antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation.
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| Sprache: | en |
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Nucleic acids research
2025
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| author | Blin, Kai Shaw, Simon Vader, Lisa Szenei, Judit Reitz, Zachary L Augustijn, Hannah E Cediel-Becerra, José D D de Crécy-Lagard, Valérie Koetsier, Robert A Williams, Sam E Cruz-Morales, Pablo Wongwas, Sopida Segurado Luchsinger, Alejandro E Biermann, Friederike Korenskaia, Aleksandra Zdouc, Mitja M Meijer, David Terlouw, Barbara R van der Hooft, Justin J J Ziemert, Nadine Helfrich, Eric J N Masschelein, Joleen Corre, Christophe Chevrette, Marc G van Wezel, Gilles P Medema, Marnix H Weber, Tilmann |
| author_facet | Blin, Kai Shaw, Simon Vader, Lisa Szenei, Judit Reitz, Zachary L Augustijn, Hannah E Cediel-Becerra, José D D de Crécy-Lagard, Valérie Koetsier, Robert A Williams, Sam E Cruz-Morales, Pablo Wongwas, Sopida Segurado Luchsinger, Alejandro E Biermann, Friederike Korenskaia, Aleksandra Zdouc, Mitja M Meijer, David Terlouw, Barbara R van der Hooft, Justin J J Ziemert, Nadine Helfrich, Eric J N Masschelein, Joleen Corre, Christophe Chevrette, Marc G van Wezel, Gilles P Medema, Marnix H Weber, Tilmann Blin, Kai Shaw, Simon Vader, Lisa Szenei, Judit Reitz, Zachary L Augustijn, Hannah E Cediel-Becerra, José D D de Crécy-Lagard, Valérie Koetsier, Robert A Williams, Sam E Cruz-Morales, Pablo Wongwas, Sopida Segurado Luchsinger, Alejandro E Biermann, Friederike Korenskaia, Aleksandra Zdouc, Mitja M Meijer, David Terlouw, Barbara R van der Hooft, Justin J J Ziemert, Nadine Helfrich, Eric J N Masschelein, Joleen Corre, Christophe Chevrette, Marc G van Wezel, Gilles P Medema, Marnix H Weber, Tilmann |
| collection | PubMed - marine biology |
| contents | antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation. Blin, Kai Shaw, Simon Vader, Lisa Szenei, Judit Reitz, Zachary L Augustijn, Hannah E Cediel-Becerra, José D D de Crécy-Lagard, Valérie Koetsier, Robert A Williams, Sam E Cruz-Morales, Pablo Wongwas, Sopida Segurado Luchsinger, Alejandro E Biermann, Friederike Korenskaia, Aleksandra Zdouc, Mitja M Meijer, David Terlouw, Barbara R van der Hooft, Justin J J Ziemert, Nadine Helfrich, Eric J N Masschelein, Joleen Corre, Christophe Chevrette, Marc G van Wezel, Gilles P Medema, Marnix H Weber, Tilmann Multigene Family Genetic Techniques Software Polyketide Synthases Peptide Synthases Terpenes Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in microbial interactions and soil health, but are also crucial for the development of pharmaceuticals or agrochemicals. Over the past decades, advancements in genome sequencing have enabled the identification of large numbers of biosynthetic gene clusters directly from microbial genomes. Since its inception in 2011, antiSMASH (https://antismash.secondarymetabolites.org/), has become the leading tool for detecting and characterizing these gene clusters in bacteria and fungi. This paper introduces version 8 of antiSMASH, which has increased the number of detectable cluster types from 81 to 101, and has improved analysis support for terpenoids and tailoring enzymes, as well as improvements in the analysis of modular enzymes like polyketide synthases and nonribosomal peptide synthetases. These modifications keep antiSMASH up-to-date with developments in the field and extend its overall predictive capabilities for natural product genome mining. |
| format | Artículo científico |
| id | pubmed_40276974 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Nucleic acids research |
| record_format | pubmed |
| spellingShingle | antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation. Blin, Kai Shaw, Simon Vader, Lisa Szenei, Judit Reitz, Zachary L Augustijn, Hannah E Cediel-Becerra, José D D de Crécy-Lagard, Valérie Koetsier, Robert A Williams, Sam E Cruz-Morales, Pablo Wongwas, Sopida Segurado Luchsinger, Alejandro E Biermann, Friederike Korenskaia, Aleksandra Zdouc, Mitja M Meijer, David Terlouw, Barbara R van der Hooft, Justin J J Ziemert, Nadine Helfrich, Eric J N Masschelein, Joleen Corre, Christophe Chevrette, Marc G van Wezel, Gilles P Medema, Marnix H Weber, Tilmann Multigene Family Genetic Techniques Software Polyketide Synthases Peptide Synthases Terpenes antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation. Blin, Kai Shaw, Simon Vader, Lisa Szenei, Judit Reitz, Zachary L Augustijn, Hannah E Cediel-Becerra, José D D de Crécy-Lagard, Valérie Koetsier, Robert A Williams, Sam E Cruz-Morales, Pablo Wongwas, Sopida Segurado Luchsinger, Alejandro E Biermann, Friederike Korenskaia, Aleksandra Zdouc, Mitja M Meijer, David Terlouw, Barbara R van der Hooft, Justin J J Ziemert, Nadine Helfrich, Eric J N Masschelein, Joleen Corre, Christophe Chevrette, Marc G van Wezel, Gilles P Medema, Marnix H Weber, Tilmann Multigene Family Genetic Techniques Software Polyketide Synthases Peptide Synthases Terpenes Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in microbial interactions and soil health, but are also crucial for the development of pharmaceuticals or agrochemicals. Over the past decades, advancements in genome sequencing have enabled the identification of large numbers of biosynthetic gene clusters directly from microbial genomes. Since its inception in 2011, antiSMASH (https://antismash.secondarymetabolites.org/), has become the leading tool for detecting and characterizing these gene clusters in bacteria and fungi. This paper introduces version 8 of antiSMASH, which has increased the number of detectable cluster types from 81 to 101, and has improved analysis support for terpenoids and tailoring enzymes, as well as improvements in the analysis of modular enzymes like polyketide synthases and nonribosomal peptide synthetases. These modifications keep antiSMASH up-to-date with developments in the field and extend its overall predictive capabilities for natural product genome mining. |
| title | antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation. |
| topic | Multigene Family Genetic Techniques Software Polyketide Synthases Peptide Synthases Terpenes |
| url | https://pubmed.ncbi.nlm.nih.gov/40276974/ |