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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
International journal of biological macromolecules
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40154708/ |
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| _version_ | 1868266226109644800 |
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| author | Han, Xiangru Tian, Liguang Chen, Qiuhong Wang, Linqing Mi, Yingqi Li, Qing Guo, Zhanyong Dong, Fang |
| author_facet | Han, Xiangru Tian, Liguang Chen, Qiuhong Wang, Linqing Mi, Yingqi Li, Qing Guo, Zhanyong Dong, Fang Han, Xiangru Tian, Liguang Chen, Qiuhong Wang, Linqing Mi, Yingqi Li, Qing Guo, Zhanyong Dong, Fang |
| collection | PubMed - marine biology |
| contents | Preparation of novel thiolated chitosan with significant antioxidant activity. Han, Xiangru Tian, Liguang Chen, Qiuhong Wang, Linqing Mi, Yingqi Li, Qing Guo, Zhanyong Dong, Fang Chitosan Antioxidants Sulfhydryl Compounds Free Radical Scavengers Picrates Solubility Biphenyl Compounds Hydroxyl Radical Superoxides Humans The aim of this study was to synthesize thiolated chitosan derivative and evaluated its antioxidant activity. Thiol groups were introduced into chitosan and hydroxypropyl trimethylammonium chloride chitosan quaternary ammonium salt (HACC) by microwave reaction, respectively. At the same time, a series of compounds containing thiol groups were introduced at the amino site. The structure of the chitosan derivatives was identified by FTIR and H NMR. The thiol groups content, thermal stability, water solubility and cytotoxicity of the chitosan derivative were evaluated. The antioxidant activity of chitosan derivatives was evaluated using superoxide anion radical scavenging activity assay, DPPH radical scavenging activity assay, hydroxyl radical scavenging activity assay and reducing power assay. The results showed that the thiolated chitosan derivatives obtained in this study possessed excellent antioxidant activity, which provides a new idea for the further study of chitosan antioxidants. |
| format | Artículo científico |
| id | pubmed_40154708 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | International journal of biological macromolecules |
| record_format | pubmed |
| spellingShingle | Preparation of novel thiolated chitosan with significant antioxidant activity. Han, Xiangru Tian, Liguang Chen, Qiuhong Wang, Linqing Mi, Yingqi Li, Qing Guo, Zhanyong Dong, Fang Chitosan Antioxidants Sulfhydryl Compounds Free Radical Scavengers Picrates Solubility Biphenyl Compounds Hydroxyl Radical Superoxides Humans Preparation of novel thiolated chitosan with significant antioxidant activity. Han, Xiangru Tian, Liguang Chen, Qiuhong Wang, Linqing Mi, Yingqi Li, Qing Guo, Zhanyong Dong, Fang Chitosan Antioxidants Sulfhydryl Compounds Free Radical Scavengers Picrates Solubility Biphenyl Compounds Hydroxyl Radical Superoxides Humans The aim of this study was to synthesize thiolated chitosan derivative and evaluated its antioxidant activity. Thiol groups were introduced into chitosan and hydroxypropyl trimethylammonium chloride chitosan quaternary ammonium salt (HACC) by microwave reaction, respectively. At the same time, a series of compounds containing thiol groups were introduced at the amino site. The structure of the chitosan derivatives was identified by FTIR and H NMR. The thiol groups content, thermal stability, water solubility and cytotoxicity of the chitosan derivative were evaluated. The antioxidant activity of chitosan derivatives was evaluated using superoxide anion radical scavenging activity assay, DPPH radical scavenging activity assay, hydroxyl radical scavenging activity assay and reducing power assay. The results showed that the thiolated chitosan derivatives obtained in this study possessed excellent antioxidant activity, which provides a new idea for the further study of chitosan antioxidants. |
| title | Preparation of novel thiolated chitosan with significant antioxidant activity. |
| topic | Chitosan Antioxidants Sulfhydryl Compounds Free Radical Scavengers Picrates Solubility Biphenyl Compounds Hydroxyl Radical Superoxides Humans |
| url | https://pubmed.ncbi.nlm.nih.gov/40154708/ |