene Regulatory Networks Sulfur Carbon Cycle Carbon Phylogeny Metagenome Genome, Bacterial Marine sediments are highly bioactive habitats, where sulfate-reducing bacteria contribute substantially to seabed carbon cycling by oxidizing ~77 Tmol C year. This remarkable activity is largely attributable to the deltaproteobacterial family of complete oxidizers (to CO), which our biogeography focused meta-analysis verified as cosmopolitan. However, the catabolic/regulatory networks underlying this ecophysiological feat at the thermodynamic limit are essentially unknown. Integrating cultivation-based (80 conditions) proteogenomics of six representative spp., we identify molecular commonalities explaining the family's environmental relevance and success. genomes are specifically enriched in substrate uptake, degradation capacities, and regulatory functions including fine-tuned sulfate uptake. Conserved gene arrangements and shared regulatory patterns translate into strikingly similar (sub-)proteome profiles. From 319 proteins, we constructed a meta-network for catabolizing 35 substrates. Therefrom, we defined a characteristic gene subset, which we found prevalent in metagenomes of organic-rich, marine sediments. These genes are promising targets to advance our mechanistic understanding of -driven biogeochemical processes in marine sediments and beyond. |
| format | Artículo científico |
| id | pubmed_40053579 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Science advances |
| record_format | pubmed |
| spellingShingle | Key role of in C/S cycles of marine sediments is based on congeneric catabolic-regulatory networks. Wöhlbrand, Lars Dörries, Marvin Siani, Roberto Medrano-Soto, Arturo Schnaars, Vanessa Schumacher, Julian Hilbers, Christina Thies, Daniela Kube, Michael Reinhardt, Richard Schloter, Michael Saier, Milton H Winklhofer, Michael Rabus, Ralf Geologic Sediments Deltaproteobacteria Gene Regulatory Networks Sulfur Carbon Cycle Carbon Phylogeny Metagenome Genome, Bacterial Key role of in C/S cycles of marine sediments is based on congeneric catabolic-regulatory networks. Wöhlbrand, Lars Dörries, Marvin Siani, Roberto Medrano-Soto, Arturo Schnaars, Vanessa Schumacher, Julian Hilbers, Christina Thies, Daniela Kube, Michael Reinhardt, Richard Schloter, Michael Saier, Milton H Winklhofer, Michael Rabus, Ralf Geologic Sediments Deltaproteobacteria Gene Regulatory Networks Sulfur Carbon Cycle Carbon Phylogeny Metagenome Genome, Bacterial Marine sediments are highly bioactive habitats, where sulfate-reducing bacteria contribute substantially to seabed carbon cycling by oxidizing ~77 Tmol C year. This remarkable activity is largely attributable to the deltaproteobacterial family of complete oxidizers (to CO), which our biogeography focused meta-analysis verified as cosmopolitan. However, the catabolic/regulatory networks underlying this ecophysiological feat at the thermodynamic limit are essentially unknown. Integrating cultivation-based (80 conditions) proteogenomics of six representative spp., we identify molecular commonalities explaining the family's environmental relevance and success. genomes are specifically enriched in substrate uptake, degradation capacities, and regulatory functions including fine-tuned sulfate uptake. Conserved gene arrangements and shared regulatory patterns translate into strikingly similar (sub-)proteome profiles. From 319 proteins, we constructed a meta-network for catabolizing 35 substrates. Therefrom, we defined a characteristic gene subset, which we found prevalent in metagenomes of organic-rich, marine sediments. These genes are promising targets to advance our mechanistic understanding of -driven biogeochemical processes in marine sediments and beyond. |
| title | Key role of in C/S cycles of marine sediments is based on congeneric catabolic-regulatory networks. |
| topic | Geologic Sediments Deltaproteobacteria Gene Regulatory Networks Sulfur Carbon Cycle Carbon Phylogeny Metagenome Genome, Bacterial |
| url | https://pubmed.ncbi.nlm.nih.gov/40053579/ |