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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Organic letters
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40103516/ |
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| _version_ | 1868266228861108226 |
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| author | Hao, Xingkun Wang, Zong-Jie Shi, Xingxing Liu, Yang Yan, Ping Yang, Qingsheng Ren, Xiangmei Li, Xiaoju Sui, Haiyan Li, Feng Zhang, Youming Bian, Xiaoying Zhou, Haibo |
| author_facet | Hao, Xingkun Wang, Zong-Jie Shi, Xingxing Liu, Yang Yan, Ping Yang, Qingsheng Ren, Xiangmei Li, Xiaoju Sui, Haiyan Li, Feng Zhang, Youming Bian, Xiaoying Zhou, Haibo Hao, Xingkun Wang, Zong-Jie Shi, Xingxing Liu, Yang Yan, Ping Yang, Qingsheng Ren, Xiangmei Li, Xiaoju Sui, Haiyan Li, Feng Zhang, Youming Bian, Xiaoying Zhou, Haibo |
| collection | PubMed - marine biology |
| contents | Genome Mining and Targeted Discovery of Twistane-Containing Angucyclinones from Marine XSA2. Hao, Xingkun Wang, Zong-Jie Shi, Xingxing Liu, Yang Yan, Ping Yang, Qingsheng Ren, Xiangmei Li, Xiaoju Sui, Haiyan Li, Feng Zhang, Youming Bian, Xiaoying Zhou, Haibo Streptomyces Molecular Structure Multigene Family Anthraquinones Crystallography, X-Ray Genome, Bacterial Angucyclines and Angucyclinones Genome mining of a type II PKS biosynthetic gene cluster from marine XSA2 resulted in the discovery of 12 angucyclinone derivatives, including nine new phaeomycins A-I (-) and three known analogs (-). Phaeomycin A () contains a unique phthalide moiety connected to a rare twistane skeleton that has not been previously identified in natural products. The chemical structures of the isolated compounds were established via extensive spectroscopic and X-ray crystal-lographic analyses. A plausible biosynthetic pathway for - was proposed based on bioinformatic analysis. |
| format | Artículo científico |
| id | pubmed_40103516 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Organic letters |
| record_format | pubmed |
| spellingShingle | Genome Mining and Targeted Discovery of Twistane-Containing Angucyclinones from Marine XSA2. Hao, Xingkun Wang, Zong-Jie Shi, Xingxing Liu, Yang Yan, Ping Yang, Qingsheng Ren, Xiangmei Li, Xiaoju Sui, Haiyan Li, Feng Zhang, Youming Bian, Xiaoying Zhou, Haibo Streptomyces Molecular Structure Multigene Family Anthraquinones Crystallography, X-Ray Genome, Bacterial Angucyclines and Angucyclinones Genome Mining and Targeted Discovery of Twistane-Containing Angucyclinones from Marine XSA2. Hao, Xingkun Wang, Zong-Jie Shi, Xingxing Liu, Yang Yan, Ping Yang, Qingsheng Ren, Xiangmei Li, Xiaoju Sui, Haiyan Li, Feng Zhang, Youming Bian, Xiaoying Zhou, Haibo Streptomyces Molecular Structure Multigene Family Anthraquinones Crystallography, X-Ray Genome, Bacterial Angucyclines and Angucyclinones Genome mining of a type II PKS biosynthetic gene cluster from marine XSA2 resulted in the discovery of 12 angucyclinone derivatives, including nine new phaeomycins A-I (-) and three known analogs (-). Phaeomycin A () contains a unique phthalide moiety connected to a rare twistane skeleton that has not been previously identified in natural products. The chemical structures of the isolated compounds were established via extensive spectroscopic and X-ray crystal-lographic analyses. A plausible biosynthetic pathway for - was proposed based on bioinformatic analysis. |
| title | Genome Mining and Targeted Discovery of Twistane-Containing Angucyclinones from Marine XSA2. |
| topic | Streptomyces Molecular Structure Multigene Family Anthraquinones Crystallography, X-Ray Genome, Bacterial Angucyclines and Angucyclinones |
| url | https://pubmed.ncbi.nlm.nih.gov/40103516/ |