RmZHD Surface-Displayed for High Efficiency and Low-Cost Degradation of Zearalenone.
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ACS applied bio materials
2025
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| author | Chen, Haoxiang Wang, Xiaoyu Ge, Hui Geng, Shichen Liu, Li Fang, Baishan Ren, Lei |
| author_facet | Chen, Haoxiang Wang, Xiaoyu Ge, Hui Geng, Shichen Liu, Li Fang, Baishan Ren, Lei Chen, Haoxiang Wang, Xiaoyu Ge, Hui Geng, Shichen Liu, Li Fang, Baishan Ren, Lei |
| collection | PubMed - marine biology |
| contents | RmZHD Surface-Displayed for High Efficiency and Low-Cost Degradation of Zearalenone. Chen, Haoxiang Wang, Xiaoyu Ge, Hui Geng, Shichen Liu, Li Fang, Baishan Ren, Lei Zearalenone Escherichia coli Biocompatible Materials Surface Properties Hydrolases Materials Testing Particle Size Biodegradation, Environmental Zearalenone (ZEN) is one of the most prevalent mycotoxins in the world, with estrogenic toxicity leading to significant annual economic losses and environmental pollution. RmZHD, a novel ZEN hydrolase, surpasses the efficiency of its predecessors but faces challenges in large-scale industrial application. In this work, an engineered that can degrade zearalenone is constructed based on synthetic biology and surface display methods. It can degrade 94% of zearalenone at 30 °C in 1 h (the final concentration was 1.898 μg/mL) and effectively degrade ZEN-derived toxins, including zearalanone, β-zearalanol, α-zearalenol, and β-zearalenol. This engineered requires no additional manipulation for the surface display of RmZHD and is cost-effective to produce. Moreover, it exhibits the capability to degrade ZEN in maize feed while concurrently mitigating inflammation in animal reproductive and digestive organs. In summary, the engineered with surface-displayed RmZHD presents a novel approach for environmentally sustainable and industrial-scale treatment of ZEN. |
| format | Artículo científico |
| id | pubmed_40080174 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | ACS applied bio materials |
| record_format | pubmed |
| spellingShingle | RmZHD Surface-Displayed for High Efficiency and Low-Cost Degradation of Zearalenone. Chen, Haoxiang Wang, Xiaoyu Ge, Hui Geng, Shichen Liu, Li Fang, Baishan Ren, Lei Zearalenone Escherichia coli Biocompatible Materials Surface Properties Hydrolases Materials Testing Particle Size Biodegradation, Environmental RmZHD Surface-Displayed for High Efficiency and Low-Cost Degradation of Zearalenone. Chen, Haoxiang Wang, Xiaoyu Ge, Hui Geng, Shichen Liu, Li Fang, Baishan Ren, Lei Zearalenone Escherichia coli Biocompatible Materials Surface Properties Hydrolases Materials Testing Particle Size Biodegradation, Environmental Zearalenone (ZEN) is one of the most prevalent mycotoxins in the world, with estrogenic toxicity leading to significant annual economic losses and environmental pollution. RmZHD, a novel ZEN hydrolase, surpasses the efficiency of its predecessors but faces challenges in large-scale industrial application. In this work, an engineered that can degrade zearalenone is constructed based on synthetic biology and surface display methods. It can degrade 94% of zearalenone at 30 °C in 1 h (the final concentration was 1.898 μg/mL) and effectively degrade ZEN-derived toxins, including zearalanone, β-zearalanol, α-zearalenol, and β-zearalenol. This engineered requires no additional manipulation for the surface display of RmZHD and is cost-effective to produce. Moreover, it exhibits the capability to degrade ZEN in maize feed while concurrently mitigating inflammation in animal reproductive and digestive organs. In summary, the engineered with surface-displayed RmZHD presents a novel approach for environmentally sustainable and industrial-scale treatment of ZEN. |
| title | RmZHD Surface-Displayed for High Efficiency and Low-Cost Degradation of Zearalenone. |
| topic | Zearalenone Escherichia coli Biocompatible Materials Surface Properties Hydrolases Materials Testing Particle Size Biodegradation, Environmental |
| url | https://pubmed.ncbi.nlm.nih.gov/40080174/ |