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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Microorganisms
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40284754/ |
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Table of Contents:
- Production and Characterization of Poly-γ-Glutamic Acid by SDU. Guo, Guangyao Wang, Han Jia, Huiyuan Ni, Haiping Xu, Shouying Zhang, Cuiying Zhang, Youming Wu, Yuxia Tu, Qiang In this study, a SDU strain capable of producing poly-γ-glutamate (γ-PGA) was newly identified from the rhizosphere soil of Baimiao taro. The strain is a glutamate-independent strain and can produce polyglutamic acid in a culture medium completely free of glutamate. The hydrolyzed product of the polyglutamic acid produced is D-glutamic acid. The molecular weight of γ-PGA, estimated via the Mark-Houwink equation, was 1390 kDa. Furthermore, the molecular weight measured by Waters gel permeation chromatography with multi-angle laser light scattering (GPC-MALLS) was 1167 kDa. The production of γ-PGA and its antioxidant and tyrosine inhibition properties were investigated. The γ-PGA production reached 23.1 g/L, and the productivity was 0.77 g L h. Specifically, γ-PGA exhibited superoxide anion (·O) radical scavenging activity and tyrosinase inhibitory activity. This study introduces a promising strain and a highly efficient application method for γ-PGA, which can be broadly utilized in the pharmaceutical, food, and cosmetic industries.