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| Autores principales: | , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Computational and structural biotechnology journal
2025
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| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/40235637/ |
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- LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumber . Su, Fang Dolmatov, Igor Yu Wang, Tianming Yang, Hongsheng Ding, Kui Zhang, Libin Sun, Lina The sea cucumber , renowned for its remarkable ability to expel and regenerate its internal organs within weeks, serves as a model organism for regeneration research. However, studies on the role of non-coding RNAs, particularly long non-coding RNA (lncRNA), in intestinal regeneration remain limited. In this study, we identified and performed differential expression analysis of lncRNAs in both normal intestines and intestines at 3 days post evisceration (dpe). A total of 2361 lncRNAs were identified, 183 of which were differentially expressed (DE-lncRNAs). The genes targeted by these lncRNAs, either cis- or trans-acting, were involved in oxidative stress, immune response, extracellular matrix remodeling, and energy metabolism during intestinal regeneration. Notably, MSTRG.6200/miR-7847-3p and MSTRG.18440/miR-4220-5p have been confirmed as interacting lncRNA-miRNA pairs. These results suggest that lncRNAs are key regulators of intestinal regeneration in , offering new insights into the underlying mechanisms and potential targets for enhancing regeneration.