Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution.
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PubMed
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Cell
2025
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| Acceso en línea: | |
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| author | Wu, Zhisheng Wang, Yiheng Chen, Wei-Wei Sun, Hua Chen, Xiaoyan Li, Xiaobo Wang, Zeshuai Liang, Weizheng Wang, Shuang-Yin Luan, Xuemei Li, Yijiang Huang, Shangjin Liang, Yuteng Zhang, Jiaqi Chen, Zhou-Feng Wang, Guanlin Gao, Yun Liu, Yanan Wang, Jun Liu, Zhen Shi, Peng Liu, Cirong Lv, Longbao Hou, Anli Wu, Chenglin Yao, Chen Hong, Zexuan Dai, Ji Lu, Zhonghua Pan, Fan Chen, Xin Kettenmann, Helmut Amit, Ido Speakman, John R Chen, Yun Ginhoux, Florent Cui, Rongfeng Huang, Tianwen Li, Hanjie |
| author_facet | Wu, Zhisheng Wang, Yiheng Chen, Wei-Wei Sun, Hua Chen, Xiaoyan Li, Xiaobo Wang, Zeshuai Liang, Weizheng Wang, Shuang-Yin Luan, Xuemei Li, Yijiang Huang, Shangjin Liang, Yuteng Zhang, Jiaqi Chen, Zhou-Feng Wang, Guanlin Gao, Yun Liu, Yanan Wang, Jun Liu, Zhen Shi, Peng Liu, Cirong Lv, Longbao Hou, Anli Wu, Chenglin Yao, Chen Hong, Zexuan Dai, Ji Lu, Zhonghua Pan, Fan Chen, Xin Kettenmann, Helmut Amit, Ido Speakman, John R Chen, Yun Ginhoux, Florent Cui, Rongfeng Huang, Tianwen Li, Hanjie Wu, Zhisheng Wang, Yiheng Chen, Wei-Wei Sun, Hua Chen, Xiaoyan Li, Xiaobo Wang, Zeshuai Liang, Weizheng Wang, Shuang-Yin Luan, Xuemei Li, Yijiang Huang, Shangjin Liang, Yuteng Zhang, Jiaqi Chen, Zhou-Feng Wang, Guanlin Gao, Yun Liu, Yanan Wang, Jun Liu, Zhen Shi, Peng Liu, Cirong Lv, Longbao Hou, Anli Wu, Chenglin Yao, Chen Hong, Zexuan Dai, Ji Lu, Zhonghua Pan, Fan Chen, Xin Kettenmann, Helmut Amit, Ido Speakman, John R Chen, Yun Ginhoux, Florent Cui, Rongfeng Huang, Tianwen Li, Hanjie |
| collection | PubMed - marine biology |
| contents | Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution. Wu, Zhisheng Wang, Yiheng Chen, Wei-Wei Sun, Hua Chen, Xiaoyan Li, Xiaobo Wang, Zeshuai Liang, Weizheng Wang, Shuang-Yin Luan, Xuemei Li, Yijiang Huang, Shangjin Liang, Yuteng Zhang, Jiaqi Chen, Zhou-Feng Wang, Guanlin Gao, Yun Liu, Yanan Wang, Jun Liu, Zhen Shi, Peng Liu, Cirong Lv, Longbao Hou, Anli Wu, Chenglin Yao, Chen Hong, Zexuan Dai, Ji Lu, Zhonghua Pan, Fan Chen, Xin Kettenmann, Helmut Amit, Ido Speakman, John R Chen, Yun Ginhoux, Florent Cui, Rongfeng Huang, Tianwen Li, Hanjie Animals Microglia Neurons Peripheral Nervous System Biological Evolution Phylogeny Mice Cell Size Axons Central Nervous System Vertebrates Macrophages Microglia, essential in the central nervous system (CNS), were historically considered absent from the peripheral nervous system (PNS). Here, we show a PNS-resident macrophage population that shares transcriptomic and epigenetic profiles as well as an ontogenetic trajectory with CNS microglia. This population (termed PNS microglia-like cells) enwraps the neuronal soma inside the satellite glial cell envelope, preferentially associates with larger neurons during PNS development, and is required for neuronal functions by regulating soma enlargement and axon growth. A phylogenetic survey of 24 vertebrates revealed an early origin of PNS microglia-like cells, whose presence is correlated with neuronal soma size (and body size) rather than evolutionary distance. Consistent with their requirement for soma enlargement, PNS microglia-like cells are maintained in vertebrates with large peripheral neuronal soma but absent when neurons evolve to have smaller soma. Our study thus reveals a PNS counterpart of CNS microglia that regulates neuronal soma size during both evolution and ontogeny. |
