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| Format: | Artículo científico |
| Sprache: | en |
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Chemistry & biodiversity
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40193191/ |
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| _version_ | 1868266221002031104 |
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| author | Dong, Guan-Hai Li, Xiao-Ming Wang, Ying Wang, Bin-Gui Meng, Ling-Hong |
| author_facet | Dong, Guan-Hai Li, Xiao-Ming Wang, Ying Wang, Bin-Gui Meng, Ling-Hong Dong, Guan-Hai Li, Xiao-Ming Wang, Ying Wang, Bin-Gui Meng, Ling-Hong |
| collection | PubMed - marine biology |
| contents | Talarodride I, an Unusual Penta-Nor-Nonadride and Other Derivatives Characterized From the Deep-Sea Seamount-sourced Endozoic Talaromyces scorteus AS-242. Dong, Guan-Hai Li, Xiao-Ming Wang, Ying Wang, Bin-Gui Meng, Ling-Hong Talaromyces Anti-Bacterial Agents Microbial Sensitivity Tests Escherichia coli Molecular Structure Humans Density Functional Theory Structure-Activity Relationship Talarodride I (1), the first representative of penta-nor-nonadride derivative having a caged bicyclo[4.3.1]deca-2,6-diene core skeleton with an aldehyde group at C-15, together with a new congener talarodride J (2) and five known secondary metabolites (3-7), were isolated and identified from the Magellan seamount-sourced sea-anemone endozoic fungus Talaromyces scorteus AS-242. Their structures were assigned by nuclear magnetic resonance and mass spectroscopic data analysis and time-dependent density functional theory electronic circular dichroism calculations. In the antibacterial assays compounds 1-5 displayed activities against a broad spectrum of human- and aquatic pathogens, with compounds 1 and 2 showing potent inhibitory effects against Escherichia coli and Aeromonas hydrophilia (minimum inhibitory concentration values 1-4 µg/mL). |
| format | Artículo científico |
| id | pubmed_40193191 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Chemistry & biodiversity |
| record_format | pubmed |
| spellingShingle | Talarodride I, an Unusual Penta-Nor-Nonadride and Other Derivatives Characterized From the Deep-Sea Seamount-sourced Endozoic Talaromyces scorteus AS-242. Dong, Guan-Hai Li, Xiao-Ming Wang, Ying Wang, Bin-Gui Meng, Ling-Hong Talaromyces Anti-Bacterial Agents Microbial Sensitivity Tests Escherichia coli Molecular Structure Humans Density Functional Theory Structure-Activity Relationship Talarodride I, an Unusual Penta-Nor-Nonadride and Other Derivatives Characterized From the Deep-Sea Seamount-sourced Endozoic Talaromyces scorteus AS-242. Dong, Guan-Hai Li, Xiao-Ming Wang, Ying Wang, Bin-Gui Meng, Ling-Hong Talaromyces Anti-Bacterial Agents Microbial Sensitivity Tests Escherichia coli Molecular Structure Humans Density Functional Theory Structure-Activity Relationship Talarodride I (1), the first representative of penta-nor-nonadride derivative having a caged bicyclo[4.3.1]deca-2,6-diene core skeleton with an aldehyde group at C-15, together with a new congener talarodride J (2) and five known secondary metabolites (3-7), were isolated and identified from the Magellan seamount-sourced sea-anemone endozoic fungus Talaromyces scorteus AS-242. Their structures were assigned by nuclear magnetic resonance and mass spectroscopic data analysis and time-dependent density functional theory electronic circular dichroism calculations. In the antibacterial assays compounds 1-5 displayed activities against a broad spectrum of human- and aquatic pathogens, with compounds 1 and 2 showing potent inhibitory effects against Escherichia coli and Aeromonas hydrophilia (minimum inhibitory concentration values 1-4 µg/mL). |
| title | Talarodride I, an Unusual Penta-Nor-Nonadride and Other Derivatives Characterized From the Deep-Sea Seamount-sourced Endozoic Talaromyces scorteus AS-242. |
| topic | Talaromyces Anti-Bacterial Agents Microbial Sensitivity Tests Escherichia coli Molecular Structure Humans Density Functional Theory Structure-Activity Relationship |
| url | https://pubmed.ncbi.nlm.nih.gov/40193191/ |