Production and Characterization of Poly-γ-Glutamic Acid by SDU.
Fuente:
PubMed
Salvato in:
| Autori principali: | , , , , , , , , |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Microorganisms
2025
|
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1868266211766173698 |
|---|---|
| author | Guo, Guangyao Wang, Han Jia, Huiyuan Ni, Haiping Xu, Shouying Zhang, Cuiying Zhang, Youming Wu, Yuxia Tu, Qiang |
| author_facet | Guo, Guangyao Wang, Han Jia, Huiyuan Ni, Haiping Xu, Shouying Zhang, Cuiying Zhang, Youming Wu, Yuxia Tu, Qiang Guo, Guangyao Wang, Han Jia, Huiyuan Ni, Haiping Xu, Shouying Zhang, Cuiying Zhang, Youming Wu, Yuxia Tu, Qiang |
| collection | PubMed - marine biology |
| contents | Production and Characterization of Poly-γ-Glutamic Acid by SDU. Guo, Guangyao Wang, Han Jia, Huiyuan Ni, Haiping Xu, Shouying Zhang, Cuiying Zhang, Youming Wu, Yuxia Tu, Qiang In this study, a SDU strain capable of producing poly-γ-glutamate (γ-PGA) was newly identified from the rhizosphere soil of Baimiao taro. The strain is a glutamate-independent strain and can produce polyglutamic acid in a culture medium completely free of glutamate. The hydrolyzed product of the polyglutamic acid produced is D-glutamic acid. The molecular weight of γ-PGA, estimated via the Mark-Houwink equation, was 1390 kDa. Furthermore, the molecular weight measured by Waters gel permeation chromatography with multi-angle laser light scattering (GPC-MALLS) was 1167 kDa. The production of γ-PGA and its antioxidant and tyrosine inhibition properties were investigated. The γ-PGA production reached 23.1 g/L, and the productivity was 0.77 g L h. Specifically, γ-PGA exhibited superoxide anion (·O) radical scavenging activity and tyrosinase inhibitory activity. This study introduces a promising strain and a highly efficient application method for γ-PGA, which can be broadly utilized in the pharmaceutical, food, and cosmetic industries. |
| format | Artículo científico |
| id | pubmed_40284754 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Microorganisms |
| record_format | pubmed |
| spellingShingle | Production and Characterization of Poly-γ-Glutamic Acid by SDU. Guo, Guangyao Wang, Han Jia, Huiyuan Ni, Haiping Xu, Shouying Zhang, Cuiying Zhang, Youming Wu, Yuxia Tu, Qiang Production and Characterization of Poly-γ-Glutamic Acid by SDU. Guo, Guangyao Wang, Han Jia, Huiyuan Ni, Haiping Xu, Shouying Zhang, Cuiying Zhang, Youming Wu, Yuxia Tu, Qiang In this study, a SDU strain capable of producing poly-γ-glutamate (γ-PGA) was newly identified from the rhizosphere soil of Baimiao taro. The strain is a glutamate-independent strain and can produce polyglutamic acid in a culture medium completely free of glutamate. The hydrolyzed product of the polyglutamic acid produced is D-glutamic acid. The molecular weight of γ-PGA, estimated via the Mark-Houwink equation, was 1390 kDa. Furthermore, the molecular weight measured by Waters gel permeation chromatography with multi-angle laser light scattering (GPC-MALLS) was 1167 kDa. The production of γ-PGA and its antioxidant and tyrosine inhibition properties were investigated. The γ-PGA production reached 23.1 g/L, and the productivity was 0.77 g L h. Specifically, γ-PGA exhibited superoxide anion (·O) radical scavenging activity and tyrosinase inhibitory activity. This study introduces a promising strain and a highly efficient application method for γ-PGA, which can be broadly utilized in the pharmaceutical, food, and cosmetic industries. |
| title | Production and Characterization of Poly-γ-Glutamic Acid by SDU. |
| url | https://pubmed.ncbi.nlm.nih.gov/40284754/ |