Adaptive genomic plasticity in large-genome, broad-host-range vibrio phages.
Fuente:
PubMed
Salvato in:
| Autori principali: | , , , , , , , , , , , , , , , , |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
The ISME journal
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1868266221014614017 |
|---|---|
| author | Bernard, Charles Labreuche, Yannick Diarra, Carine Daszkowski, Pauline Cahier, Karine Goudenège, David Lamarche, Martin G Whitfield, Gregory B Lang, Manon Valencia, Jeffrey Groseille, Justine Piel, Damien Lee, Yan-Jiun Weigele, Peter Brun, Yves V Rocha, Eduardo P C Le Roux, Frédérique |
| author_facet | Bernard, Charles Labreuche, Yannick Diarra, Carine Daszkowski, Pauline Cahier, Karine Goudenège, David Lamarche, Martin G Whitfield, Gregory B Lang, Manon Valencia, Jeffrey Groseille, Justine Piel, Damien Lee, Yan-Jiun Weigele, Peter Brun, Yves V Rocha, Eduardo P C Le Roux, Frédérique Bernard, Charles Labreuche, Yannick Diarra, Carine Daszkowski, Pauline Cahier, Karine Goudenège, David Lamarche, Martin G Whitfield, Gregory B Lang, Manon Valencia, Jeffrey Groseille, Justine Piel, Damien Lee, Yan-Jiun Weigele, Peter Brun, Yves V Rocha, Eduardo P C Le Roux, Frédérique |
| collection | PubMed - marine biology |
| contents | Adaptive genomic plasticity in large-genome, broad-host-range vibrio phages. Bernard, Charles Labreuche, Yannick Diarra, Carine Daszkowski, Pauline Cahier, Karine Goudenège, David Lamarche, Martin G Whitfield, Gregory B Lang, Manon Valencia, Jeffrey Groseille, Justine Piel, Damien Lee, Yan-Jiun Weigele, Peter Brun, Yves V Rocha, Eduardo P C Le Roux, Frédérique Genome, Viral Host Specificity Bacteriophages Vibrio Animals Phylogeny Crassostrea Seawater Recombination, Genetic The host range of a bacteriophage-the diversity of hosts it can infect-is central to understanding phage ecology and applications. Whereas most well-characterized phages have narrow host ranges, broad-host-range phages represent an intriguing component of marine ecosystems. The genetic and evolutionary mechanisms driving their generalism remain poorly understood. In this study, we analyzed Schizotequatroviruses and their Vibrio crassostreae hosts, collected from an oyster farm. Schizotequatroviruses exhibit broad host ranges, large genomes (~252 kbp) encoding 26 transfer ribonucleic acids, and conserved genomic organization interspersed with recombination hotspots. These recombination events, particularly in regions encoding receptor-binding proteins and antidefense systems, highlight their adaptability to host resistance. Some lineages demonstrated the ability of receptor-switching between OmpK and LamB. Despite their broad host range, Schizotequatroviruses were rare in the environment. Their scarcity could not be attributed to burst size, which was comparable to other phages in vitro, but may result from ecological constraints or fitness trade-offs, such as their preference for targeting generalist vibrios in seawater rather than the patho-phylotypes selected in oyster farms. Our findings clarify the genetic and ecological variables shaping Schizotequatrovirus generalism and provide a foundation for future phage applications in aquaculture and beyond. |
| format | Artículo científico |
| id | pubmed_40184633 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | The ISME journal |
| record_format | pubmed |
| spellingShingle | Adaptive genomic plasticity in large-genome, broad-host-range vibrio phages. Bernard, Charles Labreuche, Yannick Diarra, Carine Daszkowski, Pauline Cahier, Karine Goudenège, David Lamarche, Martin G Whitfield, Gregory B Lang, Manon Valencia, Jeffrey Groseille, Justine Piel, Damien Lee, Yan-Jiun Weigele, Peter Brun, Yves V Rocha, Eduardo P C Le Roux, Frédérique Genome, Viral Host Specificity Bacteriophages Vibrio Animals Phylogeny Crassostrea Seawater Recombination, Genetic Adaptive genomic plasticity in large-genome, broad-host-range vibrio phages. Bernard, Charles Labreuche, Yannick Diarra, Carine Daszkowski, Pauline Cahier, Karine Goudenège, David Lamarche, Martin G Whitfield, Gregory B Lang, Manon Valencia, Jeffrey Groseille, Justine Piel, Damien Lee, Yan-Jiun Weigele, Peter Brun, Yves V Rocha, Eduardo P C Le Roux, Frédérique Genome, Viral Host Specificity Bacteriophages Vibrio Animals Phylogeny Crassostrea Seawater Recombination, Genetic The host range of a bacteriophage-the diversity of hosts it can infect-is central to understanding phage ecology and applications. Whereas most well-characterized phages have narrow host ranges, broad-host-range phages represent an intriguing component of marine ecosystems. The genetic and evolutionary mechanisms driving their generalism remain poorly understood. In this study, we analyzed Schizotequatroviruses and their Vibrio crassostreae hosts, collected from an oyster farm. Schizotequatroviruses exhibit broad host ranges, large genomes (~252 kbp) encoding 26 transfer ribonucleic acids, and conserved genomic organization interspersed with recombination hotspots. These recombination events, particularly in regions encoding receptor-binding proteins and antidefense systems, highlight their adaptability to host resistance. Some lineages demonstrated the ability of receptor-switching between OmpK and LamB. Despite their broad host range, Schizotequatroviruses were rare in the environment. Their scarcity could not be attributed to burst size, which was comparable to other phages in vitro, but may result from ecological constraints or fitness trade-offs, such as their preference for targeting generalist vibrios in seawater rather than the patho-phylotypes selected in oyster farms. Our findings clarify the genetic and ecological variables shaping Schizotequatrovirus generalism and provide a foundation for future phage applications in aquaculture and beyond. |
| title | Adaptive genomic plasticity in large-genome, broad-host-range vibrio phages. |
| topic | Genome, Viral Host Specificity Bacteriophages Vibrio Animals Phylogeny Crassostrea Seawater Recombination, Genetic |
| url | https://pubmed.ncbi.nlm.nih.gov/40184633/ |