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| Natura: | Artículo científico |
| Lingua: | en |
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Archives of toxicology
2025
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| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/40137953/ |
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| author | Behr, Anne-Cathrin Fæste, Christiane Kruse Azqueta, Amaya Tavares, Ana M Spyropoulou, Anastasia Solhaug, Anita Olsen, Ann-Karin Vettorazzi, Ariane Mertens, Birgit Zegura, Bojana Streel, Camille Ndiaye, Dieynaba Spilioti, Eliana Dubreil, Estelle Buratti, Franca Maria Crudo, Francesco Eriksen, Gunnar Sundstøl Snapkow, Igor Teixeira, João Paulo Rasinger, Josef D Sanders, Julie Machera, Kyriaki Ivanova, Lada Gaté, Laurent Le Hegarat, Ludovic Novak, Matjaz Smith, Nicola M Tait, Sabrina Fraga, Sónia Hager, Sonja Marko, Doris Braeuning, Albert Louro, Henriqueta Silva, Maria João Dirven, Hubert Dietrich, Jessica |
| author_facet | Behr, Anne-Cathrin Fæste, Christiane Kruse Azqueta, Amaya Tavares, Ana M Spyropoulou, Anastasia Solhaug, Anita Olsen, Ann-Karin Vettorazzi, Ariane Mertens, Birgit Zegura, Bojana Streel, Camille Ndiaye, Dieynaba Spilioti, Eliana Dubreil, Estelle Buratti, Franca Maria Crudo, Francesco Eriksen, Gunnar Sundstøl Snapkow, Igor Teixeira, João Paulo Rasinger, Josef D Sanders, Julie Machera, Kyriaki Ivanova, Lada Gaté, Laurent Le Hegarat, Ludovic Novak, Matjaz Smith, Nicola M Tait, Sabrina Fraga, Sónia Hager, Sonja Marko, Doris Braeuning, Albert Louro, Henriqueta Silva, Maria João Dirven, Hubert Dietrich, Jessica Behr, Anne-Cathrin Fæste, Christiane Kruse Azqueta, Amaya Tavares, Ana M Spyropoulou, Anastasia Solhaug, Anita Olsen, Ann-Karin Vettorazzi, Ariane Mertens, Birgit Zegura, Bojana Streel, Camille Ndiaye, Dieynaba Spilioti, Eliana Dubreil, Estelle Buratti, Franca Maria Crudo, Francesco Eriksen, Gunnar Sundstøl Snapkow, Igor Teixeira, João Paulo Rasinger, Josef D Sanders, Julie Machera, Kyriaki Ivanova, Lada Gaté, Laurent Le Hegarat, Ludovic Novak, Matjaz Smith, Nicola M Tait, Sabrina Fraga, Sónia Hager, Sonja Marko, Doris Braeuning, Albert Louro, Henriqueta Silva, Maria João Dirven, Hubert Dietrich, Jessica |
| collection | PubMed - marine biology |
| contents | Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health. Behr, Anne-Cathrin Fæste, Christiane Kruse Azqueta, Amaya Tavares, Ana M Spyropoulou, Anastasia Solhaug, Anita Olsen, Ann-Karin Vettorazzi, Ariane Mertens, Birgit Zegura, Bojana Streel, Camille Ndiaye, Dieynaba Spilioti, Eliana Dubreil, Estelle Buratti, Franca Maria Crudo, Francesco Eriksen, Gunnar Sundstøl Snapkow, Igor Teixeira, João Paulo Rasinger, Josef D Sanders, Julie Machera, Kyriaki Ivanova, Lada Gaté, Laurent Le Hegarat, Ludovic Novak, Matjaz Smith, Nicola M Tait, Sabrina Fraga, Sónia Hager, Sonja Marko, Doris Braeuning, Albert Louro, Henriqueta Silva, Maria João Dirven, Hubert Dietrich, Jessica Depsipeptides Risk Assessment Humans Animals Mycotoxins Food Contamination Toxicokinetics Enniatins (ENNs) and beauvericin (BEA) are cyclic hexadepsipeptide fungal metabolites which have demonstrated antibiotic, antimycotic, and insecticidal activities. The substantial toxic potentials of these mycotoxins are associated with their ionophoric molecular properties and relatively high lipophilicities. ENNs occur extensively in grain and grain-derived products and are considered a food safety issue by the European Food Safety Authority (EFSA). The tolerable daily intake and maximum levels for ENNs in humans and animals remain unestablished due to key toxicological and toxicokinetic data gaps, preventing full risk assessment. Aiming to find critical data gaps impeding hazard characterization and risk evaluation, this review presents a comprehensive summary of the existing information from in vitro and in vivo studies on toxicokinetic characteristics and cytotoxic, genotoxic, immunotoxic, endocrine, reproductive and developmental effects of the most prevalent ENN analogues (ENN A, A1, B, B1) and BEA. The missing information identified showed that additional studies on ENNs and BEA have to be performed before sufficient data for an in-depth hazard characterisation of these mycotoxins become available. |
