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| Autores principales: | , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Journal of natural products
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/40145845/ |
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- Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium sp. Tojo, Shunya Natsume, Noriyuki Niino, Taiki Iwasaki, Arihiro Suenaga, Kiyotake Ohno, Osamu Teruya, Toshiaki Nitric Oxide Cyanobacteria Animals Mice Molecular Structure Depsipeptides Lipopolysaccharides Japan Crystallography, X-Ray Marine Biology RAW 264.7 Cells A novel 19-membered cyclic depsipeptide, hedopeptolide (), was isolated from sp., a marine cyanobacterium collected in Okinawa, Japan. Its gross structure was determined by spectroscopic analyses, and the absolute configuration of the chiral centers was determined by single-crystal X-ray diffraction analysis following crystallization. Hedopeptolide () inhibited the lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.