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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Natural product research
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40164128/ |
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| _version_ | 1868266223134834688 |
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| author | Liu, Xue Zhao, Wen Gai, Xinyue Zhang, Miansong Cui, Tingting Du, Hongfang Jia, Airong |
| author_facet | Liu, Xue Zhao, Wen Gai, Xinyue Zhang, Miansong Cui, Tingting Du, Hongfang Jia, Airong Liu, Xue Zhao, Wen Gai, Xinyue Zhang, Miansong Cui, Tingting Du, Hongfang Jia, Airong |
| collection | PubMed - marine biology |
| contents | Anticoagulant and angiotensin-converting enzyme inhibitory activities of a fucoidan from and its low molecular weight fragments prepared by acid degradation. Liu, Xue Zhao, Wen Gai, Xinyue Zhang, Miansong Cui, Tingting Du, Hongfang Jia, Airong Sargassum Polysaccharides Angiotensin-Converting Enzyme Inhibitors Molecular Weight Anticoagulants Partial Thromboplastin Time Thrombin Humans A purified fucoidan SF (348 kDa) was isolated from Six low molecular weight fragments SFs (75-8.1 kDa) were prepared by acid degradation from SF. Anticoagulant properties of SF and SFs were evaluated. SF and SFs with 75-17 kDa had better anticoagulant activities with the activated partial thromboplastin time (APTT) greater than 120 s at 200 μg/mL. The decrease in the molecular weight caused a decrease in anticoagulant activity, and a slight decrease almost resulted in loss of anticoagulant activity when below 17 kDa (APTT < 59 s). Angiotensin-converting-enzyme (ACE)-inhibitory activities were also detected. Only when the molecular weight dropped to a certain extent (8.1 kDa), the fucoidan showed ACE-inhibitory activity (IC=2.16 mg/mL). Structure analysis indicated the main change of SFs was a reduction in molecular weight. Thus molecular weight is an essential factor affecting the bioactivities. Longer chains were essential to complete thrombin inhibition, whereas ACE-inhibitory activity required shorter ones. |
| format | Artículo científico |
| id | pubmed_40164128 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Natural product research |
| record_format | pubmed |
| spellingShingle | Anticoagulant and angiotensin-converting enzyme inhibitory activities of a fucoidan from and its low molecular weight fragments prepared by acid degradation. Liu, Xue Zhao, Wen Gai, Xinyue Zhang, Miansong Cui, Tingting Du, Hongfang Jia, Airong Sargassum Polysaccharides Angiotensin-Converting Enzyme Inhibitors Molecular Weight Anticoagulants Partial Thromboplastin Time Thrombin Humans Anticoagulant and angiotensin-converting enzyme inhibitory activities of a fucoidan from and its low molecular weight fragments prepared by acid degradation. Liu, Xue Zhao, Wen Gai, Xinyue Zhang, Miansong Cui, Tingting Du, Hongfang Jia, Airong Sargassum Polysaccharides Angiotensin-Converting Enzyme Inhibitors Molecular Weight Anticoagulants Partial Thromboplastin Time Thrombin Humans A purified fucoidan SF (348 kDa) was isolated from Six low molecular weight fragments SFs (75-8.1 kDa) were prepared by acid degradation from SF. Anticoagulant properties of SF and SFs were evaluated. SF and SFs with 75-17 kDa had better anticoagulant activities with the activated partial thromboplastin time (APTT) greater than 120 s at 200 μg/mL. The decrease in the molecular weight caused a decrease in anticoagulant activity, and a slight decrease almost resulted in loss of anticoagulant activity when below 17 kDa (APTT < 59 s). Angiotensin-converting-enzyme (ACE)-inhibitory activities were also detected. Only when the molecular weight dropped to a certain extent (8.1 kDa), the fucoidan showed ACE-inhibitory activity (IC=2.16 mg/mL). Structure analysis indicated the main change of SFs was a reduction in molecular weight. Thus molecular weight is an essential factor affecting the bioactivities. Longer chains were essential to complete thrombin inhibition, whereas ACE-inhibitory activity required shorter ones. |
| title | Anticoagulant and angiotensin-converting enzyme inhibitory activities of a fucoidan from and its low molecular weight fragments prepared by acid degradation. |
| topic | Sargassum Polysaccharides Angiotensin-Converting Enzyme Inhibitors Molecular Weight Anticoagulants Partial Thromboplastin Time Thrombin Humans |
| url | https://pubmed.ncbi.nlm.nih.gov/40164128/ |