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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine pollution bulletin
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40286414/ |
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| _version_ | 1868266211763027971 |
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| author | Mu, Jiahang Kang, Zhang Lu, Jinjin Fang, Junhua Zhang, Li Zhou, Kefu |
| author_facet | Mu, Jiahang Kang, Zhang Lu, Jinjin Fang, Junhua Zhang, Li Zhou, Kefu Mu, Jiahang Kang, Zhang Lu, Jinjin Fang, Junhua Zhang, Li Zhou, Kefu |
| collection | PubMed - marine biology |
| contents | Investigation on the inactivation of Prorocentrum lima and degradation of diarrhetic shellfish toxins via peroxymonosulfate-based advanced oxidation process. Mu, Jiahang Kang, Zhang Lu, Jinjin Fang, Junhua Zhang, Li Zhou, Kefu Marine Toxins Oxidation-Reduction Dinoflagellida Harmful Algal Bloom Peroxides Animals Shellfish Poisoning Mice Prorocentrum lima, a frequent harmful algal bloom species, secretes diarrhetic shellfish toxins (DSTs) that cause severe human gastrointestinal disorders. This study investigated a peroxymonosulfate (PMS)-based advanced oxidation process utilizing sulfate radicals for simultaneous algal inactivation and toxin degradation, addressing the current research gap in marine algal control. Microscopic analyses (optical/SEM) revealed structural disintegration and cytoplasmic leakage in treated cells. The observed 45.55-69.24 % reduction in chlorophyll a concentration critically impaired photosynthetic activity and DSTs biosynthesis. A 94.68 % decrease in viable cell ratio after 5 h PMS exposure confirmed effective algal eradication. Complementary mouse bioassays and LC-MS quantification demonstrated progressive toxin detoxification, evidenced by extended survival times and reduced DSTs concentrations. Membrane integrity analysis showed characteristic oxidative stress responses: malondialdehyde (MDA) levels surged during initial exposure (0-15 min), followed by superoxide dismutase (SOD) activity elevation (15-30 min) as cellular defense activation. The combined cell mortality and toxin attenuation confirm the dual efficacy of this approach. This cost-effective, operationally simple method presents a viable strategy for mitigating P. lima blooms and associated toxin hazards in marine environments. |
| format | Artículo científico |
| id | pubmed_40286414 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Marine pollution bulletin |
| record_format | pubmed |
| spellingShingle | Investigation on the inactivation of Prorocentrum lima and degradation of diarrhetic shellfish toxins via peroxymonosulfate-based advanced oxidation process. Mu, Jiahang Kang, Zhang Lu, Jinjin Fang, Junhua Zhang, Li Zhou, Kefu Marine Toxins Oxidation-Reduction Dinoflagellida Harmful Algal Bloom Peroxides Animals Shellfish Poisoning Mice Investigation on the inactivation of Prorocentrum lima and degradation of diarrhetic shellfish toxins via peroxymonosulfate-based advanced oxidation process. Mu, Jiahang Kang, Zhang Lu, Jinjin Fang, Junhua Zhang, Li Zhou, Kefu Marine Toxins Oxidation-Reduction Dinoflagellida Harmful Algal Bloom Peroxides Animals Shellfish Poisoning Mice Prorocentrum lima, a frequent harmful algal bloom species, secretes diarrhetic shellfish toxins (DSTs) that cause severe human gastrointestinal disorders. This study investigated a peroxymonosulfate (PMS)-based advanced oxidation process utilizing sulfate radicals for simultaneous algal inactivation and toxin degradation, addressing the current research gap in marine algal control. Microscopic analyses (optical/SEM) revealed structural disintegration and cytoplasmic leakage in treated cells. The observed 45.55-69.24 % reduction in chlorophyll a concentration critically impaired photosynthetic activity and DSTs biosynthesis. A 94.68 % decrease in viable cell ratio after 5 h PMS exposure confirmed effective algal eradication. Complementary mouse bioassays and LC-MS quantification demonstrated progressive toxin detoxification, evidenced by extended survival times and reduced DSTs concentrations. Membrane integrity analysis showed characteristic oxidative stress responses: malondialdehyde (MDA) levels surged during initial exposure (0-15 min), followed by superoxide dismutase (SOD) activity elevation (15-30 min) as cellular defense activation. The combined cell mortality and toxin attenuation confirm the dual efficacy of this approach. This cost-effective, operationally simple method presents a viable strategy for mitigating P. lima blooms and associated toxin hazards in marine environments. |
| title | Investigation on the inactivation of Prorocentrum lima and degradation of diarrhetic shellfish toxins via peroxymonosulfate-based advanced oxidation process. |
| topic | Marine Toxins Oxidation-Reduction Dinoflagellida Harmful Algal Bloom Peroxides Animals Shellfish Poisoning Mice |
| url | https://pubmed.ncbi.nlm.nih.gov/40286414/ |