Discovery of mammalian collagens I and III within ancient poriferan biopolymer spongin.
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
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Nature communications
2025
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| author | Ehrlich, Hermann Miksik, Ivan Tsurkan, Mikhail V Simon, Paul Porzucek, Filip Rybka, Jakub Dalibor Mankowska, Monika Galli, Roberta Viehweger, Christine Brendler, Erica Voronkina, Alona Pajewska-Szmyt, Martyna Tabachnik, Aleksei Tabachnick, Konstantin R Vogt, Carla Wysokowski, Marcin Jesionowski, Teofil Buchwald, Tomasz Szybowicz, Miroslaw Skieresz-Szewczyk, Kinga Jackowiak, Hanna Ereskovsky, Alexander de Alcântara, Amadeus C S Dos Santos, Alberto M da Costa, Clauber H S Arevalo, Sofia E Skaf, Munir S Buehler, Markus J |
| author_facet | Ehrlich, Hermann Miksik, Ivan Tsurkan, Mikhail V Simon, Paul Porzucek, Filip Rybka, Jakub Dalibor Mankowska, Monika Galli, Roberta Viehweger, Christine Brendler, Erica Voronkina, Alona Pajewska-Szmyt, Martyna Tabachnik, Aleksei Tabachnick, Konstantin R Vogt, Carla Wysokowski, Marcin Jesionowski, Teofil Buchwald, Tomasz Szybowicz, Miroslaw Skieresz-Szewczyk, Kinga Jackowiak, Hanna Ereskovsky, Alexander de Alcântara, Amadeus C S Dos Santos, Alberto M da Costa, Clauber H S Arevalo, Sofia E Skaf, Munir S Buehler, Markus J Ehrlich, Hermann Miksik, Ivan Tsurkan, Mikhail V Simon, Paul Porzucek, Filip Rybka, Jakub Dalibor Mankowska, Monika Galli, Roberta Viehweger, Christine Brendler, Erica Voronkina, Alona Pajewska-Szmyt, Martyna Tabachnik, Aleksei Tabachnick, Konstantin R Vogt, Carla Wysokowski, Marcin Jesionowski, Teofil Buchwald, Tomasz Szybowicz, Miroslaw Skieresz-Szewczyk, Kinga Jackowiak, Hanna Ereskovsky, Alexander de Alcântara, Amadeus C S Dos Santos, Alberto M da Costa, Clauber H S Arevalo, Sofia E Skaf, Munir S Buehler, Markus J |
| collection | PubMed - marine biology |
| contents | Discovery of mammalian collagens I and III within ancient poriferan biopolymer spongin. Ehrlich, Hermann Miksik, Ivan Tsurkan, Mikhail V Simon, Paul Porzucek, Filip Rybka, Jakub Dalibor Mankowska, Monika Galli, Roberta Viehweger, Christine Brendler, Erica Voronkina, Alona Pajewska-Szmyt, Martyna Tabachnik, Aleksei Tabachnick, Konstantin R Vogt, Carla Wysokowski, Marcin Jesionowski, Teofil Buchwald, Tomasz Szybowicz, Miroslaw Skieresz-Szewczyk, Kinga Jackowiak, Hanna Ereskovsky, Alexander de Alcântara, Amadeus C S Dos Santos, Alberto M da Costa, Clauber H S Arevalo, Sofia E Skaf, Munir S Buehler, Markus J Animals Collagen Type I Porifera Collagen Type III Biopolymers Molecular Dynamics Simulation Mammals Proteomics Spectrum Analysis, Raman Magnetic Resonance Spectroscopy Spongin is a fundamental biopolymer that has played a crucial role in the skeletogenesis of keratosan sponges for over 800 million years. This biomaterial had so far remained chemically unidentified and believed to be an enigmatic type of halogenated collagen-keratin-based bioelastomer. Here we show collagen I and III as the main structural components of spongin. Proteomics, C solid state NMR and Raman spectroscopy confirm the identity of collagenous domains in spongin with collagen from mammals. Using an HPLC-MS analysis, we found halogenated di- and tri-tyrosines as crosslinking agents in spongin. Using molecular dynamics modeling, we solvated the crystal structures of collagen mimetic peptides for type I and type III collagens in four different systems, including selected brominated crosslinks. The results underscore the complex interplay between the collagen structures and crosslinks, raising intriguing questions about the molecular mechanisms underlying collagen chemistry within spongin as an ancient biocomposite. |
