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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Science (New York, N.Y.)
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/40208960/ |
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| _version_ | 1868266216507834368 |
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| author | Erazo-Garcia, Maria P Sheyn, Uri Barth, Zachary K Craig, Rory J Wessman, Petronella Jivaji, Abdeali M Ray, W Keith Svensson-Coelho, Maria Cornwallis, Charlie K Rengefors, Karin Brussaard, Corina P D Moniruzzaman, Mohammad Aylward, Frank O |
| author_facet | Erazo-Garcia, Maria P Sheyn, Uri Barth, Zachary K Craig, Rory J Wessman, Petronella Jivaji, Abdeali M Ray, W Keith Svensson-Coelho, Maria Cornwallis, Charlie K Rengefors, Karin Brussaard, Corina P D Moniruzzaman, Mohammad Aylward, Frank O Erazo-Garcia, Maria P Sheyn, Uri Barth, Zachary K Craig, Rory J Wessman, Petronella Jivaji, Abdeali M Ray, W Keith Svensson-Coelho, Maria Cornwallis, Charlie K Rengefors, Karin Brussaard, Corina P D Moniruzzaman, Mohammad Aylward, Frank O |
| collection | PubMed - marine biology |
| contents | Cryptic infection of a giant virus in a unicellular green alga. Erazo-Garcia, Maria P Sheyn, Uri Barth, Zachary K Craig, Rory J Wessman, Petronella Jivaji, Abdeali M Ray, W Keith Svensson-Coelho, Maria Cornwallis, Charlie K Rengefors, Karin Brussaard, Corina P D Moniruzzaman, Mohammad Aylward, Frank O Chlamydomonas reinhardtii Genome, Viral Giant Viruses Virus Latency DNA Transposable Elements Virus Integration Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. In this work, we describe a 617-kilo-base pairs integrated giant viral element in the model green alga . We resolved the integrated viral genome using long-read sequencing, identified a putative polintovirus-like integrase, and show that viral particles accumulate primarily during the stationary growth phase. A diverse array of viral-encoded selfish genetic elements is expressed during viral activity, including several Fanzor nuclease-encoding transposable elements. In addition, we show that field isolates of spp. harbor signatures of endogenous giant viruses related to the virus that exhibit similar infection dynamics, suggesting that giant virus latency is prevalent in natural host communities. Our work describes an unusually large temperate virus of a unicellular eukaryote, substantially expanding the scope of cryptic viral infections in the virosphere. |
| format | Artículo científico |
| id | pubmed_40208960 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Science (New York, N.Y.) |
| record_format | pubmed |
| spellingShingle | Cryptic infection of a giant virus in a unicellular green alga. Erazo-Garcia, Maria P Sheyn, Uri Barth, Zachary K Craig, Rory J Wessman, Petronella Jivaji, Abdeali M Ray, W Keith Svensson-Coelho, Maria Cornwallis, Charlie K Rengefors, Karin Brussaard, Corina P D Moniruzzaman, Mohammad Aylward, Frank O Chlamydomonas reinhardtii Genome, Viral Giant Viruses Virus Latency DNA Transposable Elements Virus Integration Cryptic infection of a giant virus in a unicellular green alga. Erazo-Garcia, Maria P Sheyn, Uri Barth, Zachary K Craig, Rory J Wessman, Petronella Jivaji, Abdeali M Ray, W Keith Svensson-Coelho, Maria Cornwallis, Charlie K Rengefors, Karin Brussaard, Corina P D Moniruzzaman, Mohammad Aylward, Frank O Chlamydomonas reinhardtii Genome, Viral Giant Viruses Virus Latency DNA Transposable Elements Virus Integration Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. In this work, we describe a 617-kilo-base pairs integrated giant viral element in the model green alga . We resolved the integrated viral genome using long-read sequencing, identified a putative polintovirus-like integrase, and show that viral particles accumulate primarily during the stationary growth phase. A diverse array of viral-encoded selfish genetic elements is expressed during viral activity, including several Fanzor nuclease-encoding transposable elements. In addition, we show that field isolates of spp. harbor signatures of endogenous giant viruses related to the virus that exhibit similar infection dynamics, suggesting that giant virus latency is prevalent in natural host communities. Our work describes an unusually large temperate virus of a unicellular eukaryote, substantially expanding the scope of cryptic viral infections in the virosphere. |
| title | Cryptic infection of a giant virus in a unicellular green alga. |
| topic | Chlamydomonas reinhardtii Genome, Viral Giant Viruses Virus Latency DNA Transposable Elements Virus Integration |
| url | https://pubmed.ncbi.nlm.nih.gov/40208960/ |