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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Genes
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40149405/ |
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Table of Contents:
- Identification and Expression Analyses of Gene Family in Snakehead () Following Infection. Han, Xiufeng Su, Xue Che, Mingyue Liu, Lanhao Nie, Pin Wang, Su Animals Receptors, Interleukin-17 Nocardia Nocardia Infections Interleukin-17 Fish Diseases Fish Proteins Fishes Phylogeny Multigene Family The interleukin 17 (IL-17) family, known for its proinflammatory properties, is important in immune responses against bacterial and fungal infections. To exert its immune function, the IL-17 family typically binds to IL-17 receptor (IL-17R) to facilitate signal transduction. This study identified, cloned and analyzed seven IL-17 and nine IL-17R family members in snakeheads. A duplication event occurred in snakehead and , but bioinformatics analyses indicated that these genes were conserved in both protein domains and evolutionary processes. Tissue distribution analysis revealed that / were widely distributed in the detected tissues, with relatively high expression levels in immune tissues. Upon stimulation, most members were expressed, particularly , , , , , , and , which were significantly upregulated in gill and intestine. These results suggested that and played a crucial role in mucosal immunity against bacterial infection, providing insights into immunoprophylactic strategies for bacterial diseases in aquaculture.