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| Format: | Artículo científico |
| Sprache: | en |
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2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40149405/ |
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| author | Han, Xiufeng Su, Xue Che, Mingyue Liu, Lanhao Nie, Pin Wang, Su |
| author_facet | Han, Xiufeng Su, Xue Che, Mingyue Liu, Lanhao Nie, Pin Wang, Su Han, Xiufeng Su, Xue Che, Mingyue Liu, Lanhao Nie, Pin Wang, Su |
| collection | PubMed - marine biology |
| contents | Identification and Expression Analyses of Gene Family in Snakehead () Following Infection. Han, Xiufeng Su, Xue Che, Mingyue Liu, Lanhao Nie, Pin Wang, Su Animals Receptors, Interleukin-17 Nocardia Nocardia Infections Interleukin-17 Fish Diseases Fish Proteins Fishes Phylogeny Multigene Family The interleukin 17 (IL-17) family, known for its proinflammatory properties, is important in immune responses against bacterial and fungal infections. To exert its immune function, the IL-17 family typically binds to IL-17 receptor (IL-17R) to facilitate signal transduction. This study identified, cloned and analyzed seven IL-17 and nine IL-17R family members in snakeheads. A duplication event occurred in snakehead and , but bioinformatics analyses indicated that these genes were conserved in both protein domains and evolutionary processes. Tissue distribution analysis revealed that / were widely distributed in the detected tissues, with relatively high expression levels in immune tissues. Upon stimulation, most members were expressed, particularly , , , , , , and , which were significantly upregulated in gill and intestine. These results suggested that and played a crucial role in mucosal immunity against bacterial infection, providing insights into immunoprophylactic strategies for bacterial diseases in aquaculture. |
| format | Artículo científico |
| id | pubmed_40149405 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Genes |
| record_format | pubmed |
| spellingShingle | Identification and Expression Analyses of Gene Family in Snakehead () Following Infection. Han, Xiufeng Su, Xue Che, Mingyue Liu, Lanhao Nie, Pin Wang, Su Animals Receptors, Interleukin-17 Nocardia Nocardia Infections Interleukin-17 Fish Diseases Fish Proteins Fishes Phylogeny Multigene Family Identification and Expression Analyses of Gene Family in Snakehead () Following Infection. Han, Xiufeng Su, Xue Che, Mingyue Liu, Lanhao Nie, Pin Wang, Su Animals Receptors, Interleukin-17 Nocardia Nocardia Infections Interleukin-17 Fish Diseases Fish Proteins Fishes Phylogeny Multigene Family The interleukin 17 (IL-17) family, known for its proinflammatory properties, is important in immune responses against bacterial and fungal infections. To exert its immune function, the IL-17 family typically binds to IL-17 receptor (IL-17R) to facilitate signal transduction. This study identified, cloned and analyzed seven IL-17 and nine IL-17R family members in snakeheads. A duplication event occurred in snakehead and , but bioinformatics analyses indicated that these genes were conserved in both protein domains and evolutionary processes. Tissue distribution analysis revealed that / were widely distributed in the detected tissues, with relatively high expression levels in immune tissues. Upon stimulation, most members were expressed, particularly , , , , , , and , which were significantly upregulated in gill and intestine. These results suggested that and played a crucial role in mucosal immunity against bacterial infection, providing insights into immunoprophylactic strategies for bacterial diseases in aquaculture. |
| title | Identification and Expression Analyses of Gene Family in Snakehead () Following Infection. |
| topic | Animals Receptors, Interleukin-17 Nocardia Nocardia Infections Interleukin-17 Fish Diseases Fish Proteins Fishes Phylogeny Multigene Family |
| url | https://pubmed.ncbi.nlm.nih.gov/40149405/ |