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| Format: | Artículo científico |
| Sprache: | en |
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Biology
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40136530/ |
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| _version_ | 1868266226136907777 |
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| author | Mehreen, Afshan Faisal, Muhammad Zulfiqar, Bilal Hays, Deli Dhananjaya, Kavishka Yaseen, Faiza Liang, Yujun |
| author_facet | Mehreen, Afshan Faisal, Muhammad Zulfiqar, Bilal Hays, Deli Dhananjaya, Kavishka Yaseen, Faiza Liang, Yujun Mehreen, Afshan Faisal, Muhammad Zulfiqar, Bilal Hays, Deli Dhananjaya, Kavishka Yaseen, Faiza Liang, Yujun |
| collection | PubMed - marine biology |
| contents | Connecting Bone Remodeling and Regeneration: Unraveling Hormones and Signaling Pathways. Mehreen, Afshan Faisal, Muhammad Zulfiqar, Bilal Hays, Deli Dhananjaya, Kavishka Yaseen, Faiza Liang, Yujun Recent advancements in tissue engineering and stem cell science have positioned bone disease treatment as a promising frontier in regenerative medicine. This review explores the hormonal and signaling pathways critical to bone regeneration, with a focus on their clinical relevance. Key endocrine factors, including thyroid hormones (T3 and T4), insulin-like growth factor 1 (IGF-1), bone morphogenetic proteins (BMPs), parathyroid hormone (PTH), calcitonin, and fibroblast growth factor 23 (FGF23), play pivotal roles in bone remodeling by regulating osteoblast activity, bone resorption, and mineralization. These factors primarily act through the /β-catenin, BMP, and FGF signaling pathways, which govern bone repair and regeneration. While animal models, such as axolotls, zebrafish, and , provide valuable findings about these mechanisms, translating these findings into human applications presents challenges. This review underscores the therapeutic potential of modulating these hormonal networks to enhance bone regeneration while cautioning against possible adverse effects, such as uncontrolled tissue proliferation or metabolic imbalances. By integrating knowledge from regenerative models, this work provides a foundation for optimizing hormone-based therapies for clinical applications in bone repair and disease treatment. |
| format | Artículo científico |
| id | pubmed_40136530 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Biology |
| record_format | pubmed |
| spellingShingle | Connecting Bone Remodeling and Regeneration: Unraveling Hormones and Signaling Pathways. Mehreen, Afshan Faisal, Muhammad Zulfiqar, Bilal Hays, Deli Dhananjaya, Kavishka Yaseen, Faiza Liang, Yujun Connecting Bone Remodeling and Regeneration: Unraveling Hormones and Signaling Pathways. Mehreen, Afshan Faisal, Muhammad Zulfiqar, Bilal Hays, Deli Dhananjaya, Kavishka Yaseen, Faiza Liang, Yujun Recent advancements in tissue engineering and stem cell science have positioned bone disease treatment as a promising frontier in regenerative medicine. This review explores the hormonal and signaling pathways critical to bone regeneration, with a focus on their clinical relevance. Key endocrine factors, including thyroid hormones (T3 and T4), insulin-like growth factor 1 (IGF-1), bone morphogenetic proteins (BMPs), parathyroid hormone (PTH), calcitonin, and fibroblast growth factor 23 (FGF23), play pivotal roles in bone remodeling by regulating osteoblast activity, bone resorption, and mineralization. These factors primarily act through the /β-catenin, BMP, and FGF signaling pathways, which govern bone repair and regeneration. While animal models, such as axolotls, zebrafish, and , provide valuable findings about these mechanisms, translating these findings into human applications presents challenges. This review underscores the therapeutic potential of modulating these hormonal networks to enhance bone regeneration while cautioning against possible adverse effects, such as uncontrolled tissue proliferation or metabolic imbalances. By integrating knowledge from regenerative models, this work provides a foundation for optimizing hormone-based therapies for clinical applications in bone repair and disease treatment. |
| title | Connecting Bone Remodeling and Regeneration: Unraveling Hormones and Signaling Pathways. |
| url | https://pubmed.ncbi.nlm.nih.gov/40136530/ |