Copertina

Synthesis and biological activity of 1H-pyrrolo[3,2-g]isoquinolines as Haspin kinase inhibitors.

Fuente: PubMed

Salvato in:

Dettagli Bibliografici
Autori principali:	Malosse, Killian, Doula, Marie Ben, Josselin, Béatrice, Robert, Thomas, Anizon, Fabrice, Ruchaud, Sandrine, Giraud, Francis, Moreau, Pascale
Natura:	Artículo científico
Lingua:	en
Pubblicazione:	Bioorganic & medicinal chemistry 2025
Soggetti:	Humans Isoquinolines Protein Kinase Inhibitors Structure-Activity Relationship Intracellular Signaling Peptides and Proteins Cell Survival Cell Line, Tumor Molecular Structure Protein Serine-Threonine Kinases Pyrroles Dose-Response Relationship, Drug
Accesso online:	Acceder al recurso
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi

Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.
di: Bourg, Stéphane, et al.
Pubblicazione: (2026)

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
di: Du, Lin, et al.
Pubblicazione: (2025)

Design, Synthesis, and Evaluation of a Potent and Selective ROCK2 Inhibitor for Atopic Dermatitis Treatment.
di: Mao, Churu, et al.
Pubblicazione: (2026)

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.
di: Cao, Yin, et al.
Pubblicazione: (2025)

Identification of Marine Compounds Inhibiting NF-κBInducing Kinase Through Molecular Docking and Molecular Dynamics Simulations.
di: Yasir, Muhammad, et al.
Pubblicazione: (2024)

Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.
di: Chen, Xiaohui, et al.
Pubblicazione: (2025)

Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition.
di: Tisseur, Lhana, et al.
Pubblicazione: (2025)

Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa.
di: Wicaksono, Danar, et al.
Pubblicazione: (2024)

Computational insights into marine natural products as potential antidiabetic agents targeting the SIK2 protein kinase domain.
di: Heyram, K, et al.
Pubblicazione: (2024)

Activation of prep expression by Tet2 promotes the proliferation of bipotential progenitor cells during liver regeneration.
di: Jia, Kun, et al.
Pubblicazione: (2025)

Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity.
di: Mao, Churu, et al.
Pubblicazione: (2024)

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response.
di: Lu, Long-Feng, et al.
Pubblicazione: (2026)

Primary Cilia-Mediated Hedgehog Signaling Regulates Cell Fate During ER Stress-Induced Life or Death Decisions.
di: Xu, Jia, et al.
Pubblicazione: (2025)

Phosphoethanolamine cytidylyltransferase 2 integrates DAG metabolism and TBK1 activation to regulate antiviral innate immunity.
di: Lai, Wencong, et al.
Pubblicazione: (2026)

Evolutionary analysis and immune-induced expression and mA modification of RIPK1 and RIPK2 in the miiuy croaker.
di: Xing, Qianru, et al.
Pubblicazione: (2025)

BIK1 and ATL31/6 are essential for fucoidan hydrolysate-triggered stomatal closure in Arabidopsis.
di: Chen, Kexin, et al.
Pubblicazione: (2025)

Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress.
di: Ye, Haicheng, et al.
Pubblicazione: (2025)

Amphipathic N-terminal helices drive MLKL-mediated necroptosis through an antimicrobial peptide-like mechanism across evolution.
di: Tian, Xin, et al.
Pubblicazione: (2026)

MEK1/2 inhibition prevents DENV and ZIKV infection via disrupting the cytoskeletal vimentin cage required for viral replication.
di: Huang, Yuhan, et al.
Pubblicazione: (2026)

DHA affects ISKNV-induced autophagy flux via the AMPK/mTOR/ULK1 and BECN1/SQSTM1 axes, limiting viral replication in fish cells.
di: Chen, Kuang-Wen, et al.
Pubblicazione: (2026)

Phosphorylation of peptides by a kinase domain in cyanobactin pathways.
di: Castelo-Branco, Raquel, et al.
Pubblicazione: (2025)

