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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Open biology
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40068811/ |
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| _version_ | 1868266232036196353 |
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| author | Modica, Maria Vittoria Leone, Serena Gerdol, Marco Greco, Samuele Aurelle, Didier Oliverio, Marco Fassio, Giulia El Koulali, Khadija Barrachina, Célia Dutertre, Sebastien |
| author_facet | Modica, Maria Vittoria Leone, Serena Gerdol, Marco Greco, Samuele Aurelle, Didier Oliverio, Marco Fassio, Giulia El Koulali, Khadija Barrachina, Célia Dutertre, Sebastien Modica, Maria Vittoria Leone, Serena Gerdol, Marco Greco, Samuele Aurelle, Didier Oliverio, Marco Fassio, Giulia El Koulali, Khadija Barrachina, Célia Dutertre, Sebastien |
| collection | PubMed - marine biology |
| contents | The proteotranscriptomic characterization of venom in the white seafan elucidates the evolution of Octocorallia arsenal. Modica, Maria Vittoria Leone, Serena Gerdol, Marco Greco, Samuele Aurelle, Didier Oliverio, Marco Fassio, Giulia El Koulali, Khadija Barrachina, Célia Dutertre, Sebastien Animals Cnidarian Venoms Anthozoa Evolution, Molecular Phylogeny Transcriptome Proteome Proteomics Sea Anemones Nematocyst All the members of the phylum Cnidaria are characterized by the production of venom in specialized structures, the nematocysts. Venom of jellyfish (Medusozoa) and sea anemones (Anthozoa) has been investigated since the 1970s, revealing a remarkable molecular diversity. Specifically, sea anemones harbour a rich repertoire of neurotoxic peptides, some of which have been developed in drug leads. However, venoms of the vast majority of Anthozoa species remain uncharacterized, particularly in the class Octocorallia. To fill this gap, we applied a proteo-transcriptomic approach to investigate venom composition in , a gorgonian species common in Mediterranean hard-bottom benthic communities. Our results highlighted the peculiarities of the venom of with respect to sea anemones, which is reflected in the presence of several toxins with novel folds, worthy of functional characterization. A comparative genomic survey across the octocoral radiation allowed us to generalize these findings and provided insights into the evolutionary history, molecular diversification patterns and putative adaptive roles of venom toxins. A comparison of whole-body and nematocyst proteomes revealed the presence of different cytolytic toxins inside and outside the nematocysts. Two instances of differential maturation patterns of toxin precursors were also identified, highlighting the intricate regulatory pathways underlying toxin expression. |
| format | Artículo científico |
| id | pubmed_40068811 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Open biology |
| record_format | pubmed |
| spellingShingle | The proteotranscriptomic characterization of venom in the white seafan elucidates the evolution of Octocorallia arsenal. Modica, Maria Vittoria Leone, Serena Gerdol, Marco Greco, Samuele Aurelle, Didier Oliverio, Marco Fassio, Giulia El Koulali, Khadija Barrachina, Célia Dutertre, Sebastien Animals Cnidarian Venoms Anthozoa Evolution, Molecular Phylogeny Transcriptome Proteome Proteomics Sea Anemones Nematocyst The proteotranscriptomic characterization of venom in the white seafan elucidates the evolution of Octocorallia arsenal. Modica, Maria Vittoria Leone, Serena Gerdol, Marco Greco, Samuele Aurelle, Didier Oliverio, Marco Fassio, Giulia El Koulali, Khadija Barrachina, Célia Dutertre, Sebastien Animals Cnidarian Venoms Anthozoa Evolution, Molecular Phylogeny Transcriptome Proteome Proteomics Sea Anemones Nematocyst All the members of the phylum Cnidaria are characterized by the production of venom in specialized structures, the nematocysts. Venom of jellyfish (Medusozoa) and sea anemones (Anthozoa) has been investigated since the 1970s, revealing a remarkable molecular diversity. Specifically, sea anemones harbour a rich repertoire of neurotoxic peptides, some of which have been developed in drug leads. However, venoms of the vast majority of Anthozoa species remain uncharacterized, particularly in the class Octocorallia. To fill this gap, we applied a proteo-transcriptomic approach to investigate venom composition in , a gorgonian species common in Mediterranean hard-bottom benthic communities. Our results highlighted the peculiarities of the venom of with respect to sea anemones, which is reflected in the presence of several toxins with novel folds, worthy of functional characterization. A comparative genomic survey across the octocoral radiation allowed us to generalize these findings and provided insights into the evolutionary history, molecular diversification patterns and putative adaptive roles of venom toxins. A comparison of whole-body and nematocyst proteomes revealed the presence of different cytolytic toxins inside and outside the nematocysts. Two instances of differential maturation patterns of toxin precursors were also identified, highlighting the intricate regulatory pathways underlying toxin expression. |
| title | The proteotranscriptomic characterization of venom in the white seafan elucidates the evolution of Octocorallia arsenal. |
| topic | Animals Cnidarian Venoms Anthozoa Evolution, Molecular Phylogeny Transcriptome Proteome Proteomics Sea Anemones Nematocyst |
| url | https://pubmed.ncbi.nlm.nih.gov/40068811/ |