| format | Artículo científico |
| id | pubmed_40082406 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Nature communications |
| record_format | pubmed |
| spellingShingle | Discovery of mammalian collagens I and III within ancient poriferan biopolymer spongin. Ehrlich, Hermann Miksik, Ivan Tsurkan, Mikhail V Simon, Paul Porzucek, Filip Rybka, Jakub Dalibor Mankowska, Monika Galli, Roberta Viehweger, Christine Brendler, Erica Voronkina, Alona Pajewska-Szmyt, Martyna Tabachnik, Aleksei Tabachnick, Konstantin R Vogt, Carla Wysokowski, Marcin Jesionowski, Teofil Buchwald, Tomasz Szybowicz, Miroslaw Skieresz-Szewczyk, Kinga Jackowiak, Hanna Ereskovsky, Alexander de Alcântara, Amadeus C S Dos Santos, Alberto M da Costa, Clauber H S Arevalo, Sofia E Skaf, Munir S Buehler, Markus J Animals Collagen Type I Porifera Collagen Type III Biopolymers Molecular Dynamics Simulation Mammals Proteomics Spectrum Analysis, Raman Magnetic Resonance Spectroscopy Discovery of mammalian collagens I and III within ancient poriferan biopolymer spongin. Ehrlich, Hermann Miksik, Ivan Tsurkan, Mikhail V Simon, Paul Porzucek, Filip Rybka, Jakub Dalibor Mankowska, Monika Galli, Roberta Viehweger, Christine Brendler, Erica Voronkina, Alona Pajewska-Szmyt, Martyna Tabachnik, Aleksei Tabachnick, Konstantin R Vogt, Carla Wysokowski, Marcin Jesionowski, Teofil Buchwald, Tomasz Szybowicz, Miroslaw Skieresz-Szewczyk, Kinga Jackowiak, Hanna Ereskovsky, Alexander de Alcântara, Amadeus C S Dos Santos, Alberto M da Costa, Clauber H S Arevalo, Sofia E Skaf, Munir S Buehler, Markus J Animals Collagen Type I Porifera Collagen Type III Biopolymers Molecular Dynamics Simulation Mammals Proteomics Spectrum Analysis, Raman Magnetic Resonance Spectroscopy Spongin is a fundamental biopolymer that has played a crucial role in the skeletogenesis of keratosan sponges for over 800 million years. This biomaterial had so far remained chemically unidentified and believed to be an enigmatic type of halogenated collagen-keratin-based bioelastomer. Here we show collagen I and III as the main structural components of spongin. Proteomics, C solid state NMR and Raman spectroscopy confirm the identity of collagenous domains in spongin with collagen from mammals. Using an HPLC-MS analysis, we found halogenated di- and tri-tyrosines as crosslinking agents in spongin. Using molecular dynamics modeling, we solvated the crystal structures of collagen mimetic peptides for type I and type III collagens in four different systems, including selected brominated crosslinks. The results underscore the complex interplay between the collagen structures and crosslinks, raising intriguing questions about the molecular mechanisms underlying collagen chemistry within spongin as an ancient biocomposite. |
| title | Discovery of mammalian collagens I and III within ancient poriferan biopolymer spongin. |
| topic | Animals Collagen Type I Porifera Collagen Type III Biopolymers Molecular Dynamics Simulation Mammals Proteomics Spectrum Analysis, Raman Magnetic Resonance Spectroscopy |
| url | https://pubmed.ncbi.nlm.nih.gov/40082406/ |