Diverse Secondary Metabolites From the Ligia exotica-Derived Fungus Diaporthe melitensis HZ-1.
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| Auteurs principaux: | , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
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Chemistry & biodiversity
2025
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| _version_ | 1868266209176190976 |
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| author | Zhu, Ming-Xin Hao, Yi Yan, Bing-Yuan Jin, Yang Gao, Zhen Li, Xu-Wen |
| author_facet | Zhu, Ming-Xin Hao, Yi Yan, Bing-Yuan Jin, Yang Gao, Zhen Li, Xu-Wen Zhu, Ming-Xin Hao, Yi Yan, Bing-Yuan Jin, Yang Gao, Zhen Li, Xu-Wen |
| collection | PubMed - marine biology |
| contents | Diverse Secondary Metabolites From the Ligia exotica-Derived Fungus Diaporthe melitensis HZ-1. Zhu, Ming-Xin Hao, Yi Yan, Bing-Yuan Jin, Yang Gao, Zhen Li, Xu-Wen Microbial Sensitivity Tests Anti-Bacterial Agents Ascomycota Molecular Structure Molecular Conformation Crystallography, X-Ray Density Functional Theory Biological Products Dose-Response Relationship, Drug One new phenolic derivative diameliresorcin (1), one new natural product N-(2'-oxopiperidin-3'-yl) picolinamide (2), one new α-pyrone derivative diameliphyone (3), and six known secondary metabolites (4-9) were isolated from the Ligia exotica-derived fungus Diaporthe melitensis HZ-1. The structures of three new compounds were identified by IR, NMR, and HR-ESI-MS, whereas their absolute configurations were validated either through single-crystal x-ray diffraction analysis or via time-dependent density functional theory (TDDFT)-electronic circular dichroism (ECD) calculations. It is noted that the absolute configuration of compound 2 was determined for the first time. Meanwhile, all the isolated compounds were evaluated for their antibacterial activities. Among them, diameliresorcin (1) exhibited weak anti-Vibrio vulnificus activity with minimum inhibitory concentration (MIC) value of 46 µg/mL. |
| format | Artículo científico |
| id | pubmed_40300654 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Chemistry & biodiversity |
| record_format | pubmed |
| spellingShingle | Diverse Secondary Metabolites From the Ligia exotica-Derived Fungus Diaporthe melitensis HZ-1. Zhu, Ming-Xin Hao, Yi Yan, Bing-Yuan Jin, Yang Gao, Zhen Li, Xu-Wen Microbial Sensitivity Tests Anti-Bacterial Agents Ascomycota Molecular Structure Molecular Conformation Crystallography, X-Ray Density Functional Theory Biological Products Dose-Response Relationship, Drug Diverse Secondary Metabolites From the Ligia exotica-Derived Fungus Diaporthe melitensis HZ-1. Zhu, Ming-Xin Hao, Yi Yan, Bing-Yuan Jin, Yang Gao, Zhen Li, Xu-Wen Microbial Sensitivity Tests Anti-Bacterial Agents Ascomycota Molecular Structure Molecular Conformation Crystallography, X-Ray Density Functional Theory Biological Products Dose-Response Relationship, Drug One new phenolic derivative diameliresorcin (1), one new natural product N-(2'-oxopiperidin-3'-yl) picolinamide (2), one new α-pyrone derivative diameliphyone (3), and six known secondary metabolites (4-9) were isolated from the Ligia exotica-derived fungus Diaporthe melitensis HZ-1. The structures of three new compounds were identified by IR, NMR, and HR-ESI-MS, whereas their absolute configurations were validated either through single-crystal x-ray diffraction analysis or via time-dependent density functional theory (TDDFT)-electronic circular dichroism (ECD) calculations. It is noted that the absolute configuration of compound 2 was determined for the first time. Meanwhile, all the isolated compounds were evaluated for their antibacterial activities. Among them, diameliresorcin (1) exhibited weak anti-Vibrio vulnificus activity with minimum inhibitory concentration (MIC) value of 46 µg/mL. |
| title | Diverse Secondary Metabolites From the Ligia exotica-Derived Fungus Diaporthe melitensis HZ-1. |
| topic | Microbial Sensitivity Tests Anti-Bacterial Agents Ascomycota Molecular Structure Molecular Conformation Crystallography, X-Ray Density Functional Theory Biological Products Dose-Response Relationship, Drug |
| url | https://pubmed.ncbi.nlm.nih.gov/40300654/ |