| format | Artículo científico |
| id | pubmed_40199320 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Cell |
| record_format | pubmed |
| spellingShingle | Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution. Wu, Zhisheng Wang, Yiheng Chen, Wei-Wei Sun, Hua Chen, Xiaoyan Li, Xiaobo Wang, Zeshuai Liang, Weizheng Wang, Shuang-Yin Luan, Xuemei Li, Yijiang Huang, Shangjin Liang, Yuteng Zhang, Jiaqi Chen, Zhou-Feng Wang, Guanlin Gao, Yun Liu, Yanan Wang, Jun Liu, Zhen Shi, Peng Liu, Cirong Lv, Longbao Hou, Anli Wu, Chenglin Yao, Chen Hong, Zexuan Dai, Ji Lu, Zhonghua Pan, Fan Chen, Xin Kettenmann, Helmut Amit, Ido Speakman, John R Chen, Yun Ginhoux, Florent Cui, Rongfeng Huang, Tianwen Li, Hanjie Animals Microglia Neurons Peripheral Nervous System Biological Evolution Phylogeny Mice Cell Size Axons Central Nervous System Vertebrates Macrophages Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution. Wu, Zhisheng Wang, Yiheng Chen, Wei-Wei Sun, Hua Chen, Xiaoyan Li, Xiaobo Wang, Zeshuai Liang, Weizheng Wang, Shuang-Yin Luan, Xuemei Li, Yijiang Huang, Shangjin Liang, Yuteng Zhang, Jiaqi Chen, Zhou-Feng Wang, Guanlin Gao, Yun Liu, Yanan Wang, Jun Liu, Zhen Shi, Peng Liu, Cirong Lv, Longbao Hou, Anli Wu, Chenglin Yao, Chen Hong, Zexuan Dai, Ji Lu, Zhonghua Pan, Fan Chen, Xin Kettenmann, Helmut Amit, Ido Speakman, John R Chen, Yun Ginhoux, Florent Cui, Rongfeng Huang, Tianwen Li, Hanjie Animals Microglia Neurons Peripheral Nervous System Biological Evolution Phylogeny Mice Cell Size Axons Central Nervous System Vertebrates Macrophages Microglia, essential in the central nervous system (CNS), were historically considered absent from the peripheral nervous system (PNS). Here, we show a PNS-resident macrophage population that shares transcriptomic and epigenetic profiles as well as an ontogenetic trajectory with CNS microglia. This population (termed PNS microglia-like cells) enwraps the neuronal soma inside the satellite glial cell envelope, preferentially associates with larger neurons during PNS development, and is required for neuronal functions by regulating soma enlargement and axon growth. A phylogenetic survey of 24 vertebrates revealed an early origin of PNS microglia-like cells, whose presence is correlated with neuronal soma size (and body size) rather than evolutionary distance. Consistent with their requirement for soma enlargement, PNS microglia-like cells are maintained in vertebrates with large peripheral neuronal soma but absent when neurons evolve to have smaller soma. Our study thus reveals a PNS counterpart of CNS microglia that regulates neuronal soma size during both evolution and ontogeny. |
| title | Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution. |
| topic | Animals Microglia Neurons Peripheral Nervous System Biological Evolution Phylogeny Mice Cell Size Axons Central Nervous System Vertebrates Macrophages |
| url | https://pubmed.ncbi.nlm.nih.gov/40199320/ |