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| Autori principali: | , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Computational and structural biotechnology journal
2025
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| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/40235637/ |
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| _version_ | 1868266216476377088 |
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| author | Su, Fang Dolmatov, Igor Yu Wang, Tianming Yang, Hongsheng Ding, Kui Zhang, Libin Sun, Lina |
| author_facet | Su, Fang Dolmatov, Igor Yu Wang, Tianming Yang, Hongsheng Ding, Kui Zhang, Libin Sun, Lina Su, Fang Dolmatov, Igor Yu Wang, Tianming Yang, Hongsheng Ding, Kui Zhang, Libin Sun, Lina |
| collection | PubMed - marine biology |
| contents | LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumber . Su, Fang Dolmatov, Igor Yu Wang, Tianming Yang, Hongsheng Ding, Kui Zhang, Libin Sun, Lina The sea cucumber , renowned for its remarkable ability to expel and regenerate its internal organs within weeks, serves as a model organism for regeneration research. However, studies on the role of non-coding RNAs, particularly long non-coding RNA (lncRNA), in intestinal regeneration remain limited. In this study, we identified and performed differential expression analysis of lncRNAs in both normal intestines and intestines at 3 days post evisceration (dpe). A total of 2361 lncRNAs were identified, 183 of which were differentially expressed (DE-lncRNAs). The genes targeted by these lncRNAs, either cis- or trans-acting, were involved in oxidative stress, immune response, extracellular matrix remodeling, and energy metabolism during intestinal regeneration. Notably, MSTRG.6200/miR-7847-3p and MSTRG.18440/miR-4220-5p have been confirmed as interacting lncRNA-miRNA pairs. These results suggest that lncRNAs are key regulators of intestinal regeneration in , offering new insights into the underlying mechanisms and potential targets for enhancing regeneration. |
| format | Artículo científico |
| id | pubmed_40235637 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Computational and structural biotechnology journal |
| record_format | pubmed |
| spellingShingle | LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumber . Su, Fang Dolmatov, Igor Yu Wang, Tianming Yang, Hongsheng Ding, Kui Zhang, Libin Sun, Lina LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumber . Su, Fang Dolmatov, Igor Yu Wang, Tianming Yang, Hongsheng Ding, Kui Zhang, Libin Sun, Lina The sea cucumber , renowned for its remarkable ability to expel and regenerate its internal organs within weeks, serves as a model organism for regeneration research. However, studies on the role of non-coding RNAs, particularly long non-coding RNA (lncRNA), in intestinal regeneration remain limited. In this study, we identified and performed differential expression analysis of lncRNAs in both normal intestines and intestines at 3 days post evisceration (dpe). A total of 2361 lncRNAs were identified, 183 of which were differentially expressed (DE-lncRNAs). The genes targeted by these lncRNAs, either cis- or trans-acting, were involved in oxidative stress, immune response, extracellular matrix remodeling, and energy metabolism during intestinal regeneration. Notably, MSTRG.6200/miR-7847-3p and MSTRG.18440/miR-4220-5p have been confirmed as interacting lncRNA-miRNA pairs. These results suggest that lncRNAs are key regulators of intestinal regeneration in , offering new insights into the underlying mechanisms and potential targets for enhancing regeneration. |
| title | LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumber . |
| url | https://pubmed.ncbi.nlm.nih.gov/40235637/ |