| format | Artículo científico |
| id | pubmed_40137953 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Archives of toxicology |
| record_format | pubmed |
| spellingShingle | Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health. Behr, Anne-Cathrin Fæste, Christiane Kruse Azqueta, Amaya Tavares, Ana M Spyropoulou, Anastasia Solhaug, Anita Olsen, Ann-Karin Vettorazzi, Ariane Mertens, Birgit Zegura, Bojana Streel, Camille Ndiaye, Dieynaba Spilioti, Eliana Dubreil, Estelle Buratti, Franca Maria Crudo, Francesco Eriksen, Gunnar Sundstøl Snapkow, Igor Teixeira, João Paulo Rasinger, Josef D Sanders, Julie Machera, Kyriaki Ivanova, Lada Gaté, Laurent Le Hegarat, Ludovic Novak, Matjaz Smith, Nicola M Tait, Sabrina Fraga, Sónia Hager, Sonja Marko, Doris Braeuning, Albert Louro, Henriqueta Silva, Maria João Dirven, Hubert Dietrich, Jessica Depsipeptides Risk Assessment Humans Animals Mycotoxins Food Contamination Toxicokinetics Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health. Behr, Anne-Cathrin Fæste, Christiane Kruse Azqueta, Amaya Tavares, Ana M Spyropoulou, Anastasia Solhaug, Anita Olsen, Ann-Karin Vettorazzi, Ariane Mertens, Birgit Zegura, Bojana Streel, Camille Ndiaye, Dieynaba Spilioti, Eliana Dubreil, Estelle Buratti, Franca Maria Crudo, Francesco Eriksen, Gunnar Sundstøl Snapkow, Igor Teixeira, João Paulo Rasinger, Josef D Sanders, Julie Machera, Kyriaki Ivanova, Lada Gaté, Laurent Le Hegarat, Ludovic Novak, Matjaz Smith, Nicola M Tait, Sabrina Fraga, Sónia Hager, Sonja Marko, Doris Braeuning, Albert Louro, Henriqueta Silva, Maria João Dirven, Hubert Dietrich, Jessica Depsipeptides Risk Assessment Humans Animals Mycotoxins Food Contamination Toxicokinetics Enniatins (ENNs) and beauvericin (BEA) are cyclic hexadepsipeptide fungal metabolites which have demonstrated antibiotic, antimycotic, and insecticidal activities. The substantial toxic potentials of these mycotoxins are associated with their ionophoric molecular properties and relatively high lipophilicities. ENNs occur extensively in grain and grain-derived products and are considered a food safety issue by the European Food Safety Authority (EFSA). The tolerable daily intake and maximum levels for ENNs in humans and animals remain unestablished due to key toxicological and toxicokinetic data gaps, preventing full risk assessment. Aiming to find critical data gaps impeding hazard characterization and risk evaluation, this review presents a comprehensive summary of the existing information from in vitro and in vivo studies on toxicokinetic characteristics and cytotoxic, genotoxic, immunotoxic, endocrine, reproductive and developmental effects of the most prevalent ENN analogues (ENN A, A1, B, B1) and BEA. The missing information identified showed that additional studies on ENNs and BEA have to be performed before sufficient data for an in-depth hazard characterisation of these mycotoxins become available. |
| title | Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health. |
| topic | Depsipeptides Risk Assessment Humans Animals Mycotoxins Food Contamination Toxicokinetics |
| url | https://pubmed.ncbi.nlm.nih.gov/40137953/ |