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| Auteurs principaux: | , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Toxins
2025
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| Sujets: | |
| Accès en ligne: | https://pubmed.ncbi.nlm.nih.gov/40137882/ |
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| _version_ | 1868266226132713472 |
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| author | Balson, Jordan Boudreau, Jeffrey R Chin-Sang, Ian D Wang, Yuxiang Lefebvre, Daniel D |
| author_facet | Balson, Jordan Boudreau, Jeffrey R Chin-Sang, Ian D Wang, Yuxiang Lefebvre, Daniel D Balson, Jordan Boudreau, Jeffrey R Chin-Sang, Ian D Wang, Yuxiang Lefebvre, Daniel D |
| collection | PubMed - marine biology |
| contents | Tolerance to a Diet of Toxic in . Balson, Jordan Boudreau, Jeffrey R Chin-Sang, Ian D Wang, Yuxiang Lefebvre, Daniel D Animals Caenorhabditis elegans Microcystis Microcystins Diet Marine Toxins Longevity Harmful Algal Bloom Reported incidences of cyanobacterial harmful algal blooms (CHABs) are increasing across the world due to climate change and nutrient loading, dominating freshwater ecosystems and producing dangerous cyanotoxins that cause ecological damage. is one of the most common species of cyanobacteria; it produces hepatotoxic and neurotoxic microcystin-LR. The ecological and human impact of algal blooms is immense, and traditional CHAB remediation methods are not always adequate in eutrophic regions such as Lake Erie in North America. As a result, a proactive, targeted approach is needed to bioremediate cyanobacteria in their pre-colonial stages. Nematodes, such as the model organism , are potential candidates for bioremediating cyanobacteria such as . have metabolic pathways that could detoxify microcystin-LR and enable tolerance to cyanobacteria in nature. We analyzed health and fat accumulation on a diet of toxic and found that can ingest, digest, metabolize, and survive off of this diet. The mean lifespans of the worm populations were only slightly different at 20.68 ± 0.35 (mean ± S.E.M) and 17.89 ± 0.40 when fed and toxic , respectively. In addition, a diet of toxic compared to did not have any significant impact on pharyngeal pumping (304.2 ± 9.3 versus 330.0 ± 10.4 pumps/min), dauer response (86.3 ± 1.0 versus 83.65 ± 1.0% in dauer), mobility (209.25 ± 7.0 versus 210.15 ± 4.4 thrashes/min), or SKN-1 expression based on SKN1::GFP fluorescence measurements. Overall, a diet of toxic was able to sustain development, and was tolerant of it. These results suggest that and similar nematodes could be viable candidates for cyanobacterial bioremediation. |
| format | Artículo científico |
| id | pubmed_40137882 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Toxins |
| record_format | pubmed |
| spellingShingle | Tolerance to a Diet of Toxic in . Balson, Jordan Boudreau, Jeffrey R Chin-Sang, Ian D Wang, Yuxiang Lefebvre, Daniel D Animals Caenorhabditis elegans Microcystis Microcystins Diet Marine Toxins Longevity Harmful Algal Bloom Tolerance to a Diet of Toxic in . Balson, Jordan Boudreau, Jeffrey R Chin-Sang, Ian D Wang, Yuxiang Lefebvre, Daniel D Animals Caenorhabditis elegans Microcystis Microcystins Diet Marine Toxins Longevity Harmful Algal Bloom Reported incidences of cyanobacterial harmful algal blooms (CHABs) are increasing across the world due to climate change and nutrient loading, dominating freshwater ecosystems and producing dangerous cyanotoxins that cause ecological damage. is one of the most common species of cyanobacteria; it produces hepatotoxic and neurotoxic microcystin-LR. The ecological and human impact of algal blooms is immense, and traditional CHAB remediation methods are not always adequate in eutrophic regions such as Lake Erie in North America. As a result, a proactive, targeted approach is needed to bioremediate cyanobacteria in their pre-colonial stages. Nematodes, such as the model organism , are potential candidates for bioremediating cyanobacteria such as . have metabolic pathways that could detoxify microcystin-LR and enable tolerance to cyanobacteria in nature. We analyzed health and fat accumulation on a diet of toxic and found that can ingest, digest, metabolize, and survive off of this diet. The mean lifespans of the worm populations were only slightly different at 20.68 ± 0.35 (mean ± S.E.M) and 17.89 ± 0.40 when fed and toxic , respectively. In addition, a diet of toxic compared to did not have any significant impact on pharyngeal pumping (304.2 ± 9.3 versus 330.0 ± 10.4 pumps/min), dauer response (86.3 ± 1.0 versus 83.65 ± 1.0% in dauer), mobility (209.25 ± 7.0 versus 210.15 ± 4.4 thrashes/min), or SKN-1 expression based on SKN1::GFP fluorescence measurements. Overall, a diet of toxic was able to sustain development, and was tolerant of it. These results suggest that and similar nematodes could be viable candidates for cyanobacterial bioremediation. |
| title | Tolerance to a Diet of Toxic in . |
| topic | Animals Caenorhabditis elegans Microcystis Microcystins Diet Marine Toxins Longevity Harmful Algal Bloom |
| url | https://pubmed.ncbi.nlm.nih.gov/40137882/ |