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| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Phytochemistry
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40127881/ |
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Inhaltsangabe:
- Ircindrimanes A-I, nine undescribed meroterpenoids with cytotoxic activities from the marine sponge Ircinia sp. Zhang, Wenjie Chen, Yu Ren, Jinjin Li, Xiaobin Tang, Xuli Han, Xiao Li, Guoqiang Animals Porifera Humans Drug Screening Assays, Antitumor Antineoplastic Agents Terpenes Molecular Structure Cell Line, Tumor Cell Proliferation Structure-Activity Relationship Dose-Response Relationship, Drug Molecular Conformation Nine undescribed meroterpenoids, named ircindrimanes A-I (1-9), were isolated from the marine sponge Ircinia sp. collected in the South China Sea. Their planar structures were determined by NMR, HRESIMS, UV spectroscopic data. The absolute configurations were established through DP4+ analysis, ECD calculations and single crystal X-ray diffraction. Biological evaluation indicated that compounds 7 and 8 exhibited moderate to strong cytotoxic activities towards several cancer cell lines.