Novel Insights and Genomic Characterization of Coral-Associated Microorganisms from Maldives Displaying Antimicrobial, Antioxidant, and UV-Protectant Activities.
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Biology
2025
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| _version_ | 1868266211771416577 |
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| author | Palma Esposito, Fortunato López-Mobilia, Andrea Tangherlini, Michael Casella, Vincenza Coppola, Alessandro Varola, Giulia Vitale, Laura Della Sala, Gerardo Tedesco, Pietro Montano, Simone Seveso, Davide Galli, Paolo Coppola, Daniela de Pascale, Donatella Galasso, Christian |
| author_facet | Palma Esposito, Fortunato López-Mobilia, Andrea Tangherlini, Michael Casella, Vincenza Coppola, Alessandro Varola, Giulia Vitale, Laura Della Sala, Gerardo Tedesco, Pietro Montano, Simone Seveso, Davide Galli, Paolo Coppola, Daniela de Pascale, Donatella Galasso, Christian Palma Esposito, Fortunato López-Mobilia, Andrea Tangherlini, Michael Casella, Vincenza Coppola, Alessandro Varola, Giulia Vitale, Laura Della Sala, Gerardo Tedesco, Pietro Montano, Simone Seveso, Davide Galli, Paolo Coppola, Daniela de Pascale, Donatella Galasso, Christian |
| collection | PubMed - marine biology |
| contents | Novel Insights and Genomic Characterization of Coral-Associated Microorganisms from Maldives Displaying Antimicrobial, Antioxidant, and UV-Protectant Activities. Palma Esposito, Fortunato López-Mobilia, Andrea Tangherlini, Michael Casella, Vincenza Coppola, Alessandro Varola, Giulia Vitale, Laura Della Sala, Gerardo Tedesco, Pietro Montano, Simone Seveso, Davide Galli, Paolo Coppola, Daniela de Pascale, Donatella Galasso, Christian Coral reef survival is crucial for the socio-ecological interest of many countries, particularly for the Republic of Maldives, whose reef integrity influences the country's livelihoods and economy. These ecosystems are being severely impacted by multiple stressors, leading to declines in biodiversity. In the last few decades, researchers have focused on studying coral-associated microorganisms (CAMs) and their symbiotic role in coral health and resilience. Metabarcoding analysis has been widely utilized to study CAM diversity under various conditions but provides limited information on their functional roles. Therefore, cultivation of bacterial strains remains indispensable for validating ecological and biotechnological hypotheses. In this study, we investigated the microbial community associated with two abundant corals in Maldives, and , and evaluated the antimicrobial, antioxidant, and UV-protectant properties of 10 promising isolated strains. The selected CAMs, 39, 79, sp. 92 (a potential novel species), and 93, exhibited antibiotic activity against a panel of pathogenic strains (MIC from 0.01 to 500 µg/mL), antioxidant (comparable effect to that of Trolox and ascorbic acid), and UV-screen activities (protection of human keratinocytes at 200 µg/mL). Genomes revealed their dual potential in contributing to coral restoration and drug discovery strategies. These findings highlight the biotechnological relevance of CAMs, representing an important step toward the identification of novel and bioactive bacterial species beneficial for coral reef ecosystems and human health. |
| format | Artículo científico |
| id | pubmed_40282266 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Biology |
| record_format | pubmed |
| spellingShingle | Novel Insights and Genomic Characterization of Coral-Associated Microorganisms from Maldives Displaying Antimicrobial, Antioxidant, and UV-Protectant Activities. Palma Esposito, Fortunato López-Mobilia, Andrea Tangherlini, Michael Casella, Vincenza Coppola, Alessandro Varola, Giulia Vitale, Laura Della Sala, Gerardo Tedesco, Pietro Montano, Simone Seveso, Davide Galli, Paolo Coppola, Daniela de Pascale, Donatella Galasso, Christian Novel Insights and Genomic Characterization of Coral-Associated Microorganisms from Maldives Displaying Antimicrobial, Antioxidant, and UV-Protectant Activities. Palma Esposito, Fortunato López-Mobilia, Andrea Tangherlini, Michael Casella, Vincenza Coppola, Alessandro Varola, Giulia Vitale, Laura Della Sala, Gerardo Tedesco, Pietro Montano, Simone Seveso, Davide Galli, Paolo Coppola, Daniela de Pascale, Donatella Galasso, Christian Coral reef survival is crucial for the socio-ecological interest of many countries, particularly for the Republic of Maldives, whose reef integrity influences the country's livelihoods and economy. These ecosystems are being severely impacted by multiple stressors, leading to declines in biodiversity. In the last few decades, researchers have focused on studying coral-associated microorganisms (CAMs) and their symbiotic role in coral health and resilience. Metabarcoding analysis has been widely utilized to study CAM diversity under various conditions but provides limited information on their functional roles. Therefore, cultivation of bacterial strains remains indispensable for validating ecological and biotechnological hypotheses. In this study, we investigated the microbial community associated with two abundant corals in Maldives, and , and evaluated the antimicrobial, antioxidant, and UV-protectant properties of 10 promising isolated strains. The selected CAMs, 39, 79, sp. 92 (a potential novel species), and 93, exhibited antibiotic activity against a panel of pathogenic strains (MIC from 0.01 to 500 µg/mL), antioxidant (comparable effect to that of Trolox and ascorbic acid), and UV-screen activities (protection of human keratinocytes at 200 µg/mL). Genomes revealed their dual potential in contributing to coral restoration and drug discovery strategies. These findings highlight the biotechnological relevance of CAMs, representing an important step toward the identification of novel and bioactive bacterial species beneficial for coral reef ecosystems and human health. |
| title | Novel Insights and Genomic Characterization of Coral-Associated Microorganisms from Maldives Displaying Antimicrobial, Antioxidant, and UV-Protectant Activities. |
| url | https://pubmed.ncbi.nlm.nih.gov/40282266/ |