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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
The ISME journal
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40214158/ |
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| _version_ | 1868266216499445762 |
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| author | Sanchez-Martinez, Rodrigo Arani, Akash Krupovic, Mart Weitz, Joshua S Santos, Fernando Antón, Josefa |
| author_facet | Sanchez-Martinez, Rodrigo Arani, Akash Krupovic, Mart Weitz, Joshua S Santos, Fernando Antón, Josefa Sanchez-Martinez, Rodrigo Arani, Akash Krupovic, Mart Weitz, Joshua S Santos, Fernando Antón, Josefa |
| collection | PubMed - marine biology |
| contents | Episomal virus maintenance enables bacterial population recovery from infection and promotes virus-bacterial coexistence. Sanchez-Martinez, Rodrigo Arani, Akash Krupovic, Mart Weitz, Joshua S Santos, Fernando Antón, Josefa Plasmids Bacteriophages Bacteroidetes Viruses are ubiquitous in aquatic environments with total densities of virus-like particles often exceeding 107/ml in surface marine oligotrophic waters. Hypersaline environments harbor elevated prokaryotic population densities of 108/ml that coexist with viruses at even higher densities, approaching 1010/ml. The presence of high densities of microbial populations and viruses challenge traditional explanations of top-down control exerted by viruses. At close to saturation salinities, prokaryotic populations are dominated by Archaea and the bacterial genus Salinibacter. In this work we examine the episomal maintenance of a virus within a Salinibacter ruber host. We found that infected cultures of Sal. ruber M1 developed a population-level resistance and underwent systematic and reproducible recovery post infection that was counter-intuitively dependent on the multiplicity of infection, where higher viral pressures led to better host outcomes. Furthermore, we developed a nonlinear population dynamics model that successfully reproduced the qualitative features of the recovery. Together, experiments and models suggest that episomal virus maintenance and lysis inhibition enable host-virus co-existence at high viral densities. Our results emphasize the ecological importance of exploring a spectrum of viral infection strategies beyond the conventional binary of lysis or lysogeny. |
| format | Artículo científico |
| id | pubmed_40214158 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | The ISME journal |
| record_format | pubmed |
| spellingShingle | Episomal virus maintenance enables bacterial population recovery from infection and promotes virus-bacterial coexistence. Sanchez-Martinez, Rodrigo Arani, Akash Krupovic, Mart Weitz, Joshua S Santos, Fernando Antón, Josefa Plasmids Bacteriophages Bacteroidetes Episomal virus maintenance enables bacterial population recovery from infection and promotes virus-bacterial coexistence. Sanchez-Martinez, Rodrigo Arani, Akash Krupovic, Mart Weitz, Joshua S Santos, Fernando Antón, Josefa Plasmids Bacteriophages Bacteroidetes Viruses are ubiquitous in aquatic environments with total densities of virus-like particles often exceeding 107/ml in surface marine oligotrophic waters. Hypersaline environments harbor elevated prokaryotic population densities of 108/ml that coexist with viruses at even higher densities, approaching 1010/ml. The presence of high densities of microbial populations and viruses challenge traditional explanations of top-down control exerted by viruses. At close to saturation salinities, prokaryotic populations are dominated by Archaea and the bacterial genus Salinibacter. In this work we examine the episomal maintenance of a virus within a Salinibacter ruber host. We found that infected cultures of Sal. ruber M1 developed a population-level resistance and underwent systematic and reproducible recovery post infection that was counter-intuitively dependent on the multiplicity of infection, where higher viral pressures led to better host outcomes. Furthermore, we developed a nonlinear population dynamics model that successfully reproduced the qualitative features of the recovery. Together, experiments and models suggest that episomal virus maintenance and lysis inhibition enable host-virus co-existence at high viral densities. Our results emphasize the ecological importance of exploring a spectrum of viral infection strategies beyond the conventional binary of lysis or lysogeny. |
| title | Episomal virus maintenance enables bacterial population recovery from infection and promotes virus-bacterial coexistence. |
| topic | Plasmids Bacteriophages Bacteroidetes |
| url | https://pubmed.ncbi.nlm.nih.gov/40214158/ |