Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium sp.
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| Autores principales: | , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Journal of natural products
2025
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| Acceso en línea: | |
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| _version_ | 1868266226118033408 |
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| author | Tojo, Shunya Natsume, Noriyuki Niino, Taiki Iwasaki, Arihiro Suenaga, Kiyotake Ohno, Osamu Teruya, Toshiaki |
| author_facet | Tojo, Shunya Natsume, Noriyuki Niino, Taiki Iwasaki, Arihiro Suenaga, Kiyotake Ohno, Osamu Teruya, Toshiaki Tojo, Shunya Natsume, Noriyuki Niino, Taiki Iwasaki, Arihiro Suenaga, Kiyotake Ohno, Osamu Teruya, Toshiaki |
| collection | PubMed - marine biology |
| contents | Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium sp. Tojo, Shunya Natsume, Noriyuki Niino, Taiki Iwasaki, Arihiro Suenaga, Kiyotake Ohno, Osamu Teruya, Toshiaki Nitric Oxide Cyanobacteria Animals Mice Molecular Structure Depsipeptides Lipopolysaccharides Japan Crystallography, X-Ray Marine Biology RAW 264.7 Cells A novel 19-membered cyclic depsipeptide, hedopeptolide (), was isolated from sp., a marine cyanobacterium collected in Okinawa, Japan. Its gross structure was determined by spectroscopic analyses, and the absolute configuration of the chiral centers was determined by single-crystal X-ray diffraction analysis following crystallization. Hedopeptolide () inhibited the lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. |
| format | Artículo científico |
| id | pubmed_40145845 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium sp. Tojo, Shunya Natsume, Noriyuki Niino, Taiki Iwasaki, Arihiro Suenaga, Kiyotake Ohno, Osamu Teruya, Toshiaki Nitric Oxide Cyanobacteria Animals Mice Molecular Structure Depsipeptides Lipopolysaccharides Japan Crystallography, X-Ray Marine Biology RAW 264.7 Cells Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium sp. Tojo, Shunya Natsume, Noriyuki Niino, Taiki Iwasaki, Arihiro Suenaga, Kiyotake Ohno, Osamu Teruya, Toshiaki Nitric Oxide Cyanobacteria Animals Mice Molecular Structure Depsipeptides Lipopolysaccharides Japan Crystallography, X-Ray Marine Biology RAW 264.7 Cells A novel 19-membered cyclic depsipeptide, hedopeptolide (), was isolated from sp., a marine cyanobacterium collected in Okinawa, Japan. Its gross structure was determined by spectroscopic analyses, and the absolute configuration of the chiral centers was determined by single-crystal X-ray diffraction analysis following crystallization. Hedopeptolide () inhibited the lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. |
| title | Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium sp. |
| topic | Nitric Oxide Cyanobacteria Animals Mice Molecular Structure Depsipeptides Lipopolysaccharides Japan Crystallography, X-Ray Marine Biology RAW 264.7 Cells |
| url | https://pubmed.ncbi.nlm.nih.gov/40145845/ |