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| Natura: | Artículo científico |
| Lingua: | en |
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Molecular neurobiology
2025
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/40299300/ |
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| author | Wan, Ying Rong, Lu Li, Qingyuan Liu, Suzhi Li, Wentao Ye, Min Luo, Weifeng Xie, Anmu Shao, Jingsong Guo, Dengjun Zhang, Xiaoping Zhang, Kezhong Liu, Zhenguo |
| author_facet | Wan, Ying Rong, Lu Li, Qingyuan Liu, Suzhi Li, Wentao Ye, Min Luo, Weifeng Xie, Anmu Shao, Jingsong Guo, Dengjun Zhang, Xiaoping Zhang, Kezhong Liu, Zhenguo Wan, Ying Rong, Lu Li, Qingyuan Liu, Suzhi Li, Wentao Ye, Min Luo, Weifeng Xie, Anmu Shao, Jingsong Guo, Dengjun Zhang, Xiaoping Zhang, Kezhong Liu, Zhenguo |
| collection | PubMed - marine biology |
| contents | Integrative Approaches Identify Genetic Determinants of Levodopa Induced Dyskinesia. Wan, Ying Rong, Lu Li, Qingyuan Liu, Suzhi Li, Wentao Ye, Min Luo, Weifeng Xie, Anmu Shao, Jingsong Guo, Dengjun Zhang, Xiaoping Zhang, Kezhong Liu, Zhenguo Humans Levodopa Genome-Wide Association Study Dyskinesia, Drug-Induced Genetic Predisposition to Disease Male Female Polymorphism, Single Nucleotide Quantitative Trait Loci Parkinson Disease Middle Aged Aged Prospective Studies Levodopa induced dyskinesia (LID) is a serious side effect of levodopa treatment in Parkinson's disease (PD), with limited interventions. Understanding the genetic impact on LID would help inform future intervention studies. We performed integrative genomic analysis approaches to identify the genetic determinants of LID in a Chinese multi-center prospective, observational PD cohort. In this cohort, 46 of 315 PD patients developed LID during 2.5 years of follow-up. First, we performed a genome-wide association study (GWAS) in this cohort, followed by a meta-analysis integrating our GWAS summary data with additional data of European ancestry. Both GWAS analyses identified the Bromodomain Containing 3 (BRD3) as a LID susceptibility gene (P |
| format | Artículo científico |
| id | pubmed_40299300 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Molecular neurobiology |
| record_format | pubmed |
| spellingShingle | Integrative Approaches Identify Genetic Determinants of Levodopa Induced Dyskinesia. Wan, Ying Rong, Lu Li, Qingyuan Liu, Suzhi Li, Wentao Ye, Min Luo, Weifeng Xie, Anmu Shao, Jingsong Guo, Dengjun Zhang, Xiaoping Zhang, Kezhong Liu, Zhenguo Humans Levodopa Genome-Wide Association Study Dyskinesia, Drug-Induced Genetic Predisposition to Disease Male Female Polymorphism, Single Nucleotide Quantitative Trait Loci Parkinson Disease Middle Aged Aged Prospective Studies Integrative Approaches Identify Genetic Determinants of Levodopa Induced Dyskinesia. Wan, Ying Rong, Lu Li, Qingyuan Liu, Suzhi Li, Wentao Ye, Min Luo, Weifeng Xie, Anmu Shao, Jingsong Guo, Dengjun Zhang, Xiaoping Zhang, Kezhong Liu, Zhenguo Humans Levodopa Genome-Wide Association Study Dyskinesia, Drug-Induced Genetic Predisposition to Disease Male Female Polymorphism, Single Nucleotide Quantitative Trait Loci Parkinson Disease Middle Aged Aged Prospective Studies Levodopa induced dyskinesia (LID) is a serious side effect of levodopa treatment in Parkinson's disease (PD), with limited interventions. Understanding the genetic impact on LID would help inform future intervention studies. We performed integrative genomic analysis approaches to identify the genetic determinants of LID in a Chinese multi-center prospective, observational PD cohort. In this cohort, 46 of 315 PD patients developed LID during 2.5 years of follow-up. First, we performed a genome-wide association study (GWAS) in this cohort, followed by a meta-analysis integrating our GWAS summary data with additional data of European ancestry. Both GWAS analyses identified the Bromodomain Containing 3 (BRD3) as a LID susceptibility gene (P |
| title | Integrative Approaches Identify Genetic Determinants of Levodopa Induced Dyskinesia. |
| topic | Humans Levodopa Genome-Wide Association Study Dyskinesia, Drug-Induced Genetic Predisposition to Disease Male Female Polymorphism, Single Nucleotide Quantitative Trait Loci Parkinson Disease Middle Aged Aged Prospective Studies |
| url | https://pubmed.ncbi.nlm.nih.gov/40299300/ |