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| Main Authors: | , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Fish & shellfish immunology
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40288618/ |
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Table of Contents:
- The gene characteristics and adaptive evolution of the tumor necrosis factor superfamily (TNFSF) in miiuy croaker, Miichthysmiiuy. Su, Xiaoqin Cui, Yanqiu Gong, Hanfu Xu, Tianjun Sun, Yuena Animals Fish Proteins Evolution, Molecular Phylogeny Sequence Alignment Amino Acid Sequence Tumor Necrosis Factors Perciformes Immunity, Innate The tumor necrosis factor superfamily (TNFSF) is crucial in regulating immune responses, with its members mediating various biological functions through key signaling pathways. However, the gene characteristics of this family and their comparative and evolutionary analysis across species remain limited. In this study, 12 TNFSF genes were identified in the genome-wide of miiuy croaker. Analyses were conducted on evolutionary relationships, conserved motifs, gene duplication, and selection pressure. Conserved motif analyses revealed that the C-terminal motifs of vertebrate TNFSF proteins were more conserved than the N-terminus. Sequence alignment and conservation analysis identified an unrecognized helix structure within the TNF homology domain, which exhibited structural conservation among vertebrates. Synteny and selection pressure analyses indicated that the TNFSF in miiuy croaker exhibited tandem and segmental duplication events. Evolutionary selection pressures may contributed to the functional differentiation of this family. These findings could enhance the understanding of TNFSF gene characteristics and evolutionary relationships, and provide new insights for studying immune-related TNFSF genes.