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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40156853/ |
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Table of Contents:
- Cinerols L-R, Anti-inflammatory Meroterpenoids from the Marine Sponge . Shang, Ru-Yi Sun, Fan Luo, Xiang-Chao Cheng, Bao-Hui Li, Jia-Xin Hu, Tian-Yong Xie, Dong-Dong Capon, Robert J Lin, Hou-Wen Jiao, Wei-Hua Animals Mice Dysidea Tumor Necrosis Factor-alpha Anti-Inflammatory Agents Molecular Structure Macrophages Lipopolysaccharides Terpenes NF-kappa B RAW 264.7 Cells Sesquiterpenes Dinoprostone Porifera Cyclooxygenase 2 China Hydroquinones Marine Biology Interleukin-6 Inhibitors Seven new sesquiterpene hydroquinone/quinone (SQ) meroterpenoids, cinerols L-R (-), along with four known analogues (-), were identified from a marine sponge, , collected from the shore of the Xisha Islands in the South China Sea. The structures of - were established by the analysis of NMR, high-resolution MS, and comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Cinerol L () is particularly noteworthy, as it features a 5-pyrrolo[1,2a]-benzimidazole moiety modified by an ethyl sulfonate, while cinerols N () and O () possess a unique acetyl-substituted hydroquinone moiety. Cinerols L-R (-) were evaluated for their inhibitory activity against inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and prostaglandin E2 (PGE) with IC values of 5-20 μM in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages. Furthermore, the potent inhibitory activity on inflammatory cytokines of prompted us to evaluate its effect on the nuclear factor-κB (NF-κB)/mitogen-activated protein kinase (MAPK) signaling pathway, a critical pathway that contributes to the inflammatory responses. Cinerol O () was unveiled to inhibit cyclooxygenase-2 (COX-2) expression and the production of inflammatory cytokines via suppressing the expression of NF-κB and MAPKs in LPS-induced RAW 264.7 macrophages.