Sealgamide: An Antitrypanosomal Lipopeptide Isolated from a Marine sp. Cyanobacterium.
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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Journal of natural products
2025
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| author | Wakai, Kazuki Kurisawa, Naoaki Umeda, Kairi Jeelani, Ghulam Agusta, Adnan Luthfi Nozaki, Tomoyoshi Suenaga, Kiyotake |
| author_facet | Wakai, Kazuki Kurisawa, Naoaki Umeda, Kairi Jeelani, Ghulam Agusta, Adnan Luthfi Nozaki, Tomoyoshi Suenaga, Kiyotake Wakai, Kazuki Kurisawa, Naoaki Umeda, Kairi Jeelani, Ghulam Agusta, Adnan Luthfi Nozaki, Tomoyoshi Suenaga, Kiyotake |
| collection | PubMed - marine biology |
| contents | Sealgamide: An Antitrypanosomal Lipopeptide Isolated from a Marine sp. Cyanobacterium. Wakai, Kazuki Kurisawa, Naoaki Umeda, Kairi Jeelani, Ghulam Agusta, Adnan Luthfi Nozaki, Tomoyoshi Suenaga, Kiyotake Lipopeptides Trypanosoma brucei rhodesiense Cyanobacteria Molecular Structure Trypanocidal Agents Plasmodium falciparum Marine Biology Antimalarials Animals Sealgamide (), a new antitrypanosomal lipopeptide, was isolated from a marine sp. cyanobacterium. Elucidation of its structure was challenging due to signal overlap caused by conspicuous rotamers but was ultimately achieved through partial hydrolysis and subsequent spectroscopic analyses. Sealgamide () exhibited moderate antitrypanosomal activity against (IC 2.9 μM) while showing no antimalarial activity (IC > 25 μM) or cytotoxicity (IC > 30 μM). Furthermore, we discovered that an artificial C-terminal methyl ester analogue () exhibited notably enhanced antiparasitic activity. |
| format | Artículo científico |
| id | pubmed_40165463 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | Sealgamide: An Antitrypanosomal Lipopeptide Isolated from a Marine sp. Cyanobacterium. Wakai, Kazuki Kurisawa, Naoaki Umeda, Kairi Jeelani, Ghulam Agusta, Adnan Luthfi Nozaki, Tomoyoshi Suenaga, Kiyotake Lipopeptides Trypanosoma brucei rhodesiense Cyanobacteria Molecular Structure Trypanocidal Agents Plasmodium falciparum Marine Biology Antimalarials Animals Sealgamide: An Antitrypanosomal Lipopeptide Isolated from a Marine sp. Cyanobacterium. Wakai, Kazuki Kurisawa, Naoaki Umeda, Kairi Jeelani, Ghulam Agusta, Adnan Luthfi Nozaki, Tomoyoshi Suenaga, Kiyotake Lipopeptides Trypanosoma brucei rhodesiense Cyanobacteria Molecular Structure Trypanocidal Agents Plasmodium falciparum Marine Biology Antimalarials Animals Sealgamide (), a new antitrypanosomal lipopeptide, was isolated from a marine sp. cyanobacterium. Elucidation of its structure was challenging due to signal overlap caused by conspicuous rotamers but was ultimately achieved through partial hydrolysis and subsequent spectroscopic analyses. Sealgamide () exhibited moderate antitrypanosomal activity against (IC 2.9 μM) while showing no antimalarial activity (IC > 25 μM) or cytotoxicity (IC > 30 μM). Furthermore, we discovered that an artificial C-terminal methyl ester analogue () exhibited notably enhanced antiparasitic activity. |
| title | Sealgamide: An Antitrypanosomal Lipopeptide Isolated from a Marine sp. Cyanobacterium. |
| topic | Lipopeptides Trypanosoma brucei rhodesiense Cyanobacteria Molecular Structure Trypanocidal Agents Plasmodium falciparum Marine Biology Antimalarials Animals |
| url | https://pubmed.ncbi.nlm.nih.gov/40165463/ |