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| Autores principales: | , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Current biology : CB
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/40239658/ |
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| _version_ | 1868266216469037057 |
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| author | Richa, Prachi Häring, Matthias Wang, Qiyan Choudhury, Ankit Roy Göpfert, Martin C Wolf, Fred Großhans, Jörg Kong, Deqing |
| author_facet | Richa, Prachi Häring, Matthias Wang, Qiyan Choudhury, Ankit Roy Göpfert, Martin C Wolf, Fred Großhans, Jörg Kong, Deqing Richa, Prachi Häring, Matthias Wang, Qiyan Choudhury, Ankit Roy Göpfert, Martin C Wolf, Fred Großhans, Jörg Kong, Deqing |
| collection | PubMed - marine biology |
| contents | Synchronization in epithelial tissue morphogenesis. Richa, Prachi Häring, Matthias Wang, Qiyan Choudhury, Ankit Roy Göpfert, Martin C Wolf, Fred Großhans, Jörg Kong, Deqing Animals Morphogenesis Drosophila melanogaster Drosophila Proteins Mechanotransduction, Cellular Epithelium Embryo, Nonmammalian Epithelial Cells Cell Communication Coordination of cell behavior is central to morphogenesis, when arrays of cells simultaneously undergo shape changes or dynamic rearrangements. In epithelia, cell shape changes invariably exert mechanical forces, which adjacent cells could sense to trigger an active response. However, molecular mechanisms for such mechano-transduction and especially their role for tissue-wide coordination in morphogenesis have remained ambiguous. Here, we investigate the function of Tmc, a key component of cellular mechano-transduction in vertebrate hearing, for coordination of cell dynamics in the epithelial amnioserosa of Drosophila embryos. We directly probed cell-cell mechano-transduction in vivo by opto-chemically inducing single-cell contractions and discovered a Tmc-dependent contraction response in neighboring cell groups. On the tissue scale, we uncover synchronization of neighboring cell area oscillations, which is impaired in Tmc mutants. A data-driven model of Tmc-dependent cell-cell interactions predicts that synchronization leads to an isotropic force map and effectively shields the tissue from external mechanical pulling. By microdissection, we detect equal junction tension along the axial and lateral axis in wild-type but increased lateral tension in Tmc mutants. Thus, Tmc transduces forces into an intracellular response that coordinates mechanical cell behavior in epithelial tissue. |
| format | Artículo científico |
| id | pubmed_40239658 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Current biology : CB |
| record_format | pubmed |
| spellingShingle | Synchronization in epithelial tissue morphogenesis. Richa, Prachi Häring, Matthias Wang, Qiyan Choudhury, Ankit Roy Göpfert, Martin C Wolf, Fred Großhans, Jörg Kong, Deqing Animals Morphogenesis Drosophila melanogaster Drosophila Proteins Mechanotransduction, Cellular Epithelium Embryo, Nonmammalian Epithelial Cells Cell Communication Synchronization in epithelial tissue morphogenesis. Richa, Prachi Häring, Matthias Wang, Qiyan Choudhury, Ankit Roy Göpfert, Martin C Wolf, Fred Großhans, Jörg Kong, Deqing Animals Morphogenesis Drosophila melanogaster Drosophila Proteins Mechanotransduction, Cellular Epithelium Embryo, Nonmammalian Epithelial Cells Cell Communication Coordination of cell behavior is central to morphogenesis, when arrays of cells simultaneously undergo shape changes or dynamic rearrangements. In epithelia, cell shape changes invariably exert mechanical forces, which adjacent cells could sense to trigger an active response. However, molecular mechanisms for such mechano-transduction and especially their role for tissue-wide coordination in morphogenesis have remained ambiguous. Here, we investigate the function of Tmc, a key component of cellular mechano-transduction in vertebrate hearing, for coordination of cell dynamics in the epithelial amnioserosa of Drosophila embryos. We directly probed cell-cell mechano-transduction in vivo by opto-chemically inducing single-cell contractions and discovered a Tmc-dependent contraction response in neighboring cell groups. On the tissue scale, we uncover synchronization of neighboring cell area oscillations, which is impaired in Tmc mutants. A data-driven model of Tmc-dependent cell-cell interactions predicts that synchronization leads to an isotropic force map and effectively shields the tissue from external mechanical pulling. By microdissection, we detect equal junction tension along the axial and lateral axis in wild-type but increased lateral tension in Tmc mutants. Thus, Tmc transduces forces into an intracellular response that coordinates mechanical cell behavior in epithelial tissue. |
| title | Synchronization in epithelial tissue morphogenesis. |
| topic | Animals Morphogenesis Drosophila melanogaster Drosophila Proteins Mechanotransduction, Cellular Epithelium Embryo, Nonmammalian Epithelial Cells Cell Communication |
| url | https://pubmed.ncbi.nlm.nih.gov/40239658/ |