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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Antibiotics (Basel, Switzerland)
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40149131/ |
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| _version_ | 1868266226114887682 |
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| author | Al Nasr, Ibrahim S Ma, Jingyi Khan, Tariq A Koko, Waleed S Ben Abdelmalek, Imen Schobert, Rainer van de Sande, Wendy Biersack, Bernhard |
| author_facet | Al Nasr, Ibrahim S Ma, Jingyi Khan, Tariq A Koko, Waleed S Ben Abdelmalek, Imen Schobert, Rainer van de Sande, Wendy Biersack, Bernhard Al Nasr, Ibrahim S Ma, Jingyi Khan, Tariq A Koko, Waleed S Ben Abdelmalek, Imen Schobert, Rainer van de Sande, Wendy Biersack, Bernhard |
| collection | PubMed - marine biology |
| contents | Antiparasitic and Antifungal Activities of Cetyl-Maritima, a New -Cetyl-Modified Maritima Derivative. Al Nasr, Ibrahim S Ma, Jingyi Khan, Tariq A Koko, Waleed S Ben Abdelmalek, Imen Schobert, Rainer van de Sande, Wendy Biersack, Bernhard New drugs are urgently needed for the treatment of neglected tropical diseases including leishmaniasis and eumycetoma, as well as globally occurring parasitic diseases such as toxoplasmosis. Fragrances, both natural and synthetic, were shown to be a rich source for the development of new anti-infectives and warrant deeper investigations. Exemplarily, we synthetically optimized the fragrance 4-(4,8-dimethyl-3,7-nonadienyl)-pyridine, a.k.a. Maritima, a pyridine derivative with marine odor. : A new cationic -cetyl-modified derivative of Maritima (dubbed Cetyl-Maritima), obtained by alkylation of Maritima, was tested for its activity against () fungi, as well as against () and () protozoal parasites. : Cetyl-Maritima was found to be more strongly antifungal than the parent Maritima and a known antibiotic cetylpyridinium salt. Cetyl-Maritima also showed a similar activity against parasites and, most notably, exhibited sub-micromolar activity against amastigotes. : The considerable antileishmanial activity of Cetyl-Maritima might lead to the development of a new potent and cost-effective drug candidate for the therapy of leishmaniasis and other infectious diseases caused by kinetoplastid parasites. |
| format | Artículo científico |
| id | pubmed_40149131 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Antibiotics (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | Antiparasitic and Antifungal Activities of Cetyl-Maritima, a New -Cetyl-Modified Maritima Derivative. Al Nasr, Ibrahim S Ma, Jingyi Khan, Tariq A Koko, Waleed S Ben Abdelmalek, Imen Schobert, Rainer van de Sande, Wendy Biersack, Bernhard Antiparasitic and Antifungal Activities of Cetyl-Maritima, a New -Cetyl-Modified Maritima Derivative. Al Nasr, Ibrahim S Ma, Jingyi Khan, Tariq A Koko, Waleed S Ben Abdelmalek, Imen Schobert, Rainer van de Sande, Wendy Biersack, Bernhard New drugs are urgently needed for the treatment of neglected tropical diseases including leishmaniasis and eumycetoma, as well as globally occurring parasitic diseases such as toxoplasmosis. Fragrances, both natural and synthetic, were shown to be a rich source for the development of new anti-infectives and warrant deeper investigations. Exemplarily, we synthetically optimized the fragrance 4-(4,8-dimethyl-3,7-nonadienyl)-pyridine, a.k.a. Maritima, a pyridine derivative with marine odor. : A new cationic -cetyl-modified derivative of Maritima (dubbed Cetyl-Maritima), obtained by alkylation of Maritima, was tested for its activity against () fungi, as well as against () and () protozoal parasites. : Cetyl-Maritima was found to be more strongly antifungal than the parent Maritima and a known antibiotic cetylpyridinium salt. Cetyl-Maritima also showed a similar activity against parasites and, most notably, exhibited sub-micromolar activity against amastigotes. : The considerable antileishmanial activity of Cetyl-Maritima might lead to the development of a new potent and cost-effective drug candidate for the therapy of leishmaniasis and other infectious diseases caused by kinetoplastid parasites. |
| title | Antiparasitic and Antifungal Activities of Cetyl-Maritima, a New -Cetyl-Modified Maritima Derivative. |
| url | https://pubmed.ncbi.nlm.nih.gov/40149131/ |