Chronic exposure to palm oil mill effluent induces oxidative stress and histopathological changes in zebrafish (Danio rerio).
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| Natura: | Artículo científico |
| Lingua: | en |
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Journal of hazardous materials
2025
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| author | Zulfahmi, Ilham Batubara, Agung Setia Perdana, Adli Waliul Rahmah, Alvi Nafis, Badratun Ali, Rizwan Nasution, Ayu Wulandari Iqbal, Teuku Haris Nur, Firman M Sari, Widya Sumon, Kizar Ahmed Rahman, Mohammad Mahmudur |
| author_facet | Zulfahmi, Ilham Batubara, Agung Setia Perdana, Adli Waliul Rahmah, Alvi Nafis, Badratun Ali, Rizwan Nasution, Ayu Wulandari Iqbal, Teuku Haris Nur, Firman M Sari, Widya Sumon, Kizar Ahmed Rahman, Mohammad Mahmudur Zulfahmi, Ilham Batubara, Agung Setia Perdana, Adli Waliul Rahmah, Alvi Nafis, Badratun Ali, Rizwan Nasution, Ayu Wulandari Iqbal, Teuku Haris Nur, Firman M Sari, Widya Sumon, Kizar Ahmed Rahman, Mohammad Mahmudur |
| collection | PubMed - marine biology |
| contents | Chronic exposure to palm oil mill effluent induces oxidative stress and histopathological changes in zebrafish (Danio rerio). Zulfahmi, Ilham Batubara, Agung Setia Perdana, Adli Waliul Rahmah, Alvi Nafis, Badratun Ali, Rizwan Nasution, Ayu Wulandari Iqbal, Teuku Haris Nur, Firman M Sari, Widya Sumon, Kizar Ahmed Rahman, Mohammad Mahmudur Animals Zebrafish Oxidative Stress Gills Palm Oil Liver Water Pollutants, Chemical Industrial Waste Superoxide Dismutase Catalase Malondialdehyde Plant Oils Glutathione Transferase Wastewater Several studies have revealed that Palm Oil Mill Effluent (POME) adversely affects fish health systems in various ways. However, further studies on oxidative stress and histopathological changes in fish tissues exposed to POME are essential so that a more comprehensive and detailed understanding of its toxicity is attained. Subsequently, this study investigated oxidative stress indicators, including malondialdehyde (MDA) content and activities of antioxidant enzymes, as well as histological changes in zebrafish (Danio rerio) tissues after chronic exposure to POME. The results showed a significant increase in MDA content by up to 122 % in gills and 351 % in liver, while catalase (CAT) activity rose by 70 % in gills and 170 % in liver. Glutathione S-transferase (GST) activity was significantly reduced by 50 % in both tissues, while superoxide dismutase (SOD) activity increased by 162 % in the liver, yet showed no significant change in gills. Histological analysis revealed mild to severe alterations in gills (e.g., hyperplasia, hypertrophy, hemorrhage, and necrosis) and liver (e.g., hepatocyte shrinkage, congestion, hydropic degeneration, and necrosis) at higher POME concentrations and longer exposure durations. These findings suggest that oxidative stress markers and histopathological changes potentially serve as early warning indicators for: firstly, assessing POME contamination in aquatic environments; and secondly, evaluating the effectiveness of wastewater treatment systems. |
| format | Artículo científico |
| id | pubmed_40054186 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of hazardous materials |
| record_format | pubmed |
| spellingShingle | Chronic exposure to palm oil mill effluent induces oxidative stress and histopathological changes in zebrafish (Danio rerio). Zulfahmi, Ilham Batubara, Agung Setia Perdana, Adli Waliul Rahmah, Alvi Nafis, Badratun Ali, Rizwan Nasution, Ayu Wulandari Iqbal, Teuku Haris Nur, Firman M Sari, Widya Sumon, Kizar Ahmed Rahman, Mohammad Mahmudur Animals Zebrafish Oxidative Stress Gills Palm Oil Liver Water Pollutants, Chemical Industrial Waste Superoxide Dismutase Catalase Malondialdehyde Plant Oils Glutathione Transferase Wastewater Chronic exposure to palm oil mill effluent induces oxidative stress and histopathological changes in zebrafish (Danio rerio). Zulfahmi, Ilham Batubara, Agung Setia Perdana, Adli Waliul Rahmah, Alvi Nafis, Badratun Ali, Rizwan Nasution, Ayu Wulandari Iqbal, Teuku Haris Nur, Firman M Sari, Widya Sumon, Kizar Ahmed Rahman, Mohammad Mahmudur Animals Zebrafish Oxidative Stress Gills Palm Oil Liver Water Pollutants, Chemical Industrial Waste Superoxide Dismutase Catalase Malondialdehyde Plant Oils Glutathione Transferase Wastewater Several studies have revealed that Palm Oil Mill Effluent (POME) adversely affects fish health systems in various ways. However, further studies on oxidative stress and histopathological changes in fish tissues exposed to POME are essential so that a more comprehensive and detailed understanding of its toxicity is attained. Subsequently, this study investigated oxidative stress indicators, including malondialdehyde (MDA) content and activities of antioxidant enzymes, as well as histological changes in zebrafish (Danio rerio) tissues after chronic exposure to POME. The results showed a significant increase in MDA content by up to 122 % in gills and 351 % in liver, while catalase (CAT) activity rose by 70 % in gills and 170 % in liver. Glutathione S-transferase (GST) activity was significantly reduced by 50 % in both tissues, while superoxide dismutase (SOD) activity increased by 162 % in the liver, yet showed no significant change in gills. Histological analysis revealed mild to severe alterations in gills (e.g., hyperplasia, hypertrophy, hemorrhage, and necrosis) and liver (e.g., hepatocyte shrinkage, congestion, hydropic degeneration, and necrosis) at higher POME concentrations and longer exposure durations. These findings suggest that oxidative stress markers and histopathological changes potentially serve as early warning indicators for: firstly, assessing POME contamination in aquatic environments; and secondly, evaluating the effectiveness of wastewater treatment systems. |
| title | Chronic exposure to palm oil mill effluent induces oxidative stress and histopathological changes in zebrafish (Danio rerio). |
| topic | Animals Zebrafish Oxidative Stress Gills Palm Oil Liver Water Pollutants, Chemical Industrial Waste Superoxide Dismutase Catalase Malondialdehyde Plant Oils Glutathione Transferase Wastewater |
| url | https://pubmed.ncbi.nlm.nih.gov/40054186/ |