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Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.

Fuente: PubMed

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Bibliographic Details
Main Authors:	Cao, Yin, Huang, Sen, He, Yaohui, Zhang, Yuxiang, Chen, Simian, Huang, Mengxian, He, Fengming, Chen, Shutong, Wang, Di, Yang, Ziying, Zhao, Xinwei, Wang, Xiumin, Wu, Zhen, Ao, Mingtao, Qiu, Yingkun, Fang, Meijuan
Format:	Artículo científico
Language:	en
Published:	Bioorganic chemistry 2025
Subjects:	Humans Esophageal Squamous Cell Carcinoma Cyclin-Dependent Kinases Esophageal Neoplasms Antineoplastic Agents Protein Kinase Inhibitors Structure-Activity Relationship Cell Proliferation Molecular Structure Dose-Response Relationship, Drug Animals Drug Screening Assays, Antitumor Drug Discovery Mice Pyrimidines Mice, Nude Cell Line, Tumor
Online Access:	Acceder al recurso
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