Exploring Anticonvulsant Effects of Pomalidomide by Targeting Oxidative Stress and Nrf2-Ho1 Signaling Pathway in Male Wistar Rats: A New Insight in Seizure Control.
Fuente:
PubMed
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266209157316609 |
|---|---|
| author | Khorasanian, Elnaz Rajabi-Maham, Hassan Azizi, Vahid Hosseini, Abdolkarim |
| author_facet | Khorasanian, Elnaz Rajabi-Maham, Hassan Azizi, Vahid Hosseini, Abdolkarim Khorasanian, Elnaz Rajabi-Maham, Hassan Azizi, Vahid Hosseini, Abdolkarim |
| collection | PubMed - marine biology |
| contents | Exploring Anticonvulsant Effects of Pomalidomide by Targeting Oxidative Stress and Nrf2-Ho1 Signaling Pathway in Male Wistar Rats: A New Insight in Seizure Control. Khorasanian, Elnaz Rajabi-Maham, Hassan Azizi, Vahid Hosseini, Abdolkarim Animals Male NF-E2-Related Factor 2 Oxidative Stress Rats Signal Transduction Seizures Thalidomide Anticonvulsants Rats, Wistar Pentylenetetrazole Heme Oxygenase (Decyclizing) Current medications for seizure symptoms can reduce seizure severity but do not stop or slow their progression. These drugs often have unpleasant side effects and may not work for all patients. The search for new therapeutic targets for seizure progression can be expedited through drug repurposing, which leverages existing approved medications, ultimately reducing clinical trial costs. This study investigates the neuroprotective properties of pomalidomide, an immunomodulatory drug, in a male rat model of pentylenetetrazol-induced seizures. Pomalidomide pretreatment significantly decreased the frequency and severity of seizures and delayed their onset. It elevated glutathione peroxidase (GPX) and superoxide dismutase (SOD) levels while lowering malondialdehyde (MDA), showcasing its antioxidant effects. Furthermore, it activated the Nrf2/HO-1 signaling pathway by increasing gene expression in the hippocampus, providing neuroprotection in the CA1 and CA3 regions. These findings suggest that pomalidomide may enhance the antioxidant defense system, support the Nrf2/HO-1 pathway, and protect the hippocampus, indicating its potential for treating patients with seizures, particularly intractable ones. |
| format | Artículo científico |
| id | pubmed_40310605 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology |
| record_format | pubmed |
| spellingShingle | Exploring Anticonvulsant Effects of Pomalidomide by Targeting Oxidative Stress and Nrf2-Ho1 Signaling Pathway in Male Wistar Rats: A New Insight in Seizure Control. Khorasanian, Elnaz Rajabi-Maham, Hassan Azizi, Vahid Hosseini, Abdolkarim Animals Male NF-E2-Related Factor 2 Oxidative Stress Rats Signal Transduction Seizures Thalidomide Anticonvulsants Rats, Wistar Pentylenetetrazole Heme Oxygenase (Decyclizing) Exploring Anticonvulsant Effects of Pomalidomide by Targeting Oxidative Stress and Nrf2-Ho1 Signaling Pathway in Male Wistar Rats: A New Insight in Seizure Control. Khorasanian, Elnaz Rajabi-Maham, Hassan Azizi, Vahid Hosseini, Abdolkarim Animals Male NF-E2-Related Factor 2 Oxidative Stress Rats Signal Transduction Seizures Thalidomide Anticonvulsants Rats, Wistar Pentylenetetrazole Heme Oxygenase (Decyclizing) Current medications for seizure symptoms can reduce seizure severity but do not stop or slow their progression. These drugs often have unpleasant side effects and may not work for all patients. The search for new therapeutic targets for seizure progression can be expedited through drug repurposing, which leverages existing approved medications, ultimately reducing clinical trial costs. This study investigates the neuroprotective properties of pomalidomide, an immunomodulatory drug, in a male rat model of pentylenetetrazol-induced seizures. Pomalidomide pretreatment significantly decreased the frequency and severity of seizures and delayed their onset. It elevated glutathione peroxidase (GPX) and superoxide dismutase (SOD) levels while lowering malondialdehyde (MDA), showcasing its antioxidant effects. Furthermore, it activated the Nrf2/HO-1 signaling pathway by increasing gene expression in the hippocampus, providing neuroprotection in the CA1 and CA3 regions. These findings suggest that pomalidomide may enhance the antioxidant defense system, support the Nrf2/HO-1 pathway, and protect the hippocampus, indicating its potential for treating patients with seizures, particularly intractable ones. |
| title | Exploring Anticonvulsant Effects of Pomalidomide by Targeting Oxidative Stress and Nrf2-Ho1 Signaling Pathway in Male Wistar Rats: A New Insight in Seizure Control. |
| topic | Animals Male NF-E2-Related Factor 2 Oxidative Stress Rats Signal Transduction Seizures Thalidomide Anticonvulsants Rats, Wistar Pentylenetetrazole Heme Oxygenase (Decyclizing) |
| url | https://pubmed.ncbi.nlm.nih.gov/40310605/ |