Computational Analysis of Azole Derivatives Targeting the PI3K/AKT/mTOR Pathway With In Vitro Cytotoxicity and Autophagy Evaluation.
di: Regurajan, Rathika, et al.
Pubblicazione: (2026)

Grass carp reovirus VP6 inhibits IFN production by degrading TBK1 through the autophagy pathway.
di: Xu, Xiao, et al.
Pubblicazione: (2025)

Data-Independent Acquisition-Based Quantitative Proteomics, Nontargeted Metabolomics, and Protein-Ligand Interaction Reveal the Mechanism of Baicalin Inhibiting βhemolytic/cytolytic Activities of .
di: Li, Guihua, et al.
Pubblicazione: (2026)

Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches.
di: Saif, Ahmed, et al.
Pubblicazione: (2025)

Sun Exposure and Skin Cancer: A Narrative Review of Risk Factors, Prevention Behaviors, and Emerging Therapeutic Approaches
di: Silva, Luiz Felipe Rodrigues, et al.
Pubblicazione: (2026)

Rewiring mTOR signaling in Alzheimer's disease: emerging mTOR modulators beyond oncology.
di: Lohnes, Benedikt Jakob, et al.
Pubblicazione: (2026)

The novel marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol exhibits anticancer activity by regulating multiple signaling pathways in human glioblastoma cells: Blocking EGF signaling.
di: Yamaguchi, Masayoshi, et al.
Pubblicazione: (2025)

RNF34 negatively regulates innate immunity via ubiquitin-mediated TAK1 degradation in miiuy croaker (Miichthysmiiuy).
di: Dong, Wenjing, et al.
Pubblicazione: (2025)

New Fusarochromanone Derivatives from the Marine Fungus UBOCC-A-117302.
di: Pham, Giang Nam, et al.
Pubblicazione: (2024)

In vitro cytotoxic and pro-apoptotic effects of Chaetoceros socialis ethanolic extract on prostate (LNCap) and glioblastoma (U-87 MG) cells via modulation of AKT/PTEN, mTOR, BAX/BCL2, and Caspase pathways.
di: Asoudeh-Fard, Abbas, et al.
Pubblicazione: (2025)

Hippo-YAP pathway regulates antimicrobial immune response in obscure puffer Takifugu obscurus.
di: Wang, Ruixia, et al.
Pubblicazione: (2025)

A nutrient-responsive AMPK/TBK1 circuit restricts adipocyte catabolism.
di: Wisessaowapak, Churaibhon, et al.
Pubblicazione: (2026)

Grass carp reovirus VP4 manipulates TOLLIP to degrade STING for inhibition of IFN production.
di: Wang, Yang-Yang, et al.
Pubblicazione: (2025)

Particulate matter 2.5 stimulates pyroptosis and necroptosis via the p38 MAPK/Akt/NF-κB signaling pathway in human corneal epithelial cells.
di: Kim, Da Hye, et al.
Pubblicazione: (2025)

Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury.
di: Zhan, Shuai, et al.
Pubblicazione: (2025)

Identification of EEF1A1 as a therapeutic target in TNBC: Anticancer action of a novel Penicillide-derived inhibitor through ribosomal protein regulation.
di: Yu, Jing, et al.
Pubblicazione: (2026)

Regulation of the non-selective Na importer capacity of NRT1.2/NPF4.6/AIT1 by SOS2-mediated phosphorylation in Arabidopsis.
di: Liu, Xiaoxiao, et al.
Pubblicazione: (2025)

Starfish-Derived Extracts Enhance Mitophagy and Suppress Senescence-Associated Markers in Human Dermal Fibroblasts.
di: Lee, Hyun Jung, et al.
Pubblicazione: (2025)

BIT1 as an Effector of EGFR-TKI-induced Apoptosis TLE1 Inhibition in Lung Adenocarcinoma Cells.
di: Dela Cruz, Ma Carmela, et al.
Pubblicazione: (2026)