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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Molecules (Basel, Switzerland)
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40286106/ |
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| _version_ | 1868266211765125120 |
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| author | Jiao, Fangwen Liu, Tianyu Wang, Kaiwei Li, Shuai Jiao, Ruihua Lin, Wei |
| author_facet | Jiao, Fangwen Liu, Tianyu Wang, Kaiwei Li, Shuai Jiao, Ruihua Lin, Wei Jiao, Fangwen Liu, Tianyu Wang, Kaiwei Li, Shuai Jiao, Ruihua Lin, Wei |
| collection | PubMed - marine biology |
| contents | Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus sp. NF666. Jiao, Fangwen Liu, Tianyu Wang, Kaiwei Li, Shuai Jiao, Ruihua Lin, Wei Aspergillus Pyrrolidinones Microbial Sensitivity Tests Molecular Structure Anti-Bacterial Agents Magnetic Resonance Spectroscopy Aquatic Organisms Naphthalenes Two new decalin-tetramic acid hybrid metabolites, zopfiellamides C () and D () were isolated from the marine-derived fungus sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data analyses including COSY, HSQC, HMBC, and NOESY experiments. Both isolated metabolites ( and ) exhibited significant growth inhibition against four clinically relevant bacterial strains with minimum inhibitory concentration (MIC) values of about 12.5 μΜ. Moreover, we proposed a plausible biosynthetic pathway of zopfiellamide D () in this work. |
| format | Artículo científico |
| id | pubmed_40286106 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Molecules (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus sp. NF666. Jiao, Fangwen Liu, Tianyu Wang, Kaiwei Li, Shuai Jiao, Ruihua Lin, Wei Aspergillus Pyrrolidinones Microbial Sensitivity Tests Molecular Structure Anti-Bacterial Agents Magnetic Resonance Spectroscopy Aquatic Organisms Naphthalenes Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus sp. NF666. Jiao, Fangwen Liu, Tianyu Wang, Kaiwei Li, Shuai Jiao, Ruihua Lin, Wei Aspergillus Pyrrolidinones Microbial Sensitivity Tests Molecular Structure Anti-Bacterial Agents Magnetic Resonance Spectroscopy Aquatic Organisms Naphthalenes Two new decalin-tetramic acid hybrid metabolites, zopfiellamides C () and D () were isolated from the marine-derived fungus sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data analyses including COSY, HSQC, HMBC, and NOESY experiments. Both isolated metabolites ( and ) exhibited significant growth inhibition against four clinically relevant bacterial strains with minimum inhibitory concentration (MIC) values of about 12.5 μΜ. Moreover, we proposed a plausible biosynthetic pathway of zopfiellamide D () in this work. |
| title | Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus sp. NF666. |
| topic | Aspergillus Pyrrolidinones Microbial Sensitivity Tests Molecular Structure Anti-Bacterial Agents Magnetic Resonance Spectroscopy Aquatic Organisms Naphthalenes |
| url | https://pubmed.ncbi.nlm.nih.gov/40286106/ |